Analysis of original bis-arylazaazkanes derivatives compliance with the calculated pharmacophoric models of biaromatic ligands of cardioprotective drugs biotargets

Eight important biotargets of biaromatic cardioprotective drugs were selected in this work: calcium Cav1.2-channel, sodium Nav1.5-channel, potassium hERG-channel and Kv1.5-channel, HCN-channel, β1-adrenergic receptor, ryanodine RyR2-receptor and σ1-receptor. Biaromatic ligands databases were collect...

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Bibliographic Details
Main Authors: G. V. Mokrov, A. S. Pantileev, T. Yu. Vorobieva, V. E. Biryukova, S. A. Kryzhanovskii, V. L. Dorofeev
Format: Article
Language:Russian
Published: LLC “Publisher OKI” 2024-06-01
Series:Фармакокинетика и Фармакодинамика
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Online Access:https://www.pharmacokinetica.ru/jour/article/view/410
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