Vaccination Reduces Fecal Shedding and Improves Carcass Quality in Pigs with Subclinical <i>Lawsonia intracellularis</i> Infections
<b>Background/Objectives</b>: <i>Lawsonia intracellularis</i> is a bacterium that causes Proliferative Enteropathy, an enteric infection characterized mainly by diarrhea and growth retardation, leading to important economic losses. Acute and chronic infections are easily diag...
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MDPI AG
2025-07-01
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| author | Rubén Del Pozo Sacristán Hanny Swam Stephan von Berg Amy Elizabeth Taylor |
| author_facet | Rubén Del Pozo Sacristán Hanny Swam Stephan von Berg Amy Elizabeth Taylor |
| author_sort | Rubén Del Pozo Sacristán |
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| description | <b>Background/Objectives</b>: <i>Lawsonia intracellularis</i> is a bacterium that causes Proliferative Enteropathy, an enteric infection characterized mainly by diarrhea and growth retardation, leading to important economic losses. Acute and chronic infections are easily diagnosed, and their control by vaccination has been proven efficacious. However, subclinical infections, despite being very prevalent, often remain underdiagnosed and uncontrolled in practice. Scarce research is available on the control of subclinical infections by vaccination, and the benefit in these scenarios remains to be elucidated. Two field trials were carried out to (1) determine the association between the growth and fecal shedding of <i>L. intracellularis</i> in unvaccinated and intramuscularly vaccinated pigs in a farm with subclinical infection and (2) assess the impact of intradermal vaccination against <i>L. intracellularis</i> on clinical performance and carcass quality in a herd with subclinical infection. <b>Methods</b>: A pig herd with subclinical infection was selected. Pigs were vaccinated intramuscularly (study 1) or intradermally (study 2) at weaning. Fecal shedding, performance, clinical parameters, and carcass quality were investigated. <b>Results</b>: Growth was negatively associated with the fecal load of <i>L. intracellularis</i> in non-vaccinated pigs, whereas in vaccinated pigs, growth performance was not impacted by fecal load (study 1). Vaccinated pigs presented a significantly lower fecal load, lower prevalence of tail biting (31.7%) compared with controls (54.2%), less back fat, and a greater Lean Meat percentage (study 2). <b>Conclusions</b>: Vaccination against <i>L. intracellularis</i> in a herd with subclinical infection and low fecal bacterial shedding led to a reduction in fecal shedding, a lower prevalence of tail biting, and an improvement in carcass quality. |
| format | Article |
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| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-a853f32945aa48a5a43e6d42375dcd262025-07-25T13:38:23ZengMDPI AGVaccines2076-393X2025-07-0113772810.3390/vaccines13070728Vaccination Reduces Fecal Shedding and Improves Carcass Quality in Pigs with Subclinical <i>Lawsonia intracellularis</i> InfectionsRubén Del Pozo Sacristán0Hanny Swam1Stephan von Berg2Amy Elizabeth Taylor3MSD Animal Health, Milton Keynes MK7 7AJ, UKMSD Animal Health, 5831 Boxmeer, The NetherlandsMSD Animal Health, 85716 Munich, GermanyNational Pig Centre, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK<b>Background/Objectives</b>: <i>Lawsonia intracellularis</i> is a bacterium that causes Proliferative Enteropathy, an enteric infection characterized mainly by diarrhea and growth retardation, leading to important economic losses. Acute and chronic infections are easily diagnosed, and their control by vaccination has been proven efficacious. However, subclinical infections, despite being very prevalent, often remain underdiagnosed and uncontrolled in practice. Scarce research is available on the control of subclinical infections by vaccination, and the benefit in these scenarios remains to be elucidated. Two field trials were carried out to (1) determine the association between the growth and fecal shedding of <i>L. intracellularis</i> in unvaccinated and intramuscularly vaccinated pigs in a farm with subclinical infection and (2) assess the impact of intradermal vaccination against <i>L. intracellularis</i> on clinical performance and carcass quality in a herd with subclinical infection. <b>Methods</b>: A pig herd with subclinical infection was selected. Pigs were vaccinated intramuscularly (study 1) or intradermally (study 2) at weaning. Fecal shedding, performance, clinical parameters, and carcass quality were investigated. <b>Results</b>: Growth was negatively associated with the fecal load of <i>L. intracellularis</i> in non-vaccinated pigs, whereas in vaccinated pigs, growth performance was not impacted by fecal load (study 1). Vaccinated pigs presented a significantly lower fecal load, lower prevalence of tail biting (31.7%) compared with controls (54.2%), less back fat, and a greater Lean Meat percentage (study 2). <b>Conclusions</b>: Vaccination against <i>L. intracellularis</i> in a herd with subclinical infection and low fecal bacterial shedding led to a reduction in fecal shedding, a lower prevalence of tail biting, and an improvement in carcass quality.https://www.mdpi.com/2076-393X/13/7/728<i>Lawsonia intracellularis</i>subclinical infectionsvaccinationfecal sheddinggrowthtail biting |
| spellingShingle | Rubén Del Pozo Sacristán Hanny Swam Stephan von Berg Amy Elizabeth Taylor Vaccination Reduces Fecal Shedding and Improves Carcass Quality in Pigs with Subclinical <i>Lawsonia intracellularis</i> Infections Vaccines <i>Lawsonia intracellularis</i> subclinical infections vaccination fecal shedding growth tail biting |
| title | Vaccination Reduces Fecal Shedding and Improves Carcass Quality in Pigs with Subclinical <i>Lawsonia intracellularis</i> Infections |
| title_full | Vaccination Reduces Fecal Shedding and Improves Carcass Quality in Pigs with Subclinical <i>Lawsonia intracellularis</i> Infections |
| title_fullStr | Vaccination Reduces Fecal Shedding and Improves Carcass Quality in Pigs with Subclinical <i>Lawsonia intracellularis</i> Infections |
| title_full_unstemmed | Vaccination Reduces Fecal Shedding and Improves Carcass Quality in Pigs with Subclinical <i>Lawsonia intracellularis</i> Infections |
| title_short | Vaccination Reduces Fecal Shedding and Improves Carcass Quality in Pigs with Subclinical <i>Lawsonia intracellularis</i> Infections |
| title_sort | vaccination reduces fecal shedding and improves carcass quality in pigs with subclinical i lawsonia intracellularis i infections |
| topic | <i>Lawsonia intracellularis</i> subclinical infections vaccination fecal shedding growth tail biting |
| url | https://www.mdpi.com/2076-393X/13/7/728 |
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