Rapid cochlear gene therapy in adult deaf mice: Vglut3 rescue via AAV8 achieves day-1 hearing restoration

Genetic hearing loss, caused by mutations in critical auditory genes, has seen promising advances through gene therapy, yet the temporal dynamics of early-stage auditory functional recovery and therapeutic transgene expression patterns following intervention remain uncharacterized in preclinical dea...

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Bibliographic Details
Main Authors: Ting Zhang, Rongqun Zhai, Mengli Liu, Hongen Xu, Liang Wang, Wenxue Tang, Bei Chen, Xingle Zhao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Methods & Clinical Development
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Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125001342
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