Timp2-modified gelatinhydroxyphenylpropionic acid hydrogels reverse enhanced scleral recovery and suppress myopia development in mice

Timp2-modified gelatinhydroxyphenylpropionic acid hydrogels reverse enhanced scleral recovery and suppress myopia development in mice

A novel therapeutic strategy for form deprivation myopia (FDM) involving Timp2-modified scleral stem cells (SSCTimp2) embedded in gelatin-hydroxyphenylpropionic acid (Gtn-HPA) hydrogel was investigated. Transcriptome and single-cell RNA sequencing analyses identified Timp2 as a crucial factor in FDM...

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Bibliographic Details
Main Authors: Kaiqi Liu, Ting Li, Lingwen Gu, Zhenyu Jiang, Jing Jiang, Xi Yang, Yang Zhou, Xiao Feng, Qianqian Gong, Lihua Zhao, Yiming Chen, Chao Yang, Tao Jiang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Form deprivation myopia
Timp2
Scleral stem cells
Hydrogel
Scleral recovery
Myopia treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425005125
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