Co-Induction of ULK-1 and AHSP mRNAs in Erythroid Precursor Cells Isolated From a Sirolimus-Treated β-Thalassemia Patient: A Case Report Study

Co-Induction of ULK-1 and AHSP mRNAs in Erythroid Precursor Cells Isolated From a Sirolimus-Treated β-Thalassemia Patient: A Case Report Study

IntroductionThe β-thalassemias are inherited genetic disorders affecting the hematopoietic system and caused by mutations of the adult β-globin gene, leading to low or absent production of adult hemoglobin. In addition, an excess of free α-globin is associated with ineffective erythropoiesis. In fac...

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Bibliographic Details
Main Authors: Matteo Zurlo, Alessia Finotti, Maria Rita Gamberini, Roberto Gambari
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:British Journal of Biomedical Science
Subjects:
β-thalassemia
sirolimus
autophagy
Ulk-1
AHSP
Online Access:https://www.frontierspartnerships.org/articles/10.3389/bjbs.2025.14311/full
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