Selective Laser Trabeculoplasty Outcomes in Phakic and Pseudophakic Patients: A Meta-Analysis
Purpose: To perform a meta-analysis to compare the efficacy of selective laser trabeculoplasty (SLT) in phakic and pseudophakic eyes. Methods: Scopus, Embase, PubMed, and gray literature were searched for studies comparing SLT outcomes in phakic and pseudophakic patients with open-angle glaucoma (OA...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-07-01
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| Series: | Journal of Current Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/joco.joco_285_23 |
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| _version_ | 1839639492012539904 |
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| author | Rushil Kumbhani Amanda Wong Aretha Zhu Paras Shah Tristan Tham Farihah Anwar Daniel Zhu |
| author_facet | Rushil Kumbhani Amanda Wong Aretha Zhu Paras Shah Tristan Tham Farihah Anwar Daniel Zhu |
| author_sort | Rushil Kumbhani |
| collection | DOAJ |
| description | Purpose:
To perform a meta-analysis to compare the efficacy of selective laser trabeculoplasty (SLT) in phakic and pseudophakic eyes.
Methods:
Scopus, Embase, PubMed, and gray literature were searched for studies comparing SLT outcomes in phakic and pseudophakic patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). The mean change in intraocular pressure was compared using a standardized mean difference (SMD) meta-analysis (RevMan 5.4.1). Begg’s funnel plots and Egger’s test were used to assess publication bias.
Results:
Eleven studies with 1058 eyes (323 pseudophakic and 735 phakic) were identified. There was no statistically significant difference in the observed efficacy of SLT between pseudophakic and phakic eyes (SMD = −0.10; 95% confidence interval = −0.24, 0.03; P = 0.14). There was no publication bias or heterogeneity (I2 = 0%; P = 0.66) detected. Subgroup analysis of studies stratified by length of follow-up in months (6, 12, and 24 or greater) revealed no significant difference in SLT efficacy at the different time points (P = 0.86, P = 0.59, and P = 0.16, respectively).
Conclusions:
Our pooled and subgroup analysis revealed no significant difference in SLT response between the two populations. Our results support SLT as a viable treatment option for patients with OAG or OHT regardless of pseudophakic status. |
| format | Article |
| id | doaj-art-aeca9aab25c84e76b918d23d4a58e36e |
| institution | Matheson Library |
| issn | 2452-2325 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Current Ophthalmology |
| spelling | doaj-art-aeca9aab25c84e76b918d23d4a58e36e2025-07-04T09:14:52ZengWolters Kluwer Medknow PublicationsJournal of Current Ophthalmology2452-23252024-07-0136324225110.4103/joco.joco_285_23Selective Laser Trabeculoplasty Outcomes in Phakic and Pseudophakic Patients: A Meta-AnalysisRushil KumbhaniAmanda WongAretha ZhuParas ShahTristan ThamFarihah AnwarDaniel ZhuPurpose: To perform a meta-analysis to compare the efficacy of selective laser trabeculoplasty (SLT) in phakic and pseudophakic eyes. Methods: Scopus, Embase, PubMed, and gray literature were searched for studies comparing SLT outcomes in phakic and pseudophakic patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). The mean change in intraocular pressure was compared using a standardized mean difference (SMD) meta-analysis (RevMan 5.4.1). Begg’s funnel plots and Egger’s test were used to assess publication bias. Results: Eleven studies with 1058 eyes (323 pseudophakic and 735 phakic) were identified. There was no statistically significant difference in the observed efficacy of SLT between pseudophakic and phakic eyes (SMD = −0.10; 95% confidence interval = −0.24, 0.03; P = 0.14). There was no publication bias or heterogeneity (I2 = 0%; P = 0.66) detected. Subgroup analysis of studies stratified by length of follow-up in months (6, 12, and 24 or greater) revealed no significant difference in SLT efficacy at the different time points (P = 0.86, P = 0.59, and P = 0.16, respectively). Conclusions: Our pooled and subgroup analysis revealed no significant difference in SLT response between the two populations. Our results support SLT as a viable treatment option for patients with OAG or OHT regardless of pseudophakic status.https://journals.lww.com/10.4103/joco.joco_285_23meta-analysisocular hypertensionopen-angle glaucomaphakicpseudophakicselective laser trabeculoplasty |
| spellingShingle | Rushil Kumbhani Amanda Wong Aretha Zhu Paras Shah Tristan Tham Farihah Anwar Daniel Zhu Selective Laser Trabeculoplasty Outcomes in Phakic and Pseudophakic Patients: A Meta-Analysis Journal of Current Ophthalmology meta-analysis ocular hypertension open-angle glaucoma phakic pseudophakic selective laser trabeculoplasty |
| title | Selective Laser Trabeculoplasty Outcomes in Phakic and Pseudophakic Patients: A Meta-Analysis |
| title_full | Selective Laser Trabeculoplasty Outcomes in Phakic and Pseudophakic Patients: A Meta-Analysis |
| title_fullStr | Selective Laser Trabeculoplasty Outcomes in Phakic and Pseudophakic Patients: A Meta-Analysis |
| title_full_unstemmed | Selective Laser Trabeculoplasty Outcomes in Phakic and Pseudophakic Patients: A Meta-Analysis |
| title_short | Selective Laser Trabeculoplasty Outcomes in Phakic and Pseudophakic Patients: A Meta-Analysis |
| title_sort | selective laser trabeculoplasty outcomes in phakic and pseudophakic patients a meta analysis |
| topic | meta-analysis ocular hypertension open-angle glaucoma phakic pseudophakic selective laser trabeculoplasty |
| url | https://journals.lww.com/10.4103/joco.joco_285_23 |
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