Regulatory effects of Xihu Longjing tea on the intestinal flora of mice fed with high-fat and high-fructose diet
An increasing number of studies have shown that the intestinal flora and microbial ecology mediated by the intestinal flora play key roles in metabolic disorders associated with high-fat and high-fructose diet. In this study, we investigated the effects of Xihu Longjing tea on the intestinal flora o...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhejiang University Press
2024-06-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
| Subjects: | |
| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2023.03.163 |
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| Summary: | An increasing number of studies have shown that the intestinal flora and microbial ecology mediated by the intestinal flora play key roles in metabolic disorders associated with high-fat and high-fructose diet. In this study, we investigated the effects of Xihu Longjing tea on the intestinal flora of mice fed with a conventional diet, followed by the construction of a mouse model with a high-fat and high-fructose diet to investigate the effects of Xihu Longjing on the prevention of lipid accumulation, intestinal barrier function impairment and intestinal microecological disorders in mice fed with high-fat and high-fructose diet. The results showed that Xihu Longjing tea soup inhibited the body mass gain and lipid accumulation in mice fed with a high-fat and high-fructose diet and effectively relieved metabolic disorders. When investigating the protective effects of Xihu Longjing on intestinal homeostasis in mice fed with a high-fat and high-fructose diet, it was found that Xihu Longjing tea soup treatment inhibited the expression of hypoxia inducible factor-1α (HIF-1α) and its target genes enolase-1 (ENO1)<italic/>and<italic/>lactate dehydrogenase A (LDHA) in the intestinal epithelial cells of mice. In addition, Xihu Longjing tea soup intervention reduced the abundance of intestinal bacteria of Firmicutes/Bacteroidota ratio and enriched the abundance of probiotic bacteria such as norank_f_Muribaculaceae<italic/>in mice, and then the high-fat and high-fructose diet with low concentration of Xihu Longjing treatment enriched Lachnospiraceae bacteria and the high-fat and high-fructose diet with high concentration of Xihu Longjing treatment increased the relative abundance of Oscillospirales bacteria. The results provide a theoretical basis for Longjing tea to regulate fat accumulation by improving intestinal flora disorders, and provide theoretical support for the ability of tea consumption to improve intestinal health and play a role in fat reduction and body mass loss. |
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| ISSN: | 1008-9209 2097-5155 |