Development of Methods for the Synthesis of Malathion-D<sub>6</sub>, Chlorophos-D<sub>6</sub>, and Dichlorophos-D<sub>6</sub> for Use as Internal Standards in the Analysis of Medicinal Plant Raw Materials and Herbal Medicinal Products

Development of Methods for the Synthesis of Malathion-D<sub>6</sub>, Chlorophos-D<sub>6</sub>, and Dichlorophos-D<sub>6</sub> for Use as Internal Standards in the Analysis of Medicinal Plant Raw Materials and Herbal Medicinal Products

Scientific relevance. Deuterated analogues of test substances, when used as internal standards, enable analysts to determine traces of residual pesticides in a medicinal plant raw material by gas or liquid chromatography coupled with mass spectrometry. This prompts the search for an undemanding meth...

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Bibliographic Details
Main Authors: V. I. Krylov, V. A. Yashkir, A. V. Braun, I. I. Krylov, O. V. Fateenkova, A. M. Savvateev
Format: Article
Language:Russian
Published: Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) 2023-09-01
Series:Регуляторные исследования и экспертиза лекарственных средств
Subjects:
organophosphate pesticides
medicinal plant raw materials
standardisation
nmr
high-resolution mass spectrometry
reference standards
deuterium label
Online Access:https://www.vedomostincesmp.ru/jour/article/view/517
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