Evaluation The role of Trefoil Factor1 as early stage biomarker in patients with Nephrolithiasis
Nephrolithiasis is a public health problem that affect large scale of peoples around the world. naturally, there are many substances ,proteins, lipids, glycosaminoglycans and inorganic compounds, work as kidney stone inhibitors in the normal renal tubular fluid that inhibit crystal growth, aggregat...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Tikrit University
2023-01-01
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| Series: | Tikrit Journal of Pure Science |
| Subjects: | |
| Online Access: | https://tjpsj.org/index.php/tjps/article/view/807 |
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| Summary: | Nephrolithiasis is a public health problem that affect large scale of
peoples around the world. naturally, there are many substances ,proteins,
lipids, glycosaminoglycans and inorganic compounds, work as kidney
stone inhibitors in the normal renal tubular fluid that inhibit crystal
growth, aggregation, and/or adhesion to renal surfaces, among this
inhibitors we investigate the concentration of trefoil factor 1 (TFF1) as a
stone formation inhibitor and kidney injury biomarker in serum of 75
kidney stone patients and 15 healthy subjects using ELISA technique.
The results shows no significant changes within patients groups while
shows that TFF1 levels were significantly increased in stone patients
when compared with the healthy controls (P≤0.05), which support the
fact that it could use as early marker of kidney injury (KI) .The results
also revealed no significant changes within patients groups while there
was a significant changes between patients and controls for both blood
urea and serum creatinine levels in renal stone patients in comparison to
the apparently healthy control subjects (P ≤0.05). Further investigation
are needed to show the inhibitory effect of TFF1 in urine of kidney stone
patients.
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| ISSN: | 1813-1662 2415-1726 |