Hydnocarpin, a Natural Flavonolignan, Induces the ROS-Mediated Apoptosis of Ovarian Cancer Cells and Reprograms Tumor-Associated Immune Cells

Hydnocarpin, a Natural Flavonolignan, Induces the ROS-Mediated Apoptosis of Ovarian Cancer Cells and Reprograms Tumor-Associated Immune Cells

Ovarian cancer, the most lethal form of gynecological cancer worldwide with a poor prognosis, is largely driven by an immunosuppressive tumor microenvironment. In this study, we investigated the anticancer effects of hydnocarpin, a natural flavonolignan derived from the flowers of <i>Pueraria...

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Bibliographic Details
Main Authors: Jae-Yoon Kim, Yejin Kim, Soo-Yeon Woo, Jin-Ok Kim, Hyunsoo Kim, So-Ri Son, Dae Sik Jang, Jung-Hye Choi
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Antioxidants
Subjects:
ovarian cancer
tumor microenvironment
<i>Pueraria Flos</i>
hydnocarpin
reactive oxidative stress
tumor-associated macrophages
Online Access:https://www.mdpi.com/2076-3921/14/7/846
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