TARGET LEVELS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM COMPONENTS AND THEIR ROLE IN CARDIOVASCULAR EVENT DEVELOPMENT AMONG PATIENTS WITH ARTERIAL HYPERTENSION
The aim of this study was to identify the optimal, characterised by minimal risk of cardiovascular events (CVE), levels of renin-angiotensin-aldosterone system (RAAS) components in patients with arterial hypertension (AH). In total, 454 patients with high-risk AH were examined (age 18-65 years; 92 m...
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«FIRMA «SILICEA» LLC
2009-06-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1350 |
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| author | Sh. V. Akhadov G. R. Ruzbanova G. S. Molchanova T. G. Talalaeva S. N. Khoreva |
| author_facet | Sh. V. Akhadov G. R. Ruzbanova G. S. Molchanova T. G. Talalaeva S. N. Khoreva |
| author_sort | Sh. V. Akhadov |
| collection | DOAJ |
| description | The aim of this study was to identify the optimal, characterised by minimal risk of cardiovascular events (CVE), levels of renin-angiotensin-aldosterone system (RAAS) components in patients with arterial hypertension (AH). In total, 454 patients with high-risk AH were examined (age 18-65 years; 92 men, 362 women). Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were assessed by radio-immune method, adrenalin and noradrenalin concentration in 24-hour urine sample – by fluorometric method, left ventricular myocardial structure and function – by echocardiography, renal function – by glomerular filtration rate (Reberg method) and 123 I-Hippuran renography. Target levels of RAAS components were defined as follows: PRA=0,22-3,0 ng/ml/h, if PAC: PRA=5-23 and PAC=0,18- 0,83 nmol/l (5-23 ng/dl). In patients with high CVE risk, the target levels of PRA=0,22-1,0 ng/ml/h and PAC: PRA=5-23 would minimize the risk of stroke, myocardial infarction, and target organ damage. |
| format | Article |
| id | doaj-art-a9234ae62d9f44d78553aebf7f4efb51 |
| institution | Matheson Library |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2009-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-a9234ae62d9f44d78553aebf7f4efb512025-08-04T13:00:03Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202009-06-010326321139TARGET LEVELS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM COMPONENTS AND THEIR ROLE IN CARDIOVASCULAR EVENT DEVELOPMENT AMONG PATIENTS WITH ARTERIAL HYPERTENSIONSh. V. Akhadov0G. R. Ruzbanova1G. S. Molchanova2T. G. Talalaeva3S. N. Khoreva4Городская поликлиника №81 САОГородская поликлиника №81 САОМосковский областной научно-исследовательский клинический институт им. М.Ф.Владимирского, МоскваМосковский областной научно-исследовательский клинический институт им. М.Ф.Владимирского, МоскваМосковский областной научно-исследовательский клинический институт им. М.Ф.Владимирского, МоскваThe aim of this study was to identify the optimal, characterised by minimal risk of cardiovascular events (CVE), levels of renin-angiotensin-aldosterone system (RAAS) components in patients with arterial hypertension (AH). In total, 454 patients with high-risk AH were examined (age 18-65 years; 92 men, 362 women). Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were assessed by radio-immune method, adrenalin and noradrenalin concentration in 24-hour urine sample – by fluorometric method, left ventricular myocardial structure and function – by echocardiography, renal function – by glomerular filtration rate (Reberg method) and 123 I-Hippuran renography. Target levels of RAAS components were defined as follows: PRA=0,22-3,0 ng/ml/h, if PAC: PRA=5-23 and PAC=0,18- 0,83 nmol/l (5-23 ng/dl). In patients with high CVE risk, the target levels of PRA=0,22-1,0 ng/ml/h and PAC: PRA=5-23 would minimize the risk of stroke, myocardial infarction, and target organ damage.https://russjcardiol.elpub.ru/jour/article/view/1350arterial hypertensionplasma renin activityplasma aldosterone concentrationmyocardial infarctionstroke |
| spellingShingle | Sh. V. Akhadov G. R. Ruzbanova G. S. Molchanova T. G. Talalaeva S. N. Khoreva TARGET LEVELS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM COMPONENTS AND THEIR ROLE IN CARDIOVASCULAR EVENT DEVELOPMENT AMONG PATIENTS WITH ARTERIAL HYPERTENSION Российский кардиологический журнал arterial hypertension plasma renin activity plasma aldosterone concentration myocardial infarction stroke |
| title | TARGET LEVELS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM COMPONENTS AND THEIR ROLE IN CARDIOVASCULAR EVENT DEVELOPMENT AMONG PATIENTS WITH ARTERIAL HYPERTENSION |
| title_full | TARGET LEVELS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM COMPONENTS AND THEIR ROLE IN CARDIOVASCULAR EVENT DEVELOPMENT AMONG PATIENTS WITH ARTERIAL HYPERTENSION |
| title_fullStr | TARGET LEVELS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM COMPONENTS AND THEIR ROLE IN CARDIOVASCULAR EVENT DEVELOPMENT AMONG PATIENTS WITH ARTERIAL HYPERTENSION |
| title_full_unstemmed | TARGET LEVELS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM COMPONENTS AND THEIR ROLE IN CARDIOVASCULAR EVENT DEVELOPMENT AMONG PATIENTS WITH ARTERIAL HYPERTENSION |
| title_short | TARGET LEVELS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM COMPONENTS AND THEIR ROLE IN CARDIOVASCULAR EVENT DEVELOPMENT AMONG PATIENTS WITH ARTERIAL HYPERTENSION |
| title_sort | target levels of renin angiotensin aldosterone system components and their role in cardiovascular event development among patients with arterial hypertension |
| topic | arterial hypertension plasma renin activity plasma aldosterone concentration myocardial infarction stroke |
| url | https://russjcardiol.elpub.ru/jour/article/view/1350 |
| work_keys_str_mv | AT shvakhadov targetlevelsofreninangiotensinaldosteronesystemcomponentsandtheirroleincardiovasculareventdevelopmentamongpatientswitharterialhypertension AT grruzbanova targetlevelsofreninangiotensinaldosteronesystemcomponentsandtheirroleincardiovasculareventdevelopmentamongpatientswitharterialhypertension AT gsmolchanova targetlevelsofreninangiotensinaldosteronesystemcomponentsandtheirroleincardiovasculareventdevelopmentamongpatientswitharterialhypertension AT tgtalalaeva targetlevelsofreninangiotensinaldosteronesystemcomponentsandtheirroleincardiovasculareventdevelopmentamongpatientswitharterialhypertension AT snkhoreva targetlevelsofreninangiotensinaldosteronesystemcomponentsandtheirroleincardiovasculareventdevelopmentamongpatientswitharterialhypertension |