CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION
Abstract. We had investigated serum levels of IL-6, IL-8, IL-10, IL-1ra and TNFα in peripheral blood of pregnant women at the terms of 38 to 40 weeks with polyhydramnios and serum IgG antibodies specific for Chlamydia trachomatis (titers of 1:20 to 1:40). Same parameters were tested in umbilical cor...
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/602 |
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| author | I. A. Botvin’eva L. V. Renge V. N. Zorina R. M. Zorina A. N. Polukarov L. G. Bazhenova |
| author_facet | I. A. Botvin’eva L. V. Renge V. N. Zorina R. M. Zorina A. N. Polukarov L. G. Bazhenova |
| author_sort | I. A. Botvin’eva |
| collection | DOAJ |
| description | Abstract. We had investigated serum levels of IL-6, IL-8, IL-10, IL-1ra and TNFα in peripheral blood of pregnant women at the terms of 38 to 40 weeks with polyhydramnios and serum IgG antibodies specific for Chlamydia trachomatis (titers of 1:20 to 1:40). Same parameters were tested in umbilical cord blood sera, obtained at delivery. We had found high levels of TNFα, IL-6, IL-8, IL-10 in sera from umbilical cord blood, and increased levels of TNFα in maternal sera before delivery in a group of women with high Apgar scores of their children (≥ 8 points), in comparison with control group. High levels of TNFα, IL-6, IL-10 in sera from umbical cord and increased serum concentrations of IL-6, IL-10, IL-1ra and TNFα before delivery were evaluated in group of women with circulating antibodies against C. trachomatis during pregnancy and with low degrees of newborn children (< 7 by Apgar score). We suggest that high cytokine levels in maternal blood and in sera of umbilical cord blood from women with polyhydramnios and circulating antibodies against C. trachomatis sufficiently correlate with high clinical risk of intrauterine infection in newborns. However, high inter-individual variability of the cytokine parameters does not permit their usage as independent diagnostic criteria. |
| format | Article |
| id | doaj-art-b1d6e4d4d0ba4d3dbc13dfddea95a99f |
| institution | Matheson Library |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-b1d6e4d4d0ba4d3dbc13dfddea95a99f2025-08-04T14:30:32ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0115327728210.15789/1563-0625-2013-3-277-282599CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTIONI. A. Botvin’eva0L. V. Renge1V. N. Zorina2R. M. Zorina3A. N. Polukarov4L. G. Bazhenova5Zonal Perinatal Center, NovokusnetskZonal Perinatal Center, NovokusnetskNovokuznetsk State Institute for Postgraduate Education, NovokuznetskNovokuznetsk State Institute for Postgraduate Education, NovokuznetskZonal Perinatal Center, NovokusnetskNovokuznetsk State Institute for Postgraduate Education, NovokuznetskAbstract. We had investigated serum levels of IL-6, IL-8, IL-10, IL-1ra and TNFα in peripheral blood of pregnant women at the terms of 38 to 40 weeks with polyhydramnios and serum IgG antibodies specific for Chlamydia trachomatis (titers of 1:20 to 1:40). Same parameters were tested in umbilical cord blood sera, obtained at delivery. We had found high levels of TNFα, IL-6, IL-8, IL-10 in sera from umbilical cord blood, and increased levels of TNFα in maternal sera before delivery in a group of women with high Apgar scores of their children (≥ 8 points), in comparison with control group. High levels of TNFα, IL-6, IL-10 in sera from umbical cord and increased serum concentrations of IL-6, IL-10, IL-1ra and TNFα before delivery were evaluated in group of women with circulating antibodies against C. trachomatis during pregnancy and with low degrees of newborn children (< 7 by Apgar score). We suggest that high cytokine levels in maternal blood and in sera of umbilical cord blood from women with polyhydramnios and circulating antibodies against C. trachomatis sufficiently correlate with high clinical risk of intrauterine infection in newborns. However, high inter-individual variability of the cytokine parameters does not permit their usage as independent diagnostic criteria.https://www.mimmun.ru/mimmun/article/view/602chlamydia trachomatisigg antibodiespregnancypolyhydramnionintrauterine infectioncytokines |
| spellingShingle | I. A. Botvin’eva L. V. Renge V. N. Zorina R. M. Zorina A. N. Polukarov L. G. Bazhenova CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION Медицинская иммунология chlamydia trachomatis igg antibodies pregnancy polyhydramnion intrauterine infection cytokines |
| title | CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION |
| title_full | CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION |
| title_fullStr | CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION |
| title_full_unstemmed | CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION |
| title_short | CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION |
| title_sort | cytokine levels in maternal blood and umbical cord sera from women with symptoms of intrauterine infection |
| topic | chlamydia trachomatis igg antibodies pregnancy polyhydramnion intrauterine infection cytokines |
| url | https://www.mimmun.ru/mimmun/article/view/602 |
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