CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS
Correlation between purinenucleotides exchange and antioxidant system in patients with colorectal cancer (CC), as well as influence of key enzymes of purine decomposition on formation of active forms of oxygen were studied. During the process of study, enzymatic indicators of prooxidant system – ade...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/27 |
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| author | S. А. Zuikov B. G. Borzenko О. V. Zuikova |
| author_facet | S. А. Zuikov B. G. Borzenko О. V. Zuikova |
| author_sort | S. А. Zuikov |
| collection | DOAJ |
| description | Correlation between purinenucleotides exchange and antioxidant system in patients with colorectal cancer (CC), as well as influence of key enzymes of purine decomposition on formation of active forms of oxygen were studied. During the process of study, enzymatic indicators of prooxidant system – adenosine deaminase and xanthineoxidase, as well as the level of nitric oxide were identified. Superoxidedismutase and glutathione peroxidase were the indicator of antiradical system. 22 patients aged 40–59 years with colorectal cancer of different stage were examined. A significant increase in indicators of prooxidant system in tissue homogenate of patients with CC and ambiguous changes in the activity of the antioxidant system, depending on the stage of the disease, were established. It was established that during the oxidative stress and in conditions of hypoxia, at the later stages of cancer, antioxidants may contribute to better survival ability of tumor cells and to more rapid tumor progression. |
| format | Article |
| id | doaj-art-b0c7ce3c18a94e5a9bae509bc5fa5606 |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-b0c7ce3c18a94e5a9bae509bc5fa56062025-08-04T10:33:34ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-0102242727CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORSS. А. Zuikov0B. G. Borzenko1О. V. Zuikova2Donetsk National Medical University, DonetskDonetsk National Medical University, DonetskDonetsk National Medical University, DonetskCorrelation between purinenucleotides exchange and antioxidant system in patients with colorectal cancer (CC), as well as influence of key enzymes of purine decomposition on formation of active forms of oxygen were studied. During the process of study, enzymatic indicators of prooxidant system – adenosine deaminase and xanthineoxidase, as well as the level of nitric oxide were identified. Superoxidedismutase and glutathione peroxidase were the indicator of antiradical system. 22 patients aged 40–59 years with colorectal cancer of different stage were examined. A significant increase in indicators of prooxidant system in tissue homogenate of patients with CC and ambiguous changes in the activity of the antioxidant system, depending on the stage of the disease, were established. It was established that during the oxidative stress and in conditions of hypoxia, at the later stages of cancer, antioxidants may contribute to better survival ability of tumor cells and to more rapid tumor progression.https://www.siboncoj.ru/jour/article/view/27xanthine oxidaseadenosine deaminasenitric oxidesuperoxide dismutaseglutathione peroxidasehomogenatecolorectal cancer |
| spellingShingle | S. А. Zuikov B. G. Borzenko О. V. Zuikova CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS Сибирский онкологический журнал xanthine oxidase adenosine deaminase nitric oxide superoxide dismutase glutathione peroxidase homogenate colorectal cancer |
| title | CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS |
| title_full | CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS |
| title_fullStr | CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS |
| title_full_unstemmed | CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS |
| title_short | CORRELATION OF PRO-OXIDANT WITH ANTIOXIDANT SYSTEMS IN CASE OF COLORECTAL TUMORS |
| title_sort | correlation of pro oxidant with antioxidant systems in case of colorectal tumors |
| topic | xanthine oxidase adenosine deaminase nitric oxide superoxide dismutase glutathione peroxidase homogenate colorectal cancer |
| url | https://www.siboncoj.ru/jour/article/view/27 |
| work_keys_str_mv | AT sazuikov correlationofprooxidantwithantioxidantsystemsincaseofcolorectaltumors AT bgborzenko correlationofprooxidantwithantioxidantsystemsincaseofcolorectaltumors AT ovzuikova correlationofprooxidantwithantioxidantsystemsincaseofcolorectaltumors |