Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment
Summary: Motivationally significant events, such as rewards and threats, modify neural representations of the environment where they occur. The medial prefrontal cortex (mPFC) forms map-like representations anchored to these events. Using miniscope calcium imaging, we investigated how unexpected thr...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225012702 |
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| author | Yangzi Chen Gaqi Tu Lizhe Zhang Kaori Takehara-Nishiuchi |
| author_facet | Yangzi Chen Gaqi Tu Lizhe Zhang Kaori Takehara-Nishiuchi |
| author_sort | Yangzi Chen |
| collection | DOAJ |
| description | Summary: Motivationally significant events, such as rewards and threats, modify neural representations of the environment where they occur. The medial prefrontal cortex (mPFC) forms map-like representations anchored to these events. Using miniscope calcium imaging, we investigated how unexpected threats affected mPFC cell activity in mice, navigating a familiar path toward rewards. The introduction of threats increased the density of active cells near the threat location and triggered the emergence of a distinct population activity pattern that spanned the entire path. Notably, the difference between the new and original patterns was greater in the path segment leading to the new threats than in the segment leading to the existing rewards. This differentiation persisted during the subsequent learning of threat probabilities but ceased upon completion. Thus, event-induced remapping of mPFC population activity is scaled by the proximity to new events, enabling seamless integration of new events into the mental map of familiar environments. |
| format | Article |
| id | doaj-art-a8574e8cc6f8428bb890c38fedf0a94e |
| institution | Matheson Library |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-a8574e8cc6f8428bb890c38fedf0a94e2025-07-12T04:46:32ZengElsevieriScience2589-00422025-08-01288113009Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environmentYangzi Chen0Gaqi Tu1Lizhe Zhang2Kaori Takehara-Nishiuchi3Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Collaborative Program in Neuroscience, University of Toronto, Toronto, ON M5S 1A8, CanadaDepartment of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Collaborative Program in Neuroscience, University of Toronto, Toronto, ON M5S 1A8, CanadaDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, CanadaDepartment of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Collaborative Program in Neuroscience, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada; Corresponding authorSummary: Motivationally significant events, such as rewards and threats, modify neural representations of the environment where they occur. The medial prefrontal cortex (mPFC) forms map-like representations anchored to these events. Using miniscope calcium imaging, we investigated how unexpected threats affected mPFC cell activity in mice, navigating a familiar path toward rewards. The introduction of threats increased the density of active cells near the threat location and triggered the emergence of a distinct population activity pattern that spanned the entire path. Notably, the difference between the new and original patterns was greater in the path segment leading to the new threats than in the segment leading to the existing rewards. This differentiation persisted during the subsequent learning of threat probabilities but ceased upon completion. Thus, event-induced remapping of mPFC population activity is scaled by the proximity to new events, enabling seamless integration of new events into the mental map of familiar environments.http://www.sciencedirect.com/science/article/pii/S2589004225012702NeuroscienceSystems neuroscienceCognitive neuroscience |
| spellingShingle | Yangzi Chen Gaqi Tu Lizhe Zhang Kaori Takehara-Nishiuchi Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment iScience Neuroscience Systems neuroscience Cognitive neuroscience |
| title | Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment |
| title_full | Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment |
| title_fullStr | Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment |
| title_full_unstemmed | Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment |
| title_short | Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment |
| title_sort | graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment |
| topic | Neuroscience Systems neuroscience Cognitive neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225012702 |
| work_keys_str_mv | AT yangzichen gradedremappingofprefrontalrepresentationspreservesacumulativerecordofdistincteventswithinanenvironment AT gaqitu gradedremappingofprefrontalrepresentationspreservesacumulativerecordofdistincteventswithinanenvironment AT lizhezhang gradedremappingofprefrontalrepresentationspreservesacumulativerecordofdistincteventswithinanenvironment AT kaoritakeharanishiuchi gradedremappingofprefrontalrepresentationspreservesacumulativerecordofdistincteventswithinanenvironment |