Pharmacodynamics, pharmacokinetics, interactions with other drugs, toxicity and clinical effectiveness of proton pump inhibitors

QR Code

Pharmacodynamics, pharmacokinetics, interactions with other drugs, toxicity and clinical effectiveness of proton pump inhibitors

The document comprehensively reviews proton pump inhibitors (PPIs), focusing on their pharmacodynamics, pharmacokinetics, drug interactions, toxicity, and clinical efficacy. PPIs irreversibly inhibit the H+/K+-ATPase enzyme in gastric parietal cells, effectively reducing gastric acid secretion. Thes...

Full description

Saved in:

Bibliographic Details
Main Authors:	Łukasz Wołowiec, Joanna Osiak-Gwiazdowska, Albert Jaśniak, Michał Janiak, Lidia Wydeheft, Magdalena Łukasiak, Małgorzata Pellowska, Grzegorz Grześk
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Pharmacology
Subjects:	PPIs pharmacokinetics interactions pharmacology pharmacodynamics
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1507812/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Population Pharmacokinetics and Pharmacodynamics with Enterohepatic Recirculation of Co-Medication of Rosuvastatin and Ezetimibe
by: An H, et al.
Published: (2025-06-01)

COMPARISON OF PHARMACOKINETICS AND PHARMACODYNAMICS OF THE ORIGINAL AND GENERIC ENALAPRIL IN THE ELDERLY PATIENTS WITH ARTERIAL HYPERTENSION
by: O. P. Bobrova, et al.
Published: (2015-12-01)

Pharmacokinetics/pharmacodynamics of antibiotics with different protein binding rates in hemodialysis
by: SHEN Yue, et al.
Published: (2025-06-01)

Long-acting relaxin analogues: a novel tool in cardiology
by: Łukasz Wołowiec, et al.
Published: (2025-08-01)

Association of Genetic Variants With Rivaroxaban Pharmacokinetics and Pharmacodynamics and Hemorrhage Risk Factors in Patients With Venous Thromboembolism
by: Hui Li, et al.
Published: (2025-06-01)

Hypocalcemia After Thyroidectomy in Patients Taking Proton Pump Inhibitors
by: Maxwell Rossip, et al.
Published: (2025-06-01)

A Comparison of in-vitro Pharmacokinetics and Pharmacodynamics of Branded and Its Locally Produced Cefuroxime Sodium Against Staphylococcus and Escherichia Escherichia coli
by: Du M, et al.
Published: (2025-06-01)

Assessment of pharmacokinetics-pharmacodynamics relationship of tropoxine in rats
by: V. P. Zherdev, et al.
Published: (2016-09-01)

Pharmacokinetic relationships in psychotropic drugs effects
by: G. B. Kolyvanov, et al.
Published: (2021-06-01)

Pharmacokinetics, Pharmacodynamic, Safety and Tolerability of Fazamorexant, a Novel Dual Orexin Receptor Antagonist: Report of the First-in-Human Study
by: Ni J, et al.
Published: (2025-06-01)

Pharmacokinetic and pharmacodynamic integration and resistance analysis of cefquinome against Streptococcus uberis in vitro dynamic model
by: Chongyang Li, et al.
Published: (2025-07-01)

EXPERT EVALUATION OF PRECLINICAL STUDIES OF PRIMARY AND SECONDARY PHARMACODYNAMICS OF MEDICINES
by: G. N. Engalycheva, et al.
Published: (2018-12-01)

Are plasma drug concentrations still necessary? Rethinking the pharmacokinetic link in dose–response relationships
by: Nicolas Simon, et al.
Published: (2025-07-01)

Proton pump inhibitors in pediatric practice
by: Anna A. Shilova, et al.
Published: (2023-11-01)

Pharmacokinetic analysis of meropenem therapeutic drug monitoring data (TDM) in critically ill adult patients
by: I. B. Bondareva, et al.
Published: (2022-03-01)

Pharmacological incompatibility
by: A. I. Vengerovsky
Published: (2003-09-01)

Modeling the Influence of <i>CYP2C9</i> and <i>ABCB1</i> Gene Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Losartan
by: Dmitry Babaev, et al.
Published: (2025-07-01)

Review of the textbook “Clinical and pharmacological characteristics of biotechnological drugs: from classifications to adverse events”
by: V. I. Petrov
Published: (2024-04-01)

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity Profiles of a Single‐Dose JYB1904 in Healthy Chinese Participants: A Phase Ia, Randomized, Double‐Blind, Placebo‐Controlled Study
by: Zhen‐Wei Shen, et al.
Published: (2025-06-01)

Compliance of extended infusion of piperacillin/tazobactam with the desired pharmacokinetic/pharmacodynamic index in septic patients
by: Tomić Nataša, et al.
Published: (2025-01-01)

Preclinical Study of Pharmacokinetic/Pharmacodynamic Analysis of Tebipenem Using Monte Carlo Simulation for Extended-Spectrum β-Lactamase-Producing Bacterial Urinary Tract Infections in Japanese Patients According to Renal Function
by: Fumiya Ebihara, et al.
Published: (2025-06-01)

Examine the pharmacokinetics of three formulations of the drug for regenerative gene therapy damage the surface of human tissues of various etiologies
by: I. V. Duhovlinov, et al.
Published: (2013-04-01)

Results of a double-blind, randomized, comparative, cross-sectional study of the pharmacokinetics and pharmacodynamics of genetically engineered human insulin preparations
by: Alexander Mayorov, et al.
Published: (2019-09-01)

CLINICAL AND PHARMACOLOGICAL APPROACHES TO OPTIMIZE THE DOSING REGIMEN OF ANTIBACTERIAL DRUGS IN PEDIATRICS
by: Natal’ya B. Lazareva, et al.
Published: (2018-04-01)

The Changing Landscape of Antibiotic Treatment: Reevaluating Treatment Length in the Age of New Agents
by: Francesca Serapide, et al.
Published: (2025-07-01)

The changes of pharmacokinetic behavior of the medical substances as a consequence of the „in vivo” interaction with general anesthetics
by: Năstasă V.,, et al.
Published: (2007-07-01)

Basic principles of combination therapy: focus on drug-drug interaction
by: S. Yu. Martsevich, et al.
Published: (2021-11-01)

Pharmacotherapy variability and precision medicine in neurocritical care
by: Sherif Hanafy Mahmoud, et al.
Published: (2025-07-01)

Antechodynamics and Antechokinetics: Dynamics and Kinetics of Antibiotic Resistance Biomolecules
by: F. Baquero, et al.
Published: (2025-06-01)

Impact of Renal Impairment on the Pharmacodynamic and Pharmacokinetic Profiles of Epaminurad, a Novel Uric Acid Transporter 1 Inhibitor
by: Seo Yeong Park, et al.
Published: (2025-06-01)

Biological and Biosimilar Medicines in Contemporary Pharmacotherapy for Metabolic Syndrome
by: Wiktoria Górecka, et al.
Published: (2025-06-01)

Optimizing Organ Donation After Euthanasia: A Critical Appraisal
by: E. A. J. Alkemade, et al.
Published: (2025-04-01)

Rationale for contemporary antimicrobial treatment of Stenotrophomonas maltophilia: a narrative review
by: John Turnidge, et al.
Published: (2025-06-01)

Investigation of the <i>ABCB1</i> Gene Polymorphism and Food Effects on the Avatrombopag Pharmacokinetics in Chinese Individuals: A Population Pharmacokinetic/Pharmacodynamic Analysis
by: Xin Liu, et al.
Published: (2025-06-01)

Results of the Estimation of Biosimilarity of RinLiz<sup>®</sup> (LLC «GEROPHARM», Russia) and Humalog<sup>®</sup> (Lilly France, France) Using the Method of the Hyperinsulinemic Eulygemic Clamp on Healthy Voluntary
by: A. Yu. Mayorov, et al.
Published: (2020-05-01)

Pharmacogenetics of carbamazepine
by: N. A. Shnayder, et al.
Published: (2020-01-01)

Drug disposition in humans : the basis of clinical pharmacology /
by: Creasey, William A.
Published: (1979)

Fermentative Production of 1,3;1,6-β-D-Glucan (Translam), a Labeled Immunostimulant and Investigation of Its Pharmacokinetics and Pharmacodynamics
by: T. N. Zvyagintseva, et al.
Published: (2020-05-01)

Quality Standards of Preclinical Pharmacological Studies
by: G. N. Engalycheva, et al.
Published: (2019-12-01)

The influence of the pharmacokinetics and bioavailability of cyclo-L-propylglycine to the manifestation of its main pharmacological effects in experimental animals
by: S. S. Boyko, et al.
Published: (2021-06-01)