Endotelioand cardioprotective effects of HMG-Co-A reductase in endotoksininducing endotelial dysfunction
The use of inhibitors of HMG-Co-A reductase inhibitor simvastatin, atorvastatin, rosuvastatin and nanoparticulative rosuvastatin on background modeling endotoksininducing pathology, introduction of strain 603 Staphylococcusaureus leads to the development of dose-response endotelioprotectiv action, e...
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Main Authors: | , , , , , , |
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Format: | Article |
Language: | Russian |
Published: |
Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2015-10-01
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Series: | Кубанский научный медицинский вестник |
Subjects: | |
Online Access: | https://ksma.elpub.ru/jour/article/view/389 |
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Summary: | The use of inhibitors of HMG-Co-A reductase inhibitor simvastatin, atorvastatin, rosuvastatin and nanoparticulative rosuvastatin on background modeling endotoksininducing pathology, introduction of strain 603 Staphylococcusaureus leads to the development of dose-response endotelioprotectiv action, expressed in the normalization of QED, prevent increase adrenoreactivity and exhaustion of myocardial reserve and and normalization of biochemical markers of inflammation (C-reactive protein) and the level of proinflammatory cytokines. When this is detected positive dynamics and-products of NO and expression of eNOS. |
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ISSN: | 1608-6228 2541-9544 |