Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older
Purpose The aim of this study was to examine the prognosis and associated risk factors, including adjuvant chemotherapy (CTx), in elderly patients with colon cancer. Methods This retrospective study included patients who underwent radical resection for colon cancer between January 2010 and December...
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Korean Society of Coloproctology
2025-06-01
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| Series: | Annals of Coloproctology |
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| Online Access: | http://coloproctol.org/upload/pdf/ac-2023-00367-0052.pdf |
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| author | Byeo Lee Lim In Ja Park Jun-Soo Ro Young Il Kim Seok-Byung Lim Chang Sik Yu |
| author_facet | Byeo Lee Lim In Ja Park Jun-Soo Ro Young Il Kim Seok-Byung Lim Chang Sik Yu |
| author_sort | Byeo Lee Lim |
| collection | DOAJ |
| description | Purpose The aim of this study was to examine the prognosis and associated risk factors, including adjuvant chemotherapy (CTx), in elderly patients with colon cancer. Methods This retrospective study included patients who underwent radical resection for colon cancer between January 2010 and December 2014 at Asan Medical Center. The effects of stage, risk factors, and chemotherapy on overall survival (OS) and recurrence-free survival (RFS) were compared in patients aged ≥70 and <70 years. Results Of 3,313 patients, 933 (28.1%) was aged ≥70 years. Of the 1,921 patients indicated for adjuvant CTx, 1,294 of 1,395 patients (92.8%) aged <70 years and 369 of 526 patients (70.2%) aged ≥70 years received adjuvant CTx. Old age (≥70 years) was independently associated with RFS in overall cohort. Among patients aged ≥70 years indicated for adjuvant CTx, the 5-year OS (81.6% vs. 50.4%, P<0.001) and RFS (82.9% vs. 67.4%, P=0.025) rates were significantly higher in those who did than did not receive adjuvant CTx. Additionally, adjuvant CTx was confirmed as an independent risk factor of both OS and RFS in patients aged ≥70 years indicated for adjuvant CTx. Conclusion Old age was associated with poor RFS and adjuvant CTx had benefits in OS as well as RFS in elderly patients eligible for adjuvant CTx. |
| format | Article |
| id | doaj-art-adae6e16e37b4aa6851bcd9b35f2b7a6 |
| institution | Matheson Library |
| issn | 2287-9714 2287-9722 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Korean Society of Coloproctology |
| record_format | Article |
| series | Annals of Coloproctology |
| spelling | doaj-art-adae6e16e37b4aa6851bcd9b35f2b7a62025-07-02T07:39:41ZengKorean Society of ColoproctologyAnnals of Coloproctology2287-97142287-97222025-06-0141319820610.3393/ac.2023.00367.00522024Oncologic outcomes and associated factors of colon cancer patients aged 70 years and olderByeo Lee Lim0In Ja Park1Jun-Soo Ro2Young Il Kim3Seok-Byung Lim4Chang Sik Yu5 Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Colon and Rectal Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, KoreaPurpose The aim of this study was to examine the prognosis and associated risk factors, including adjuvant chemotherapy (CTx), in elderly patients with colon cancer. Methods This retrospective study included patients who underwent radical resection for colon cancer between January 2010 and December 2014 at Asan Medical Center. The effects of stage, risk factors, and chemotherapy on overall survival (OS) and recurrence-free survival (RFS) were compared in patients aged ≥70 and <70 years. Results Of 3,313 patients, 933 (28.1%) was aged ≥70 years. Of the 1,921 patients indicated for adjuvant CTx, 1,294 of 1,395 patients (92.8%) aged <70 years and 369 of 526 patients (70.2%) aged ≥70 years received adjuvant CTx. Old age (≥70 years) was independently associated with RFS in overall cohort. Among patients aged ≥70 years indicated for adjuvant CTx, the 5-year OS (81.6% vs. 50.4%, P<0.001) and RFS (82.9% vs. 67.4%, P=0.025) rates were significantly higher in those who did than did not receive adjuvant CTx. Additionally, adjuvant CTx was confirmed as an independent risk factor of both OS and RFS in patients aged ≥70 years indicated for adjuvant CTx. Conclusion Old age was associated with poor RFS and adjuvant CTx had benefits in OS as well as RFS in elderly patients eligible for adjuvant CTx.http://coloproctol.org/upload/pdf/ac-2023-00367-0052.pdfagedcolonic neoplasmsadjuvant chemotherapyprognosis |
| spellingShingle | Byeo Lee Lim In Ja Park Jun-Soo Ro Young Il Kim Seok-Byung Lim Chang Sik Yu Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older Annals of Coloproctology aged colonic neoplasms adjuvant chemotherapy prognosis |
| title | Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older |
| title_full | Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older |
| title_fullStr | Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older |
| title_full_unstemmed | Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older |
| title_short | Oncologic outcomes and associated factors of colon cancer patients aged 70 years and older |
| title_sort | oncologic outcomes and associated factors of colon cancer patients aged 70 years and older |
| topic | aged colonic neoplasms adjuvant chemotherapy prognosis |
| url | http://coloproctol.org/upload/pdf/ac-2023-00367-0052.pdf |
| work_keys_str_mv | AT byeoleelim oncologicoutcomesandassociatedfactorsofcoloncancerpatientsaged70yearsandolder AT injapark oncologicoutcomesandassociatedfactorsofcoloncancerpatientsaged70yearsandolder AT junsooro oncologicoutcomesandassociatedfactorsofcoloncancerpatientsaged70yearsandolder AT youngilkim oncologicoutcomesandassociatedfactorsofcoloncancerpatientsaged70yearsandolder AT seokbyunglim oncologicoutcomesandassociatedfactorsofcoloncancerpatientsaged70yearsandolder AT changsikyu oncologicoutcomesandassociatedfactorsofcoloncancerpatientsaged70yearsandolder |