Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancer
Objective To evaluate the efficacy and safety of the combination of immunotherapy and targeted therapy and chemotherapy in third-line treatment of patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC). Methods A retrospective cohort trial was conducted on patients with MS...
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Editorial Office of Journal of Army Medical University
2025-07-01
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| Series: | 陆军军医大学学报 |
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| Online Access: | https://aammt.tmmu.edu.cn/html/202504016.html |
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| author | ZHAO Wensi SONG Jian |
| author_facet | ZHAO Wensi SONG Jian |
| author_sort | ZHAO Wensi |
| collection | DOAJ |
| description | Objective To evaluate the efficacy and safety of the combination of immunotherapy and targeted therapy and chemotherapy in third-line treatment of patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC). Methods A retrospective cohort trial was conducted on patients with MSS mCRC treated with third-line immunotherapy combined with targeted therapy and chemotherapy in our hospital from January 2020 to December 2023. The clinical data were collected. Kaplan-Meier survival analysis was employed to analyze progression-free survival (PFS) and overall survival (OS). Objective response rate (ORR), disease control rate (DCR) and other indicators were statistically analyzed to evaluate the clinical efficacy. The incidence and severity of adverse events during the treatment process were recorded to assess the safety. Results A total of 80 patients were included in the analysis, 55 in the group of immunotherapy plus targeted therapy and 25 in the group of immunotherapy combined with targeted therapy and chemotherapy. The group of immunotherapy combined with targeted therapy and chemotherapy had significantly longer median PFS (6.3 vs 4.4 months; HR=0.58, 95%CI: 0.35~0.96; P=0.031) and OS (15.5 vs 10.1 months; HR=0.47, 95%CI: 0.27~0.81; P=0.006), and obviously higher ORR (32.0% vs 10.9%; OR=0.26, 95%CI: 0.07~0.79; P=0.021) and DCR (92.0% vs 78.2%; OR=0.31, 95%CI: 0.07~1.52; P=0.132) when compared to the group of immunotherapy plus targeted therapy. The incidence of adverse events at all grade and at grade 3 and above was 96.4% and 32.7% in the group of immunotherapy plus targeted therapy, and 100.0% and 36.0% in the group of immunotherapy combined with targeted therapy and chemotherapy, which mainly included bone marrow hematopoietic inhibition, hand-foot skin reaction, liver function impairment and thyroid function abnormality. Conclusion The triple therapy of immunotherapy plus targeted therapy and chemotherapy is a more effective and safer treatment than the double therapy of immunotherapy plus targeted therapy in treatment of MSS mCRC patients.
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| format | Article |
| id | doaj-art-b471f51aad494cc487d4494fe47c38f9 |
| institution | Matheson Library |
| issn | 2097-0927 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Editorial Office of Journal of Army Medical University |
| record_format | Article |
| series | 陆军军医大学学报 |
| spelling | doaj-art-b471f51aad494cc487d4494fe47c38f92025-07-14T06:09:35ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272025-07-0147131512152110.16016/j.2097-0927.202504016Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancerZHAO Wensi 0SONG Jian1Department of Oncology, Renmin Hospital of Wuhan University， Wuhan， Hubei， China Department of Pharmacy, Renmin Hospital of Wuhan University， Wuhan， Hubei， ChinaObjective To evaluate the efficacy and safety of the combination of immunotherapy and targeted therapy and chemotherapy in third-line treatment of patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC). Methods A retrospective cohort trial was conducted on patients with MSS mCRC treated with third-line immunotherapy combined with targeted therapy and chemotherapy in our hospital from January 2020 to December 2023. The clinical data were collected. Kaplan-Meier survival analysis was employed to analyze progression-free survival (PFS) and overall survival (OS). Objective response rate (ORR), disease control rate (DCR) and other indicators were statistically analyzed to evaluate the clinical efficacy. The incidence and severity of adverse events during the treatment process were recorded to assess the safety. Results A total of 80 patients were included in the analysis, 55 in the group of immunotherapy plus targeted therapy and 25 in the group of immunotherapy combined with targeted therapy and chemotherapy. The group of immunotherapy combined with targeted therapy and chemotherapy had significantly longer median PFS (6.3 vs 4.4 months; HR=0.58, 95%CI: 0.35~0.96; P=0.031) and OS (15.5 vs 10.1 months; HR=0.47, 95%CI: 0.27~0.81; P=0.006), and obviously higher ORR (32.0% vs 10.9%; OR=0.26, 95%CI: 0.07~0.79; P=0.021) and DCR (92.0% vs 78.2%; OR=0.31, 95%CI: 0.07~1.52; P=0.132) when compared to the group of immunotherapy plus targeted therapy. The incidence of adverse events at all grade and at grade 3 and above was 96.4% and 32.7% in the group of immunotherapy plus targeted therapy, and 100.0% and 36.0% in the group of immunotherapy combined with targeted therapy and chemotherapy, which mainly included bone marrow hematopoietic inhibition, hand-foot skin reaction, liver function impairment and thyroid function abnormality. Conclusion The triple therapy of immunotherapy plus targeted therapy and chemotherapy is a more effective and safer treatment than the double therapy of immunotherapy plus targeted therapy in treatment of MSS mCRC patients. https://aammt.tmmu.edu.cn/html/202504016.htmlcolorectal cancermicrosatellite stabilityimmunotherapytargeted therapychemotherapy |
| spellingShingle | ZHAO Wensi SONG Jian Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancer 陆军军医大学学报 colorectal cancer microsatellite stability immunotherapy targeted therapy chemotherapy |
| title | Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancer |
| title_full | Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancer |
| title_fullStr | Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancer |
| title_full_unstemmed | Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancer |
| title_short | Efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third-line treatment of microsatellite stable metastatic colorectal cancer |
| title_sort | efficacy and safety of immunotherapy combined with targeted therapy and chemotherapy in third line treatment of microsatellite stable metastatic colorectal cancer |
| topic | colorectal cancer microsatellite stability immunotherapy targeted therapy chemotherapy |
| url | https://aammt.tmmu.edu.cn/html/202504016.html |
| work_keys_str_mv | AT zhaowensi efficacyandsafetyofimmunotherapycombinedwithtargetedtherapyandchemotherapyinthirdlinetreatmentofmicrosatellitestablemetastaticcolorectalcancer AT songjian efficacyandsafetyofimmunotherapycombinedwithtargetedtherapyandchemotherapyinthirdlinetreatmentofmicrosatellitestablemetastaticcolorectalcancer |