Exploring the Role of Exosomes in Accelerating Orthodontic Tooth Movement
Background: Alveolar bone remodeling is a complicated biological process that is involved in orthodontic tooth movement (OTM). Recent studies have shown how exosomes, which are cell-secreted nanovesicles, influence cellular communication and encourage bone remodeling. Materials and Methods: Twenty W...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_82_25 |
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| author | Abdalwhab Zwiri Mohammad Khursheed Alam Mohammad Younis Hajeer Ebtehal Dhyab M. Alserhani Dalia Abdulrahman Alanazi Jinan Mohammed Alanazi Nor Farid Bin Mohd Noor Zafrina Islam |
| author_facet | Abdalwhab Zwiri Mohammad Khursheed Alam Mohammad Younis Hajeer Ebtehal Dhyab M. Alserhani Dalia Abdulrahman Alanazi Jinan Mohammed Alanazi Nor Farid Bin Mohd Noor Zafrina Islam |
| author_sort | Abdalwhab Zwiri |
| collection | DOAJ |
| description | Background:
Alveolar bone remodeling is a complicated biological process that is involved in orthodontic tooth movement (OTM). Recent studies have shown how exosomes, which are cell-secreted nanovesicles, influence cellular communication and encourage bone remodeling.
Materials and Methods:
Twenty Wistar rats were used in a prospective experimental investigation and split into two groups: one received exosome-enriched medium as an experimental treatment, and the other was a control group. The maxillary first molars were subjected to 10 g of force for 21 days to induce orthodontic tooth movement. The control group was given saline, whereas the experimental group was given injections of exosome-enriched media around the periodontal ligament every two weeks. Bone remodeling and root resorption were measured using histological examination and micro-CT analysis. ELISA and TRAP staining were used to measure arbitrary indicators of osteoclast activity and inflammation, respectively.
Results:
The OTM distance of the experimental group was significantly greater (1.5 ± 0.2 mm) than that of the control group (0.9 ± 0.1 mm; P < 0.05). The experimental group had 30% more osteoclasts, indicating increased alveolar bone resorption, according to micro-CT analysis. Histological analysis revealed that the group treated with exosomes had less inflammation and root resorption. Furthermore, ELISA verified that the experimental group had lower OPG levels and higher RANKL levels, suggesting faster bone remodeling.
Conclusion:
By encouraging alveolar bone remodeling and lowering inflammation, exosomes greatly improve orthodontic tooth mobility. According to these results, exosome-based treatments may be a viable additional treatment option to improve clinical results and hasten orthodontic tooth movement. |
| format | Article |
| id | doaj-art-a9d2d020328c4f32bbc7d657519e53d2 |
| institution | Matheson Library |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-a9d2d020328c4f32bbc7d657519e53d22025-07-05T11:19:55ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1267S126910.4103/jpbs.jpbs_82_25Exploring the Role of Exosomes in Accelerating Orthodontic Tooth MovementAbdalwhab ZwiriMohammad Khursheed AlamMohammad Younis HajeerEbtehal Dhyab M. AlserhaniDalia Abdulrahman AlanaziJinan Mohammed AlanaziNor Farid Bin Mohd NoorZafrina IslamBackground: Alveolar bone remodeling is a complicated biological process that is involved in orthodontic tooth movement (OTM). Recent studies have shown how exosomes, which are cell-secreted nanovesicles, influence cellular communication and encourage bone remodeling. Materials and Methods: Twenty Wistar rats were used in a prospective experimental investigation and split into two groups: one received exosome-enriched medium as an experimental treatment, and the other was a control group. The maxillary first molars were subjected to 10 g of force for 21 days to induce orthodontic tooth movement. The control group was given saline, whereas the experimental group was given injections of exosome-enriched media around the periodontal ligament every two weeks. Bone remodeling and root resorption were measured using histological examination and micro-CT analysis. ELISA and TRAP staining were used to measure arbitrary indicators of osteoclast activity and inflammation, respectively. Results: The OTM distance of the experimental group was significantly greater (1.5 ± 0.2 mm) than that of the control group (0.9 ± 0.1 mm; P < 0.05). The experimental group had 30% more osteoclasts, indicating increased alveolar bone resorption, according to micro-CT analysis. Histological analysis revealed that the group treated with exosomes had less inflammation and root resorption. Furthermore, ELISA verified that the experimental group had lower OPG levels and higher RANKL levels, suggesting faster bone remodeling. Conclusion: By encouraging alveolar bone remodeling and lowering inflammation, exosomes greatly improve orthodontic tooth mobility. According to these results, exosome-based treatments may be a viable additional treatment option to improve clinical results and hasten orthodontic tooth movement.https://journals.lww.com/10.4103/jpbs.jpbs_82_25alveolar bone resorptionbone remodelingcellular communicationexosomesorthodontic tooth movementrankl |
| spellingShingle | Abdalwhab Zwiri Mohammad Khursheed Alam Mohammad Younis Hajeer Ebtehal Dhyab M. Alserhani Dalia Abdulrahman Alanazi Jinan Mohammed Alanazi Nor Farid Bin Mohd Noor Zafrina Islam Exploring the Role of Exosomes in Accelerating Orthodontic Tooth Movement Journal of Pharmacy and Bioallied Sciences alveolar bone resorption bone remodeling cellular communication exosomes orthodontic tooth movement rankl |
| title | Exploring the Role of Exosomes in Accelerating Orthodontic Tooth Movement |
| title_full | Exploring the Role of Exosomes in Accelerating Orthodontic Tooth Movement |
| title_fullStr | Exploring the Role of Exosomes in Accelerating Orthodontic Tooth Movement |
| title_full_unstemmed | Exploring the Role of Exosomes in Accelerating Orthodontic Tooth Movement |
| title_short | Exploring the Role of Exosomes in Accelerating Orthodontic Tooth Movement |
| title_sort | exploring the role of exosomes in accelerating orthodontic tooth movement |
| topic | alveolar bone resorption bone remodeling cellular communication exosomes orthodontic tooth movement rankl |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_82_25 |
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