Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit
PurposeTo investigate the distribution characteristics and drug resistance of pathogenic bacteria in bloodstream infections, providing a basis for rational clinical treatment.Patients and methodsRetrospective analysis of 1,282 pathogenic strains isolated from blood cultures in the intensive care uni...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1464573/full |
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| author | Zeshi Liu Hehui Cai Jing Lei Xue Zhang Jian Yin Yanping Zhang Xueping Yu Xueping Yu Yan Geng |
| author_facet | Zeshi Liu Hehui Cai Jing Lei Xue Zhang Jian Yin Yanping Zhang Xueping Yu Xueping Yu Yan Geng |
| author_sort | Zeshi Liu |
| collection | DOAJ |
| description | PurposeTo investigate the distribution characteristics and drug resistance of pathogenic bacteria in bloodstream infections, providing a basis for rational clinical treatment.Patients and methodsRetrospective analysis of 1,282 pathogenic strains isolated from blood cultures in the intensive care unit (ICU) of the Second Affiliated Hospital of Xi’an Jiaotong University from January 1, 2019, to December 31, 2022.ResultsGram-positive bacteria (52.0%) slightly predominated over gram-negative bacteria (48.0%). The top three gram-positive bacteria were Coagulase-negative Staphylococcus (28.0%), Enterococcus faecium (7.4%), and Staphylococcus aureus (6.6%). Staphylococci exhibited a high resistance rate to penicillin, oxacillin, and erythromycin; no strains resistant to vancomycin or linezolid were found. Among the Enterococci, Enterococcus faecium had a high resistance rate to penicillin, ampicillin, and erythromycin. Two strains of Enterococcus faecalis were resistant to linezolid, but none to vancomycin. The top three gram-negative bacteria were Escherichia coli (14.7%), Klebsiella pneumoniae (14.0%), and Acinetobacter baumannii (4.8%). The resistance rate of Escherichia coli to carbapenems increased from 0.0 to 2.3%. Acinetobacter baumannii reached 100% carbapenem resistance (up from 75.0%), while Klebsiella pneumoniae demonstrated 21.1-80.4% resistance to various carbapenems.ConclusionThe isolation rate of gram-positive bacteria in patients with bloodstream infection in the ICU of the Second Affiliated Hospital of Xi’an Jiaotong University was slightly higher than that of gram-negative bacteria. The alarming carbapenem resistance among gram-negative pathogens and emerging linezolid resistance in Enterococci demand urgent clinical interventions, including enhanced surveillance, antimicrobial stewardship, and novel therapeutic strategies. |
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| institution | Matheson Library |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj-art-b66f2979e7e6427db1a711b1b716a09f2025-07-14T05:25:39ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-07-011610.3389/fmicb.2025.14645731464573Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unitZeshi Liu0Hehui Cai1Jing Lei2Xue Zhang3Jian Yin4Yanping Zhang5Xueping Yu6Xueping Yu7Yan Geng8Department of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Clinical Laboratory, Fujian Medical University Affiliated First Quanzhou hospital, Quanzhou, Fujian, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Infection Disease, Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian province, Fujian Medical University Affiliated First Quanzhou Hospital, Quanzhou, Fujian, ChinaKey Laboratory of Screening and Control of Infectious Diseases (Quanzhou Medical College), Fujian Provincial University, Quanzhou, Fujian, ChinaDepartment of Clinical Laboratory, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaPurposeTo investigate the distribution characteristics and drug resistance of pathogenic bacteria in bloodstream infections, providing a basis for rational clinical treatment.Patients and methodsRetrospective analysis of 1,282 pathogenic strains isolated from blood cultures in the intensive care unit (ICU) of the Second Affiliated Hospital of Xi’an Jiaotong University from January 1, 2019, to December 31, 2022.ResultsGram-positive bacteria (52.0%) slightly predominated over gram-negative bacteria (48.0%). The top three gram-positive bacteria were Coagulase-negative Staphylococcus (28.0%), Enterococcus faecium (7.4%), and Staphylococcus aureus (6.6%). Staphylococci exhibited a high resistance rate to penicillin, oxacillin, and erythromycin; no strains resistant to vancomycin or linezolid were found. Among the Enterococci, Enterococcus faecium had a high resistance rate to penicillin, ampicillin, and erythromycin. Two strains of Enterococcus faecalis were resistant to linezolid, but none to vancomycin. The top three gram-negative bacteria were Escherichia coli (14.7%), Klebsiella pneumoniae (14.0%), and Acinetobacter baumannii (4.8%). The resistance rate of Escherichia coli to carbapenems increased from 0.0 to 2.3%. Acinetobacter baumannii reached 100% carbapenem resistance (up from 75.0%), while Klebsiella pneumoniae demonstrated 21.1-80.4% resistance to various carbapenems.ConclusionThe isolation rate of gram-positive bacteria in patients with bloodstream infection in the ICU of the Second Affiliated Hospital of Xi’an Jiaotong University was slightly higher than that of gram-negative bacteria. The alarming carbapenem resistance among gram-negative pathogens and emerging linezolid resistance in Enterococci demand urgent clinical interventions, including enhanced surveillance, antimicrobial stewardship, and novel therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1464573/fullblood culturedrug resistancepathogensintensive care unitantimicrobial susceptibility test |
| spellingShingle | Zeshi Liu Hehui Cai Jing Lei Xue Zhang Jian Yin Yanping Zhang Xueping Yu Xueping Yu Yan Geng Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit Frontiers in Microbiology blood culture drug resistance pathogens intensive care unit antimicrobial susceptibility test |
| title | Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit |
| title_full | Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit |
| title_fullStr | Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit |
| title_full_unstemmed | Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit |
| title_short | Distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit |
| title_sort | distribution and analysis of the resistance profiles of bacteria isolated from blood cultures in the intensive care unit |
| topic | blood culture drug resistance pathogens intensive care unit antimicrobial susceptibility test |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1464573/full |
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