Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral Uveitis
The article presents clinical observation of the patient at the age of 7 years suffering from severe juvenile idiopathic arthritis with uveitis refractory to standard antirheumatic therapy. The case complexity was determined by multiple joint damages, presence of bilateral uveitis, and hyperimmunogl...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2016-08-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/1644 |
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| author | Lelia A. Galstian Elena S. Zholobova Alexandra V. Starikova Ekaterina V. Denisova |
| author_facet | Lelia A. Galstian Elena S. Zholobova Alexandra V. Starikova Ekaterina V. Denisova |
| author_sort | Lelia A. Galstian |
| collection | DOAJ |
| description | The article presents clinical observation of the patient at the age of 7 years suffering from severe juvenile idiopathic arthritis with uveitis refractory to standard antirheumatic therapy. The case complexity was determined by multiple joint damages, presence of bilateral uveitis, and hyperimmunoglobulinemia at the disease onset. The successful use of abatacept is described: remission from both the articular syndrome and uveitis, a 100% improvement by ACRpedi criteria are reached. The selection of a biological preparation was determined by a polyarticular joint disease, by the presence of active recurrent uveitis, as well as by immune status compromise for TB infection. A gradual increase in abatacept efficacy and remission maintenance for a long time period are demonstrated. |
| format | Article |
| id | doaj-art-aadcde36e8524cb3b14e436be6ff817c |
| institution | Matheson Library |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-aadcde36e8524cb3b14e436be6ff817c2025-08-04T13:09:38Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352016-08-0115330731010.15690/vsp.v15i3.15691606Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral UveitisLelia A. Galstian0Elena S. Zholobova1Alexandra V. Starikova2Ekaterina V. Denisova3Children’s Clinical University Hospital of I.M. Sechenov First Moscow State Medical University, Moscow, Russian FederationChildren’s Clinical University Hospital of I.M. Sechenov First Moscow State Medical University, Moscow, Russian FederationMoscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian FederationMoscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian FederationThe article presents clinical observation of the patient at the age of 7 years suffering from severe juvenile idiopathic arthritis with uveitis refractory to standard antirheumatic therapy. The case complexity was determined by multiple joint damages, presence of bilateral uveitis, and hyperimmunoglobulinemia at the disease onset. The successful use of abatacept is described: remission from both the articular syndrome and uveitis, a 100% improvement by ACRpedi criteria are reached. The selection of a biological preparation was determined by a polyarticular joint disease, by the presence of active recurrent uveitis, as well as by immune status compromise for TB infection. A gradual increase in abatacept efficacy and remission maintenance for a long time period are demonstrated.https://vsp.spr-journal.ru/jour/article/view/1644childrenjuvenile idiopathic arthritisuveitisabatacept |
| spellingShingle | Lelia A. Galstian Elena S. Zholobova Alexandra V. Starikova Ekaterina V. Denisova Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral Uveitis Вопросы современной педиатрии children juvenile idiopathic arthritis uveitis abatacept |
| title | Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral Uveitis |
| title_full | Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral Uveitis |
| title_fullStr | Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral Uveitis |
| title_full_unstemmed | Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral Uveitis |
| title_short | Efficacy of Abatacept Therapy in a Patient with Juvenile Idiopathic Arthritis and Bilateral Uveitis |
| title_sort | efficacy of abatacept therapy in a patient with juvenile idiopathic arthritis and bilateral uveitis |
| topic | children juvenile idiopathic arthritis uveitis abatacept |
| url | https://vsp.spr-journal.ru/jour/article/view/1644 |
| work_keys_str_mv | AT leliaagalstian efficacyofabatacepttherapyinapatientwithjuvenileidiopathicarthritisandbilateraluveitis AT elenaszholobova efficacyofabatacepttherapyinapatientwithjuvenileidiopathicarthritisandbilateraluveitis AT alexandravstarikova efficacyofabatacepttherapyinapatientwithjuvenileidiopathicarthritisandbilateraluveitis AT ekaterinavdenisova efficacyofabatacepttherapyinapatientwithjuvenileidiopathicarthritisandbilateraluveitis |