An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment
Background: Aging is a natural process that cannot be stopped but retarded. Hydroxypinacolone retinoate (HPR) is a potent anti-wrinkle agent, but with severe irritancy, low stability, and poor water solubility, making it hard to apply in cosmetics. Ionic liquid (IL), as a solvent, displayed improved...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Journal of Dermatologic Science and Cosmetic Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950306X2400044X |
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| author | Huixian Xu Qiaomei Huang Jingyao Gan De Bai Bo Yang Zhenyuan Wang Jichuan Zhang Chengyu Wu Jiaheng Zhang |
| author_facet | Huixian Xu Qiaomei Huang Jingyao Gan De Bai Bo Yang Zhenyuan Wang Jichuan Zhang Chengyu Wu Jiaheng Zhang |
| author_sort | Huixian Xu |
| collection | DOAJ |
| description | Background: Aging is a natural process that cannot be stopped but retarded. Hydroxypinacolone retinoate (HPR) is a potent anti-wrinkle agent, but with severe irritancy, low stability, and poor water solubility, making it hard to apply in cosmetics. Ionic liquid (IL), as a solvent, displayed improved transdermal efficiency. The role of nano-encapsulation technology in addressing the disadvantages of efficacy application is significant. Objective: Using a combination of ionic liquids and nano-encapsulation technology to obtain HPR-encapsulated ionic liquid nanoparticles (HPR IL-NPs) is an innovative formulation used as a serum, emulsion, and cream in cosmetics for effective anti-wrinkle. Methods: HPR IL-NPs were prepared using matrine coconut oil ionic liquid as a surfactant and permeation enhancer combined with high-pressure homogenization. Results: The average particle size in the obtained HPR IL-NPs was 92.8 nm. Applying the HPR IL-NPs increased the content of active substances in the skin by 3.6-fold compared to a traditional HPR-loaded cream. The chick chorioallantois membrane assay showed an RC50 > 100 %, and repeated skin-irritation tests resulted in a mean value of 0.00 points per animal per day. The HPR IL-NPs showed continuous release for 24 h in vitro in the continuous release test. At the same time, the HPR IL-NPs significantly reduced irritation induced by HPR alone. The number and area of facial wrinkles decreased by 25.09 % and 23.65 %, respectively, after one week of application of liquid cream on volunteers. Conclusion: IL NPs can significantly improve transdermal absorption efficiency, reduce irritation, and demonstrate high anti-wrinkle efficiency. Supramolecular liquid cream is a promising product in cosmetics for skin care. |
| format | Article |
| id | doaj-art-adb2b8bec1f84d8da8c7ad0372c858cf |
| institution | Matheson Library |
| issn | 2950-306X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Dermatologic Science and Cosmetic Technology |
| spelling | doaj-art-adb2b8bec1f84d8da8c7ad0372c858cf2025-07-31T04:54:25ZengKeAi Communications Co., Ltd.Journal of Dermatologic Science and Cosmetic Technology2950-306X2024-12-0114100046An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatmentHuixian Xu0Qiaomei Huang1Jingyao Gan2De Bai3Bo Yang4Zhenyuan Wang5Jichuan Zhang6Chengyu Wu7Jiaheng Zhang8Sauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, ChinaDepartment of Raw Material Reseach, Shenzhen Shinehigh Innovation Technology Co., Ltd., Shenzhen 518055, ChinaDepartment of Pharmaceutical Sciences and the Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USASauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, ChinaDepartment of Raw Material Reseach, Shenzhen Shinehigh Innovation Technology Co., Ltd., Shenzhen 518055, ChinaDepartment of Raw Material Reseach, Shenzhen Shinehigh Innovation Technology Co., Ltd., Shenzhen 518055, ChinaSauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, ChinaCollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China; Corresponding authors.Sauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, China; Corresponding authors.Background: Aging is a natural process that cannot be stopped but retarded. Hydroxypinacolone retinoate (HPR) is a potent anti-wrinkle agent, but with severe irritancy, low stability, and poor water solubility, making it hard to apply in cosmetics. Ionic liquid (IL), as a solvent, displayed improved transdermal efficiency. The role of nano-encapsulation technology in addressing the disadvantages of efficacy application is significant. Objective: Using a combination of ionic liquids and nano-encapsulation technology to obtain HPR-encapsulated ionic liquid nanoparticles (HPR IL-NPs) is an innovative formulation used as a serum, emulsion, and cream in cosmetics for effective anti-wrinkle. Methods: HPR IL-NPs were prepared using matrine coconut oil ionic liquid as a surfactant and permeation enhancer combined with high-pressure homogenization. Results: The average particle size in the obtained HPR IL-NPs was 92.8 nm. Applying the HPR IL-NPs increased the content of active substances in the skin by 3.6-fold compared to a traditional HPR-loaded cream. The chick chorioallantois membrane assay showed an RC50 > 100 %, and repeated skin-irritation tests resulted in a mean value of 0.00 points per animal per day. The HPR IL-NPs showed continuous release for 24 h in vitro in the continuous release test. At the same time, the HPR IL-NPs significantly reduced irritation induced by HPR alone. The number and area of facial wrinkles decreased by 25.09 % and 23.65 %, respectively, after one week of application of liquid cream on volunteers. Conclusion: IL NPs can significantly improve transdermal absorption efficiency, reduce irritation, and demonstrate high anti-wrinkle efficiency. Supramolecular liquid cream is a promising product in cosmetics for skin care.http://www.sciencedirect.com/science/article/pii/S2950306X2400044XLiquid creamIonic liquidTransdermal deliveryLong-actingAnti-wrinkle |
| spellingShingle | Huixian Xu Qiaomei Huang Jingyao Gan De Bai Bo Yang Zhenyuan Wang Jichuan Zhang Chengyu Wu Jiaheng Zhang An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment Journal of Dermatologic Science and Cosmetic Technology Liquid cream Ionic liquid Transdermal delivery Long-acting Anti-wrinkle |
| title | An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment |
| title_full | An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment |
| title_fullStr | An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment |
| title_full_unstemmed | An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment |
| title_short | An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment |
| title_sort | ionic liquid nanoparticles for dermal targeted delivery and effective anti wrinkle treatment |
| topic | Liquid cream Ionic liquid Transdermal delivery Long-acting Anti-wrinkle |
| url | http://www.sciencedirect.com/science/article/pii/S2950306X2400044X |
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