A retrospective comparative study of microwave ablation and sublobectomy in the treatment of early subpleural nonsmall cell lung cancer
Objective Microwave ablation (MWA) is a safe and effective local therapy, however, its efficacy in stage I subpleural nonsmall cell lung cancer (NSCLC) compared to that of sublobar resection (SLR) is unclear. This study aimed to compare the efficacy of the two treatments for stage I NSCLC ≤1 cm from...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2022.2136410 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839622824845639680 |
|---|---|
| author | Jianwei Liu Caixia Wang Weiwei Yi Hang Zheng Aimin Zheng |
| author_facet | Jianwei Liu Caixia Wang Weiwei Yi Hang Zheng Aimin Zheng |
| author_sort | Jianwei Liu |
| collection | DOAJ |
| description | Objective Microwave ablation (MWA) is a safe and effective local therapy, however, its efficacy in stage I subpleural nonsmall cell lung cancer (NSCLC) compared to that of sublobar resection (SLR) is unclear. This study aimed to compare the efficacy of the two treatments for stage I NSCLC ≤1 cm from the pleura.Methods After propensity score matching (PSM), 70 patients with stage I subpleural NSCLC who underwent either SLR or MWA (35 patients each) from 2014 to 2018 were included. The margin pathology of SLR was negative. MWA reached a sufficient ablative margin. MWA group were stratified according to the minimal ablative margin, with 10 patients each in the 5–10 mm group and the >10 mm group after PSM. The local recurrence-free survival (LRFS), relapse-free survival (RFS), overall survival (OS), and treatment-related complications were compared.Results For patients with stage I subpleural NSCLC, the LRFS of patients in the SLR group (35.657 ± 0.338 months, 95% CI: 34.995–36.319) was significantly better than that in the MWA group (31.633 ± 1.574 months, 95% CI: 28.548–34.719, p = 0.021). The RFS was also significantly better in the SLR group (35.629 ± 0.338 months, 95% CI: 34.966–36.292) than in the MWA group (29.387 ± 1.866 months, 95% CI: 25.730–33.044, p = 0.007), but there were no significant differences in terms of the 3-year OS (p = 0.079) and incidence of complications (14.3% vs. 11.4%, p = 0.653). The minimal ablative margin of >10 mm was not significantly associated with the LRFS (p = 0.929).Conclusion MWA for stage I subpleural NSCLC showed similar survival outcomes and complication rates to SLR, but poorer local tumor control. |
| format | Article |
| id | doaj-art-a941b51d18ee42cea1b701f83f03bc72 |
| institution | Matheson Library |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-a941b51d18ee42cea1b701f83f03bc722025-07-21T16:18:22ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572022-12-013911379138610.1080/02656736.2022.2136410A retrospective comparative study of microwave ablation and sublobectomy in the treatment of early subpleural nonsmall cell lung cancerJianwei Liu0Caixia Wang1Weiwei Yi2Hang Zheng3Aimin Zheng4Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, ChinaDepartment of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaObjective Microwave ablation (MWA) is a safe and effective local therapy, however, its efficacy in stage I subpleural nonsmall cell lung cancer (NSCLC) compared to that of sublobar resection (SLR) is unclear. This study aimed to compare the efficacy of the two treatments for stage I NSCLC ≤1 cm from the pleura.Methods After propensity score matching (PSM), 70 patients with stage I subpleural NSCLC who underwent either SLR or MWA (35 patients each) from 2014 to 2018 were included. The margin pathology of SLR was negative. MWA reached a sufficient ablative margin. MWA group were stratified according to the minimal ablative margin, with 10 patients each in the 5–10 mm group and the >10 mm group after PSM. The local recurrence-free survival (LRFS), relapse-free survival (RFS), overall survival (OS), and treatment-related complications were compared.Results For patients with stage I subpleural NSCLC, the LRFS of patients in the SLR group (35.657 ± 0.338 months, 95% CI: 34.995–36.319) was significantly better than that in the MWA group (31.633 ± 1.574 months, 95% CI: 28.548–34.719, p = 0.021). The RFS was also significantly better in the SLR group (35.629 ± 0.338 months, 95% CI: 34.966–36.292) than in the MWA group (29.387 ± 1.866 months, 95% CI: 25.730–33.044, p = 0.007), but there were no significant differences in terms of the 3-year OS (p = 0.079) and incidence of complications (14.3% vs. 11.4%, p = 0.653). The minimal ablative margin of >10 mm was not significantly associated with the LRFS (p = 0.929).Conclusion MWA for stage I subpleural NSCLC showed similar survival outcomes and complication rates to SLR, but poorer local tumor control.https://www.tandfonline.com/doi/10.1080/02656736.2022.2136410Early subpleural lung tumorssublobar resectionmicrowave ablationlocal recurrencesurvival |
| spellingShingle | Jianwei Liu Caixia Wang Weiwei Yi Hang Zheng Aimin Zheng A retrospective comparative study of microwave ablation and sublobectomy in the treatment of early subpleural nonsmall cell lung cancer International Journal of Hyperthermia Early subpleural lung tumors sublobar resection microwave ablation local recurrence survival |
| title | A retrospective comparative study of microwave ablation and sublobectomy in the treatment of early subpleural nonsmall cell lung cancer |
| title_full | A retrospective comparative study of microwave ablation and sublobectomy in the treatment of early subpleural nonsmall cell lung cancer |
| title_fullStr | A retrospective comparative study of microwave ablation and sublobectomy in the treatment of early subpleural nonsmall cell lung cancer |
| title_full_unstemmed | A retrospective comparative study of microwave ablation and sublobectomy in the treatment of early subpleural nonsmall cell lung cancer |
| title_short | A retrospective comparative study of microwave ablation and sublobectomy in the treatment of early subpleural nonsmall cell lung cancer |
| title_sort | retrospective comparative study of microwave ablation and sublobectomy in the treatment of early subpleural nonsmall cell lung cancer |
| topic | Early subpleural lung tumors sublobar resection microwave ablation local recurrence survival |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2022.2136410 |
| work_keys_str_mv | AT jianweiliu aretrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer AT caixiawang aretrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer AT weiweiyi aretrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer AT hangzheng aretrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer AT aiminzheng aretrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer AT jianweiliu retrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer AT caixiawang retrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer AT weiweiyi retrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer AT hangzheng retrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer AT aiminzheng retrospectivecomparativestudyofmicrowaveablationandsublobectomyinthetreatmentofearlysubpleuralnonsmallcelllungcancer |