Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase F

Upregulated Hexokinase-2 in Airway Epithelium Regulates Apoptosis and Drives Inflammation in Asthma via Peptidylprolyl Isomerase F

Hexokinase catalyzes the first rate-limiting step glycolysis. However, the roles of hexokinase 2 (HK2) in asthma remain incompletely understood. This study aimed to investigate metabolic alterations in asthma, focusing on the expression, function and regulation of HK2. In this study, non-targeted me...

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Bibliographic Details
Main Authors: Zhen Tian, Hongyan Zheng, Yan Fan, Boyu Li, Zhenli Huang, Meijia Wang, Jixian Zhang, Jianping Zhao, Shanshan Wang, Jungang Xie
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
asthma
hexokinase 2
glycolysis
airway inflammation
apoptosis
Online Access:https://www.mdpi.com/2073-4409/14/13/1004
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