Prevalence and risk factors of metabolic associated fatty liver disease in lean patients with bipolar disorder: a retrospective cross-sectional study
BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) in lean individuals indicates metabolic dysfunction and elevates risks of metabolic and cardiovascular diseases. Thus far, no studies have specifically examined the prevalence and risk factors of MAFLD in lean individuals with bi...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1605484/full |
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| author | Weihong Lei Weihong Lei Weihong Lei Jiahuan Li Jiahuan Li Jiahuan Li Yiyi Liu Yiyi Liu Yiyi Liu Ying Wang Ying Wang Qing Wu Qing Wu Qing Wu |
| author_facet | Weihong Lei Weihong Lei Weihong Lei Jiahuan Li Jiahuan Li Jiahuan Li Yiyi Liu Yiyi Liu Yiyi Liu Ying Wang Ying Wang Qing Wu Qing Wu Qing Wu |
| author_sort | Weihong Lei |
| collection | DOAJ |
| description | BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) in lean individuals indicates metabolic dysfunction and elevates risks of metabolic and cardiovascular diseases. Thus far, no studies have specifically examined the prevalence and risk factors of MAFLD in lean individuals with bipolar disorder.MethodsThis retrospective study included 1,072 patients aged 18 to 60 years. Participants were classified into two groups based on their Body Mass Index (BMI): those with a BMI ≥24 kg/m² were categorized as overweight or obese, while those with a BMI <24 kg/m² were defined as lean. Data were extracted from inpatient records at the Anhui Mental Health Center.ResultsMAFLD prevalence markedly differed between groups (lean: 10.5% vs. overweight/obese: 76.3%, p<0.001). Among lean BD patients, MAFLD-positive and MAFLD-negative subgroups significantly differed in: age, onset age, illness duration, BMI, ALT, key metabolic indices, marital status, diabetes, and hypertension. Stepwise binary logistic regression analysis revealed that fasting blood glucose level, triglyceride level, gamma-glutamyl transferase (GGT) level, female gender and diabetes status were significant risk factors for MAFLD, while high-density lipoprotein (HDL) level was identified as a protective factor.ConclusionMAFLD is clinically relevant in lean BD patients. Fasting blood glucose level, triglyceride level, GGT level, female gender, and diabetes status were significant risk factors for MAFLD, whereas HDL level was a significant protective factor. Given the potential harm of MAFLD, it is essential to enhance vigilance and underscore the necessity of monitoring MAFLD among individuals with bipolar disorder, especially those who are lean. |
| format | Article |
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| institution | Matheson Library |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-ab9ef3f1054b443f9ca376f4f50ca85a2025-07-30T09:53:15ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.16054841605484Prevalence and risk factors of metabolic associated fatty liver disease in lean patients with bipolar disorder: a retrospective cross-sectional studyWeihong Lei0Weihong Lei1Weihong Lei2Jiahuan Li3Jiahuan Li4Jiahuan Li5Yiyi Liu6Yiyi Liu7Yiyi Liu8Ying Wang9Ying Wang10Qing Wu11Qing Wu12Qing Wu13School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaDepartment of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaAnhui Mental Health Center, Hefei Fourth People’s Hospital, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaDepartment of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaAnhui Mental Health Center, Hefei Fourth People’s Hospital, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaDepartment of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaAnhui Mental Health Center, Hefei Fourth People’s Hospital, Hefei, ChinaDepartment of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaAnhui Mental Health Center, Hefei Fourth People’s Hospital, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaDepartment of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaAnhui Mental Health Center, Hefei Fourth People’s Hospital, Hefei, ChinaBackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) in lean individuals indicates metabolic dysfunction and elevates risks of metabolic and cardiovascular diseases. Thus far, no studies have specifically examined the prevalence and risk factors of MAFLD in lean individuals with bipolar disorder.MethodsThis retrospective study included 1,072 patients aged 18 to 60 years. Participants were classified into two groups based on their Body Mass Index (BMI): those with a BMI ≥24 kg/m² were categorized as overweight or obese, while those with a BMI <24 kg/m² were defined as lean. Data were extracted from inpatient records at the Anhui Mental Health Center.ResultsMAFLD prevalence markedly differed between groups (lean: 10.5% vs. overweight/obese: 76.3%, p<0.001). Among lean BD patients, MAFLD-positive and MAFLD-negative subgroups significantly differed in: age, onset age, illness duration, BMI, ALT, key metabolic indices, marital status, diabetes, and hypertension. Stepwise binary logistic regression analysis revealed that fasting blood glucose level, triglyceride level, gamma-glutamyl transferase (GGT) level, female gender and diabetes status were significant risk factors for MAFLD, while high-density lipoprotein (HDL) level was identified as a protective factor.ConclusionMAFLD is clinically relevant in lean BD patients. Fasting blood glucose level, triglyceride level, GGT level, female gender, and diabetes status were significant risk factors for MAFLD, whereas HDL level was a significant protective factor. Given the potential harm of MAFLD, it is essential to enhance vigilance and underscore the necessity of monitoring MAFLD among individuals with bipolar disorder, especially those who are lean.https://www.frontiersin.org/articles/10.3389/fendo.2025.1605484/fullbipolar disorderMAFLDlean typeprevalencerisk factors |
| spellingShingle | Weihong Lei Weihong Lei Weihong Lei Jiahuan Li Jiahuan Li Jiahuan Li Yiyi Liu Yiyi Liu Yiyi Liu Ying Wang Ying Wang Qing Wu Qing Wu Qing Wu Prevalence and risk factors of metabolic associated fatty liver disease in lean patients with bipolar disorder: a retrospective cross-sectional study Frontiers in Endocrinology bipolar disorder MAFLD lean type prevalence risk factors |
| title | Prevalence and risk factors of metabolic associated fatty liver disease in lean patients with bipolar disorder: a retrospective cross-sectional study |
| title_full | Prevalence and risk factors of metabolic associated fatty liver disease in lean patients with bipolar disorder: a retrospective cross-sectional study |
| title_fullStr | Prevalence and risk factors of metabolic associated fatty liver disease in lean patients with bipolar disorder: a retrospective cross-sectional study |
| title_full_unstemmed | Prevalence and risk factors of metabolic associated fatty liver disease in lean patients with bipolar disorder: a retrospective cross-sectional study |
| title_short | Prevalence and risk factors of metabolic associated fatty liver disease in lean patients with bipolar disorder: a retrospective cross-sectional study |
| title_sort | prevalence and risk factors of metabolic associated fatty liver disease in lean patients with bipolar disorder a retrospective cross sectional study |
| topic | bipolar disorder MAFLD lean type prevalence risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1605484/full |
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