The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinoma
Given the favorable prognosis associated with HPV-positive oropharyngeal cancer, cancer care professionals are actively discussing the feasibility of de-escalating treatment strategy for this cohort of patients.The purpose of the study was to improve the treatment outcomes in patients with locally a...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2023-05-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/2525 |
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| author | P. V. Golubev L. V. Bolotina A. R. Gevorkov T. I. Deshkina A. V. Boyko A. D. Kaprin |
| author_facet | P. V. Golubev L. V. Bolotina A. R. Gevorkov T. I. Deshkina A. V. Boyko A. D. Kaprin |
| author_sort | P. V. Golubev |
| collection | DOAJ |
| description | Given the favorable prognosis associated with HPV-positive oropharyngeal cancer, cancer care professionals are actively discussing the feasibility of de-escalating treatment strategy for this cohort of patients.The purpose of the study was to improve the treatment outcomes in patients with locally advanced HPV- positive oropharyngeal squamous cell carcinoma by identifying the optimal induction chemotherapy (ICH) regimen, in particular, by using a two-drug ICH.Material and Methods. The study included 27 patients with locally advanced (T3–4N0–1, or T1–4N2–3) P16-positive oropharyngeal squamous cell carcinoma. All patients received 3 cycles of ICT according to the TP (docetaxel + cisplatin) regimen. To assess the effect and toxicity of two-drug ICH, a control group of patients, who received ICH according to the standard three-drug TPF (docetaxel, cisplatin and 5FU) regimen, was formed.Results. In the TP group, complete response (CR) was achieved in 3 (11 %) patients, partial response (PR) in 17 (63 %), stable disease (SD) in 7 (26 %) patients. In the control group: CR 4 (20 %) patients, PR – 13 (60 %), SD – 4 (20 %) patients. The median follow-up time in the TP group was 9 months (range: 2 to 22 months). The 1-year progression-free (PFS) and overall survival (OS) rates were 88.2 % and 100 %, respectively. In the TPF group, the PFS and OS rates were 84.4 % and 100 %, respectively.Conclusion. The results revealed that TP ICH regimen was non-inferior to the standard TPF regimen in the rates of the objective response, 1-year OS and PFS. |
| format | Article |
| id | doaj-art-ac1d2f1dfc6144ef9b51e377dbfe3812 |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-ac1d2f1dfc6144ef9b51e377dbfe38122025-08-04T10:33:43ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682023-05-01222263310.21294/1814-4861-2023-22-2-26-331101The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinomaP. V. Golubev0L. V. Bolotina1A. R. Gevorkov2T. I. Deshkina3A. V. Boyko4A. D. Kaprin5P.A. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the RussiaP.A. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the RussiaP.A. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the RussiaP.A. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the RussiaP.A. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the RussiaP.A. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russia; National Medical Research Radiological Centre of the Ministry of Health of the Russia; RUDN UniversityGiven the favorable prognosis associated with HPV-positive oropharyngeal cancer, cancer care professionals are actively discussing the feasibility of de-escalating treatment strategy for this cohort of patients.The purpose of the study was to improve the treatment outcomes in patients with locally advanced HPV- positive oropharyngeal squamous cell carcinoma by identifying the optimal induction chemotherapy (ICH) regimen, in particular, by using a two-drug ICH.Material and Methods. The study included 27 patients with locally advanced (T3–4N0–1, or T1–4N2–3) P16-positive oropharyngeal squamous cell carcinoma. All patients received 3 cycles of ICT according to the TP (docetaxel + cisplatin) regimen. To assess the effect and toxicity of two-drug ICH, a control group of patients, who received ICH according to the standard three-drug TPF (docetaxel, cisplatin and 5FU) regimen, was formed.Results. In the TP group, complete response (CR) was achieved in 3 (11 %) patients, partial response (PR) in 17 (63 %), stable disease (SD) in 7 (26 %) patients. In the control group: CR 4 (20 %) patients, PR – 13 (60 %), SD – 4 (20 %) patients. The median follow-up time in the TP group was 9 months (range: 2 to 22 months). The 1-year progression-free (PFS) and overall survival (OS) rates were 88.2 % and 100 %, respectively. In the TPF group, the PFS and OS rates were 84.4 % and 100 %, respectively.Conclusion. The results revealed that TP ICH regimen was non-inferior to the standard TPF regimen in the rates of the objective response, 1-year OS and PFS.https://www.siboncoj.ru/jour/article/view/2525squamous cell carcinomaoropharyngeal carcinomahuman papillomavirusinduction chemotherapytoxicitysurvival |
| spellingShingle | P. V. Golubev L. V. Bolotina A. R. Gevorkov T. I. Deshkina A. V. Boyko A. D. Kaprin The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinoma Сибирский онкологический журнал squamous cell carcinoma oropharyngeal carcinoma human papillomavirus induction chemotherapy toxicity survival |
| title | The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinoma |
| title_full | The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinoma |
| title_fullStr | The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinoma |
| title_full_unstemmed | The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinoma |
| title_short | The effectiveness of a dual-component regimen of induction chemotherapy in the treatment of HPV-positive oropharyngeal squamous cell carcinoma |
| title_sort | effectiveness of a dual component regimen of induction chemotherapy in the treatment of hpv positive oropharyngeal squamous cell carcinoma |
| topic | squamous cell carcinoma oropharyngeal carcinoma human papillomavirus induction chemotherapy toxicity survival |
| url | https://www.siboncoj.ru/jour/article/view/2525 |
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