An ionic liquid nanoparticles for dermal targeted delivery and effective anti-wrinkle treatment
Background: Aging is a natural process that cannot be stopped but retarded. Hydroxypinacolone retinoate (HPR) is a potent anti-wrinkle agent, but with severe irritancy, low stability, and poor water solubility, making it hard to apply in cosmetics. Ionic liquid (IL), as a solvent, displayed improved...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Journal of Dermatologic Science and Cosmetic Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950306X2400044X |
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| Summary: | Background: Aging is a natural process that cannot be stopped but retarded. Hydroxypinacolone retinoate (HPR) is a potent anti-wrinkle agent, but with severe irritancy, low stability, and poor water solubility, making it hard to apply in cosmetics. Ionic liquid (IL), as a solvent, displayed improved transdermal efficiency. The role of nano-encapsulation technology in addressing the disadvantages of efficacy application is significant. Objective: Using a combination of ionic liquids and nano-encapsulation technology to obtain HPR-encapsulated ionic liquid nanoparticles (HPR IL-NPs) is an innovative formulation used as a serum, emulsion, and cream in cosmetics for effective anti-wrinkle. Methods: HPR IL-NPs were prepared using matrine coconut oil ionic liquid as a surfactant and permeation enhancer combined with high-pressure homogenization. Results: The average particle size in the obtained HPR IL-NPs was 92.8 nm. Applying the HPR IL-NPs increased the content of active substances in the skin by 3.6-fold compared to a traditional HPR-loaded cream. The chick chorioallantois membrane assay showed an RC50 > 100 %, and repeated skin-irritation tests resulted in a mean value of 0.00 points per animal per day. The HPR IL-NPs showed continuous release for 24 h in vitro in the continuous release test. At the same time, the HPR IL-NPs significantly reduced irritation induced by HPR alone. The number and area of facial wrinkles decreased by 25.09 % and 23.65 %, respectively, after one week of application of liquid cream on volunteers. Conclusion: IL NPs can significantly improve transdermal absorption efficiency, reduce irritation, and demonstrate high anti-wrinkle efficiency. Supramolecular liquid cream is a promising product in cosmetics for skin care. |
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| ISSN: | 2950-306X |