Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions
Vaccination campaigns have profoundly influenced the dynamics of infectious diseases, acting as one of the largest ecological experiments in history. By vaccinating billions across decades, we have imposed powerful selective pressures on pathogens, illuminating their ability to adapt, evade, or pers...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Parasitology and Vector-Borne Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667114X25000512 |
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| author | Ana Laura Cano-Argüelles Lianet Abuin-Denis Dasiel Obregon Lourdes Mateos-Hernandez Apolline Maître Elianne Piloto-Sardiñas Alejandra Wu-Chuang Pierre Tonnerre Alejandro Cabezas-Cruz |
| author_facet | Ana Laura Cano-Argüelles Lianet Abuin-Denis Dasiel Obregon Lourdes Mateos-Hernandez Apolline Maître Elianne Piloto-Sardiñas Alejandra Wu-Chuang Pierre Tonnerre Alejandro Cabezas-Cruz |
| author_sort | Ana Laura Cano-Argüelles |
| collection | DOAJ |
| description | Vaccination campaigns have profoundly influenced the dynamics of infectious diseases, acting as one of the largest ecological experiments in history. By vaccinating billions across decades, we have imposed powerful selective pressures on pathogens, illuminating their ability to adapt, evade, or persist. Rooted in the Jenner/Pasteur paradigm – where exposure to an antigen induces protective immunity – vaccines have revealed how pathogens differ in their ecological susceptibility to immunity. Using this framework, pathogens can be categorized based on their strategies to endure, from those limited by direct immunity to those relying on antigenic variation, chronic infection, or reservoirs. Vector-borne pathogens (VBPs) present a set of challenges to vaccination efforts due to their complex life cycles, stage-specific antigen expression, and reliance on arthropod vectors for transmission. These pathogens not only evade host immunity but also adapt to selective pressures within the vector’s microbiome and immune system. Such complexity often places VBPs beyond the scope of traditional vaccine paradigms, requiring alternative strategies such as transmission-blocking and vector-targeted vaccines. This review explores these insights, examining the interplay between vaccination, pathogen ecology, and evolution – with special emphasis on VBPs – to guide future strategies in vector-borne disease (VBD) control. |
| format | Article |
| id | doaj-art-adacea765fef4f8f80bbd75abf4b83d0 |
| institution | Matheson Library |
| issn | 2667-114X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Parasitology and Vector-Borne Diseases |
| spelling | doaj-art-adacea765fef4f8f80bbd75abf4b83d02025-07-16T04:56:35ZengElsevierCurrent Research in Parasitology and Vector-Borne Diseases2667-114X2025-01-018100291Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactionsAna Laura Cano-Argüelles0Lianet Abuin-Denis1Dasiel Obregon2Lourdes Mateos-Hernandez3Apolline Maître4Elianne Piloto-Sardiñas5Alejandra Wu-Chuang6Pierre Tonnerre7Alejandro Cabezas-Cruz8Parasitology Laboratory, Institute of Natural Resources and Agrobiology of Salamanca (IRNASA, CSIC), Cordel de Merinas, 40-52, 37008, Salamanca, SpainAnses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, Maisons-Alfort, F-94700, France; Animal Biotechnology Department, Center for Genetic Engineering and Biotechnology, Avenue 31 between 158 and 190, P.O. Box 6162, Havana, 10600, CubaSchool of Environmental Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON, N1H 2W1, CanadaAnses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, Maisons-Alfort, F-94700, FranceAnses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, Maisons-Alfort, F-94700, FranceAnses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, Maisons-Alfort, F-94700, France; Direction of Animal Health, National Center for Animal and Plant Health, Carretera de Tapaste y Autopista Nacional, Apartado Postal 10, San José de las Lajas, 32700, Mayabeque, CubaAnses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, Maisons-Alfort, F-94700, FranceInstitut de Recherche Saint-Louis, Université Paris-Cité, Inserm U976, Team ATIP-Avenir, Paris, France; Corresponding author.Anses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, Maisons-Alfort, F-94700, France; Corresponding author.Vaccination campaigns have profoundly influenced the dynamics of infectious diseases, acting as one of the largest ecological experiments in history. By vaccinating billions across decades, we have imposed powerful selective pressures on pathogens, illuminating their ability to adapt, evade, or persist. Rooted in the Jenner/Pasteur paradigm – where exposure to an antigen induces protective immunity – vaccines have revealed how pathogens differ in their ecological susceptibility to immunity. Using this framework, pathogens can be categorized based on their strategies to endure, from those limited by direct immunity to those relying on antigenic variation, chronic infection, or reservoirs. Vector-borne pathogens (VBPs) present a set of challenges to vaccination efforts due to their complex life cycles, stage-specific antigen expression, and reliance on arthropod vectors for transmission. These pathogens not only evade host immunity but also adapt to selective pressures within the vector’s microbiome and immune system. Such complexity often places VBPs beyond the scope of traditional vaccine paradigms, requiring alternative strategies such as transmission-blocking and vector-targeted vaccines. This review explores these insights, examining the interplay between vaccination, pathogen ecology, and evolution – with special emphasis on VBPs – to guide future strategies in vector-borne disease (VBD) control.http://www.sciencedirect.com/science/article/pii/S2667114X25000512VaccinationPathogen ecologyJenner/Pasteur paradigmVector-borne pathogenPathogen adaptationPublic health strategies |
| spellingShingle | Ana Laura Cano-Argüelles Lianet Abuin-Denis Dasiel Obregon Lourdes Mateos-Hernandez Apolline Maître Elianne Piloto-Sardiñas Alejandra Wu-Chuang Pierre Tonnerre Alejandro Cabezas-Cruz Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions Current Research in Parasitology and Vector-Borne Diseases Vaccination Pathogen ecology Jenner/Pasteur paradigm Vector-borne pathogen Pathogen adaptation Public health strategies |
| title | Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions |
| title_full | Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions |
| title_fullStr | Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions |
| title_full_unstemmed | Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions |
| title_short | Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions |
| title_sort | why the jenner pasteur paradigm is insufficient for controlling vector borne diseases and the role of microbiota mediated interactions |
| topic | Vaccination Pathogen ecology Jenner/Pasteur paradigm Vector-borne pathogen Pathogen adaptation Public health strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2667114X25000512 |
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