Interplay of heavy chain introns influences efficient transcript splicing and affects product quality of recombinant biotherapeutic antibodies from CHO cells
Introns are included in genes encoding therapeutic proteins for their well-documented function of boosting expression. However, mis-splicing of introns in recombinant immunoglobulin (IgG) heavy chain (HC) transcripts can produce amino acid sequence product variants. These variants can affect product...
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| Main Authors: | , , , , , |
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| פורמט: | Article |
| שפה: | אנגלית |
| יצא לאור: |
Taylor & Francis Group
2023-12-01
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| סדרה: | mAbs |
| נושאים: | |
| גישה מקוונת: | https://www.tandfonline.com/doi/10.1080/19420862.2023.2242548 |
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