Isolated idiopathic hypoparathyroidism that developed in adulthood: a case report
Hypoparathyroidism is a rare endocrine disease. In most cases in adult patients, the cause of hypoparathyroidism is damage or removal of parathyroid glands during surgical interventions on the neck; other causes are rarely observed.Case report. A 52-year-old man with episodes of seizures, intense mu...
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Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
2021-12-01
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| Series: | Сеченовский вестник |
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| Online Access: | https://www.sechenovmedj.com/jour/article/view/369 |
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| author | G. E. Runova A. V. Oderiy I. V. Glinkina Yu. P. Sych S. E. Moshenina V. V. Fadeev |
| author_facet | G. E. Runova A. V. Oderiy I. V. Glinkina Yu. P. Sych S. E. Moshenina V. V. Fadeev |
| author_sort | G. E. Runova |
| collection | DOAJ |
| description | Hypoparathyroidism is a rare endocrine disease. In most cases in adult patients, the cause of hypoparathyroidism is damage or removal of parathyroid glands during surgical interventions on the neck; other causes are rarely observed.Case report. A 52-year-old man with episodes of seizures, intense muscle pain, progressing for 7 years and resistance to treatment with myorelaxant, anxiolytics and nonsteroidal anti-inflammatory drugs was examined and hypocalcemia associated with low parathyroid hormone and excessive urinary calcium excretion was found. Ultrasound examination didn't reveal any changes in parathyroid glands. The patient was diagnosed with idiopathic hypoparathyroidism. Treatment with calcium supplements and active metabolites of vitamin D led to an improvement in clinical symptoms and laboratory parameters.Discussion. Hypoparathyroidism as part of several genetic syndromes was excluded due to the late- onset of the disease and the absence of concomitant diseases. Ultrasound of the parathyroid glands made it possible to rule out metastasis and storage diseases. It is recommended to perform genetic testing of the chromosomes 22 and 10 to exclude rare variants of syndromic hypoparathyroidism with the late-onset in the form of isolated hypocalcemia. |
| format | Article |
| id | doaj-art-b6a002011eff4b8d94f8c5b3f08643ed |
| institution | Matheson Library |
| issn | 2218-7332 2658-3348 |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) |
| record_format | Article |
| series | Сеченовский вестник |
| spelling | doaj-art-b6a002011eff4b8d94f8c5b3f08643ed2025-08-03T13:30:20ZrusFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Сеченовский вестник2218-73322658-33482021-12-01123687510.47093/2218-7332.2021.187.05190Isolated idiopathic hypoparathyroidism that developed in adulthood: a case reportG. E. Runova0A. V. Oderiy1I. V. Glinkina2Yu. P. Sych3S. E. Moshenina4V. V. Fadeev5Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Hypoparathyroidism is a rare endocrine disease. In most cases in adult patients, the cause of hypoparathyroidism is damage or removal of parathyroid glands during surgical interventions on the neck; other causes are rarely observed.Case report. A 52-year-old man with episodes of seizures, intense muscle pain, progressing for 7 years and resistance to treatment with myorelaxant, anxiolytics and nonsteroidal anti-inflammatory drugs was examined and hypocalcemia associated with low parathyroid hormone and excessive urinary calcium excretion was found. Ultrasound examination didn't reveal any changes in parathyroid glands. The patient was diagnosed with idiopathic hypoparathyroidism. Treatment with calcium supplements and active metabolites of vitamin D led to an improvement in clinical symptoms and laboratory parameters.Discussion. Hypoparathyroidism as part of several genetic syndromes was excluded due to the late- onset of the disease and the absence of concomitant diseases. Ultrasound of the parathyroid glands made it possible to rule out metastasis and storage diseases. It is recommended to perform genetic testing of the chromosomes 22 and 10 to exclude rare variants of syndromic hypoparathyroidism with the late-onset in the form of isolated hypocalcemia.https://www.sechenovmedj.com/jour/article/view/369isolated hypoparathyroidismisolated hypocalcemialate-onset of hypoparathyroidismconvulsive syndromecalcification of the basal gangliafahr's syndromeseizures in an adult patient |
| spellingShingle | G. E. Runova A. V. Oderiy I. V. Glinkina Yu. P. Sych S. E. Moshenina V. V. Fadeev Isolated idiopathic hypoparathyroidism that developed in adulthood: a case report Сеченовский вестник isolated hypoparathyroidism isolated hypocalcemia late-onset of hypoparathyroidism convulsive syndrome calcification of the basal ganglia fahr's syndrome seizures in an adult patient |
| title | Isolated idiopathic hypoparathyroidism that developed in adulthood: a case report |
| title_full | Isolated idiopathic hypoparathyroidism that developed in adulthood: a case report |
| title_fullStr | Isolated idiopathic hypoparathyroidism that developed in adulthood: a case report |
| title_full_unstemmed | Isolated idiopathic hypoparathyroidism that developed in adulthood: a case report |
| title_short | Isolated idiopathic hypoparathyroidism that developed in adulthood: a case report |
| title_sort | isolated idiopathic hypoparathyroidism that developed in adulthood a case report |
| topic | isolated hypoparathyroidism isolated hypocalcemia late-onset of hypoparathyroidism convulsive syndrome calcification of the basal ganglia fahr's syndrome seizures in an adult patient |
| url | https://www.sechenovmedj.com/jour/article/view/369 |
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