Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis
Evidence regarding the effectiveness of rehabilitation treatments in patients with bone metastases remains limited. This study evaluated the implementation and effectiveness of rehabilitation in patients with bone metastases who did not undergo surgery. This retrospective study included 200 patients...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Journal of Bone Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212137425000442 |
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| author | Ryo Yoshikawa Yasumitsu Fujii Ryoga Kashima Wataru Saho Risa Harada Daisuke Makiura Katsuya Fujiwara Junichiro Inoue Yoshiki Takeoka Ryoko Sawada Naomasa Fukase Keisuke Oe Hitomi Hara Kenichiro Kakutani Toshihiro Akisue Yoshitada Sakai |
| author_facet | Ryo Yoshikawa Yasumitsu Fujii Ryoga Kashima Wataru Saho Risa Harada Daisuke Makiura Katsuya Fujiwara Junichiro Inoue Yoshiki Takeoka Ryoko Sawada Naomasa Fukase Keisuke Oe Hitomi Hara Kenichiro Kakutani Toshihiro Akisue Yoshitada Sakai |
| author_sort | Ryo Yoshikawa |
| collection | DOAJ |
| description | Evidence regarding the effectiveness of rehabilitation treatments in patients with bone metastases remains limited. This study evaluated the implementation and effectiveness of rehabilitation in patients with bone metastases who did not undergo surgery. This retrospective study included 200 patients with nonsurgically treated bone metastases at our institution. The patients were categorized into a rehabilitation group (R group, n = 61) and a non-rehabilitation group (N group, n = 139). Over the course of one month, we compared activities of daily living (ADL), assessed using the Barthel Index (BI), quality of life (QOL), measured using the EuroQoL-5 Dimension (EQ-5D), and demographic and clinical characteristics. Propensity score matching was conducted to minimize selection bias. After matching, 31 patients in each group were included in the analysis. No statistically significant differences were observed in baseline BI and EQ-5D scores between the two groups. In the R group, BI improved significantly from 80 (interquartile range [IQR]: 60–100) to 90 (IQR: 70–100), and EQ-5D improved from 0.444 (IQR: 0.282–0.608) to 0.608 (IQR: 0.533–0.768). In contrast, no improvements were observed in either score in the N group. Chemotherapy was identified as a significant factor associated with improvements in BI (odds ratio 4.03) and EQ-5D (odds ratio 5.29). Rehabilitation may be a valuable treatment option for nonsurgically treated patients with bone metastases, warranting further validation in prospective studies. |
| format | Article |
| id | doaj-art-b6f3e2014ec74c9cae22c176048fcea3 |
| institution | Matheson Library |
| issn | 2212-1374 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj-art-b6f3e2014ec74c9cae22c176048fcea32025-08-01T04:44:35ZengElsevierJournal of Bone Oncology2212-13742025-08-0153100703Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysisRyo Yoshikawa0Yasumitsu Fujii1Ryoga Kashima2Wataru Saho3Risa Harada4Daisuke Makiura5Katsuya Fujiwara6Junichiro Inoue7Yoshiki Takeoka8Ryoko Sawada9Naomasa Fukase10Keisuke Oe11Hitomi Hara12Kenichiro Kakutani13Toshihiro Akisue14Yoshitada Sakai15Kobe University Graduate School of Medicine, Division of Rehabilitation Medicine, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Division of Rehabilitation Medicine, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Division of Rehabilitation Medicine, Kobe, Hyogo, Japan; Kobe University Hospital, Department of Physical Medicine and Rehabilitation, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Division of Rehabilitation Medicine, Kobe, Hyogo, Japan; Kobe University Hospital, Department of Physical Medicine and Rehabilitation, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Division of Rehabilitation Medicine, Kobe, Hyogo, Japan; Kobe University Hospital, Department of Physical Medicine and Rehabilitation, Kobe, Hyogo, JapanKobe University Hospital, Department of Rehabilitation Medicine, Kobe, Hyogo, JapanKobe University Graduate School of Health Sciences, Department of Rehabilitation Science, Kobe, Hyogo, JapanKobe University Hospital, Department of Rehabilitation Medicine, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Department of Orthopaedic Surgery, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Department of Orthopaedic Surgery, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Department of Orthopaedic Surgery, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Department of Orthopaedic Surgery, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Department of Orthopaedic Surgery, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Department of Orthopaedic Surgery, Kobe, Hyogo, JapanKobe University Graduate School of Health Sciences, Department of Rehabilitation Science, Kobe, Hyogo, JapanKobe University Graduate School of Medicine, Division of Rehabilitation Medicine, Kobe, Hyogo, Japan; Kobe University Hospital, Department of Physical Medicine and Rehabilitation, Kobe, Hyogo, Japan; Corresponding author.Evidence regarding the effectiveness of rehabilitation treatments in patients with bone metastases remains limited. This study evaluated the implementation and effectiveness of rehabilitation in patients with bone metastases who did not undergo surgery. This retrospective study included 200 patients with nonsurgically treated bone metastases at our institution. The patients were categorized into a rehabilitation group (R group, n = 61) and a non-rehabilitation group (N group, n = 139). Over the course of one month, we compared activities of daily living (ADL), assessed using the Barthel Index (BI), quality of life (QOL), measured using the EuroQoL-5 Dimension (EQ-5D), and demographic and clinical characteristics. Propensity score matching was conducted to minimize selection bias. After matching, 31 patients in each group were included in the analysis. No statistically significant differences were observed in baseline BI and EQ-5D scores between the two groups. In the R group, BI improved significantly from 80 (interquartile range [IQR]: 60–100) to 90 (IQR: 70–100), and EQ-5D improved from 0.444 (IQR: 0.282–0.608) to 0.608 (IQR: 0.533–0.768). In contrast, no improvements were observed in either score in the N group. Chemotherapy was identified as a significant factor associated with improvements in BI (odds ratio 4.03) and EQ-5D (odds ratio 5.29). Rehabilitation may be a valuable treatment option for nonsurgically treated patients with bone metastases, warranting further validation in prospective studies.http://www.sciencedirect.com/science/article/pii/S2212137425000442Bone metastasisRehabilitationActivities of daily livingQuality of lifePropensity score matching |
| spellingShingle | Ryo Yoshikawa Yasumitsu Fujii Ryoga Kashima Wataru Saho Risa Harada Daisuke Makiura Katsuya Fujiwara Junichiro Inoue Yoshiki Takeoka Ryoko Sawada Naomasa Fukase Keisuke Oe Hitomi Hara Kenichiro Kakutani Toshihiro Akisue Yoshitada Sakai Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis Journal of Bone Oncology Bone metastasis Rehabilitation Activities of daily living Quality of life Propensity score matching |
| title | Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis |
| title_full | Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis |
| title_fullStr | Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis |
| title_full_unstemmed | Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis |
| title_short | Effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention: A propensity score matching analysis |
| title_sort | effectiveness of rehabilitation treatment for bone metastasis patients without surgical intervention a propensity score matching analysis |
| topic | Bone metastasis Rehabilitation Activities of daily living Quality of life Propensity score matching |
| url | http://www.sciencedirect.com/science/article/pii/S2212137425000442 |
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