Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines
Shanlei Zhou,1 Yu Zhang,1 Eudald Casals,2 Muling Zeng,3 Manuel Morales-Ruiz,4,5 Qingshi Liu,6 Bo Zhang,7 Gregori Casals4,8 1Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People’s Republic of China; 2Premium Research SL, Guadalajara, 19003, Spa...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-06-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/mesoporous-silica-encapsulated-cerium-oxide-nanozymes-and-quercetin-fo-peer-reviewed-fulltext-article-IJN |
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| Summary: | Shanlei Zhou,1 Yu Zhang,1 Eudald Casals,2 Muling Zeng,3 Manuel Morales-Ruiz,4,5 Qingshi Liu,6 Bo Zhang,7 Gregori Casals4,8 1Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People’s Republic of China; 2Premium Research SL, Guadalajara, 19003, Spain; 3Materials Science Institute of Barcelona (ICMAB-CSIC), Bellaterra, 08193, Spain; 4CDB, Hospital Clínic of Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain; 5Department of Biomedicine, Faculty of Medicine and Health Science, University of Barcelona, Barcelona, 08036, Spain; 6State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People’s Republic of China; 7The First Clinical Medical College of Anhui University of Chinese Medicine, Hefei, 230031, People’s Republic of China; 8Department of Fundamental and Clinical Nursing, Faculty of Nursing, University of Barcelona, L’Hospitalet de Llobregat, 08907, SpainCorrespondence: Qingshi Liu, Email qsliu@ciac.ac.cn Bo Zhang, Email 13956934348@139.comIntroduction: Combining natural antioxidants with nanozymes represents a promising strategy to enhance therapeutic outcomes in oxidative stress-related diseases. This study integrates quercetin (Que), a plant-derived flavonoid with strong antioxidant activity, and cerium oxide nanozymes (CeO2NZs) into mesoporous silica (mSiO2) to enhance therapeutic efficacy and overcome the poor solubility and bioavailability of natural antioxidants.Methods: Large-pore mSiO₂ (11 nm) were synthesized via a sol–gel method to encapsulate cerium oxide nanozymes (CeO₂NZs). Que was loaded using solvent impregnation to obtain (CeO₂/Que)@mSiO₂ nanocomposites. Structural and chemical characterization was performed, and biological evaluations were conducted in A549 cells.Results: The incorporation of a large mesopore mSiO₂ (11 nm) significantly enhanced Que loading capacity and its sustained release in cell culture media. The (CeO₂/Que)@mSiO₂ nanocomposite demonstrated excellent biocompatibility, effective ROS scavenging, and significant downregulation of inflammatory cytokines (IL-1β, IL-6, TNF-α) compared to free Que.Conclusion: The (CeO₂/Que)@mSiO₂ nanoplatform offers synergistic antioxidant and anti-inflammatory effects, supporting its potential for treating oxidative stress-related inflammatory conditions. Keywords: quercetin, cerium oxide nanoparticles, nanozymes, oxidative stress, chronic inflammation |
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| ISSN: | 1178-2013 |