Transposon-directed insertion-site sequencing (TraDIS) analysis of Enterococcus faecium using nanopore sequencing and a WebAssembly analysis platform

Transposon-directed insertion-site sequencing (TraDIS) analysis of Enterococcus faecium using nanopore sequencing and a WebAssembly analysis platform

ABSTRACT Vancomycin-resistant Enterococcus faecium (VREfm) are healthcare-associated opportunistic pathogens of global significance. Genetic tools are needed to understand the molecular basis for VREfm clinically relevant phenotypes, such as persistence within the human gut or antimicrobial resistan...

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Main Authors: Alexandra L. Krause, Wytamma Wirth, Adrianna M. Turner, Louise Judd, Lucy Li, Willem van Schaik, Benjamin P. Howden, Glen P. Carter, Torsten Seemann, Ryan Wick, Timothy P. Stinear, Andrew H. Buultjens, Ian R. Monk
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
transposons
DNA sequencing
Enterococcus faecium
TraDIS
fitness
vancomycin resistance
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00628-25
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