Sol-gel synthesized TiO2-chitosan nanocomposite as antibacterial coating for orthopedic implants: Investigation of properties and antimicrobial mechanisms
This study investigates the development of surface-modified titanium alloy implants through sol-gel synthesis to prevent bacterial infections while maintaining biocompatibility. The optimized 50:50 TiO₂:chitosan nanocomposite coating exhibited superior performance characteristics, with AFM analysis...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-10-01
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| Series: | Alexandria Engineering Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110016825007756 |
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| Summary: | This study investigates the development of surface-modified titanium alloy implants through sol-gel synthesis to prevent bacterial infections while maintaining biocompatibility. The optimized 50:50 TiO₂:chitosan nanocomposite coating exhibited superior performance characteristics, with AFM analysis revealing controlled surface topography Ra = 78 ± 7 nm) and uniform particle distribution. Electrochemical measurements demonstrated enhanced corrosion resistance, with impedance modulus increasing from 3.2 × 10⁵ Ω·cm² for uncoated Ti6Al4V to 2.8 × 10⁶ Ω·cm² for the optimized coating at 0.01 Hz. The coating showed excellent mechanical stability with an adhesion strength of 15.4 MPa and critical load of 18.5 N. Live/dead bacterial staining and CLSM analysis revealed significant reduction in biofilm formation, with time-dependent studies showing rapid initial bacterial inhibition within 6 h (68.7 % for S. aureus, 64.5 % for E. coli) and sustained antimicrobial activity over 72 h (95.2 % for S. aureus, 93.1 % for E. coli). The coating maintained structural integrity and performance after 30-day immersion in simulated body fluid, demonstrating its potential for long-term implant protection. |
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| ISSN: | 1110-0168 |