Probiotic peptidoglycan skeleton enhances vaccine efficacy against MRSA by inducing trained immunity via the TLR2/JAK-STAT3 pathway

Probiotic peptidoglycan skeleton enhances vaccine efficacy against MRSA by inducing trained immunity via the TLR2/JAK-STAT3 pathway

Trained immunity refers to the ability of trained innate immune cells to generate an immune memory that produces rapid, broad-spectrum, and long-lasting protection against heterologous stimuli. Based on the rapid and broad-spectrum protection that the peptidoglycan backbone from lactic acid bacteria...

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Bibliographic Details
Main Authors: Lingdi Niu, Haoyuan Duan, Jiaqing Wang, Zheng Jia, Hai Li, Junjie Guo, Shuhe Zhang, Ning Liu, Yaxin Miao, Junwei Ge, Fang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
peptidoglycan backbone
bacterium-like particles
innate immunity
trained immunity
MRSA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1606626/full
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