Thyroid function and metabolic profile in women during the first trimester of pregnancy: A cross-sectional comparative study
Maternal thyroid hormones are critical for fetal development, particularly during the first trimester when the fetus relies entirely on maternal supply. This cross-sectional study assessed thyroid function in 85 first-trimester pregnant women and 85 age-matched non-pregnant controls in IBB City, Ye...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Land Measurements and Cadastre from Transylvania (SMTCT)
2025-06-01
|
| Series: | Notulae Scientia Biologicae |
| Subjects: | |
| Online Access: | https://www.notulaebiologicae.ro/index.php/nsb/article/view/12555 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Maternal thyroid hormones are critical for fetal development, particularly during the first trimester when the fetus relies entirely on maternal supply. This cross-sectional study assessed thyroid function in 85 first-trimester pregnant women and 85 age-matched non-pregnant controls in IBB City, Yemen. Serum levels of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured using enzyme-linked immunosorbent assay (ELISA) kits. The mean TSH and FT4 levels in pregnant women (2.16 ± 1.71 mIU/L and 1.28 ± 0.48 ng/dL, respectively) did not differ significantly from those in non-pregnant women (2.20 ± 1.40 mIU/L and 1.32 ± 0.42 ng/dL), with no clinically evident cases of overt thyroid dysfunction observed. A strong inverse correlation was found between FT4 and TSH in the pregnant group (r = –0.659, p < 0.001). No significant associations were detected between thyroid hormone levels and gestational age, obstetric history, or family history. Age-related declines in FT4 and FT3 were noted in controls but not in pregnant participants. These findings suggest stable first-trimester thyroid function in this cohort, though high dysfunction rates (24.7% subclinical; 10.6% overt hypothyroidism) indicate regional susceptibility. Given this burden, targeted screening could identify subclinical dysfunction and inform local reference intervals.
|
|---|---|
| ISSN: | 2067-3264 |