Efficient Synthesis of Substituted 2-Nitrochalcone Derivatives
Organic synthesis plays a fundamental role in medicinal chemistry, allowing the production of compounds with desirable pharmacological properties. In this context, new synthesis methods, such as the use of ultrasound, are continuously being explored to improve the efficiency and sustainability of th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Chemistry Proceedings |
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| Online Access: | https://www.mdpi.com/2673-4583/16/1/85 |
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| author | Alam Yair Hidalgo Quirino Torres-Sauret Carlos Ernesto Lobato-García Miguel Ángel Vilchis-Reyes Abraham Gómez-Rivera Oswaldo Hernandez-Abreu Nancy Romero-Ceronio |
| author_facet | Alam Yair Hidalgo Quirino Torres-Sauret Carlos Ernesto Lobato-García Miguel Ángel Vilchis-Reyes Abraham Gómez-Rivera Oswaldo Hernandez-Abreu Nancy Romero-Ceronio |
| author_sort | Alam Yair Hidalgo |
| collection | DOAJ |
| description | Organic synthesis plays a fundamental role in medicinal chemistry, allowing the production of compounds with desirable pharmacological properties. In this context, new synthesis methods, such as the use of ultrasound, are continuously being explored to improve the efficiency and sustainability of these processes. In this work, the synthesis and structural characterization of 2-nitrochalcone derivatives substituted with electron-withdrawing (fluoro) and electron-donating (methoxy) groups in the three isomeric positions of the B ring via nuclear magnetic resonance and ultrasound are presented; both a conventional method and a nonconventional ultrasound-assisted method are used. The results show that both methodologies are effective for obtaining these compounds, but the conventional method presents some additional advantages in the case of these nitrochalcones, such as shorter reaction times and better reaction yields. |
| format | Article |
| id | doaj-art-a8a8370a2e4b400f9f6af3336c26e48b |
| institution | Matheson Library |
| issn | 2673-4583 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry Proceedings |
| spelling | doaj-art-a8a8370a2e4b400f9f6af3336c26e48b2025-06-25T13:37:50ZengMDPI AGChemistry Proceedings2673-45832024-11-011618510.3390/ecsoc-28-20109Efficient Synthesis of Substituted 2-Nitrochalcone DerivativesAlam Yair Hidalgo0Quirino Torres-Sauret1Carlos Ernesto Lobato-García2Miguel Ángel Vilchis-Reyes3Abraham Gómez-Rivera4Oswaldo Hernandez-Abreu5Nancy Romero-Ceronio6División Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa km 1, Col. La Esperanza, Cunduacán 86690, Tabasco, MexicoDivisión Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa km 1, Col. La Esperanza, Cunduacán 86690, Tabasco, MexicoDivisión Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa km 1, Col. La Esperanza, Cunduacán 86690, Tabasco, MexicoDivisión Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa km 1, Col. La Esperanza, Cunduacán 86690, Tabasco, MexicoDivisión Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa km 1, Col. La Esperanza, Cunduacán 86690, Tabasco, MexicoDivisión Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa km 1, Col. La Esperanza, Cunduacán 86690, Tabasco, MexicoDivisión Académica de Ciencias Básicas, Universidad Juárez Autónoma de Tabasco, Carretera Cunduacán-Jalpa km 1, Col. La Esperanza, Cunduacán 86690, Tabasco, MexicoOrganic synthesis plays a fundamental role in medicinal chemistry, allowing the production of compounds with desirable pharmacological properties. In this context, new synthesis methods, such as the use of ultrasound, are continuously being explored to improve the efficiency and sustainability of these processes. In this work, the synthesis and structural characterization of 2-nitrochalcone derivatives substituted with electron-withdrawing (fluoro) and electron-donating (methoxy) groups in the three isomeric positions of the B ring via nuclear magnetic resonance and ultrasound are presented; both a conventional method and a nonconventional ultrasound-assisted method are used. The results show that both methodologies are effective for obtaining these compounds, but the conventional method presents some additional advantages in the case of these nitrochalcones, such as shorter reaction times and better reaction yields.https://www.mdpi.com/2673-4583/16/1/85synthesisultrasound2-nitrochalcones |
| spellingShingle | Alam Yair Hidalgo Quirino Torres-Sauret Carlos Ernesto Lobato-García Miguel Ángel Vilchis-Reyes Abraham Gómez-Rivera Oswaldo Hernandez-Abreu Nancy Romero-Ceronio Efficient Synthesis of Substituted 2-Nitrochalcone Derivatives Chemistry Proceedings synthesis ultrasound 2-nitrochalcones |
| title | Efficient Synthesis of Substituted 2-Nitrochalcone Derivatives |
| title_full | Efficient Synthesis of Substituted 2-Nitrochalcone Derivatives |
| title_fullStr | Efficient Synthesis of Substituted 2-Nitrochalcone Derivatives |
| title_full_unstemmed | Efficient Synthesis of Substituted 2-Nitrochalcone Derivatives |
| title_short | Efficient Synthesis of Substituted 2-Nitrochalcone Derivatives |
| title_sort | efficient synthesis of substituted 2 nitrochalcone derivatives |
| topic | synthesis ultrasound 2-nitrochalcones |
| url | https://www.mdpi.com/2673-4583/16/1/85 |
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