Microscopic polyangiitis: Modern concepts and treatment options
The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is v...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2021-10-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/3082 |
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| _version_ | 1839568248264196096 |
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| author | I. T. Murkamilov K. A. Aitbaev V. V. Fomin I. O. Kudaibergenova F. A. Yusupov Zh. A. Murkamilova T. V. Beketova |
| author_facet | I. T. Murkamilov K. A. Aitbaev V. V. Fomin I. O. Kudaibergenova F. A. Yusupov Zh. A. Murkamilova T. V. Beketova |
| author_sort | I. T. Murkamilov |
| collection | DOAJ |
| description | The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is very common and pulmonary capillaritis often occurs. MPA can cause rapidly progressive damage to organ systems. The modern possibilities of MPA treatment, primarily anti-B cell therapy with rituximab, are discussed. |
| format | Article |
| id | doaj-art-a8537db9be664b74a314f9935ebb51f7 |
| institution | Matheson Library |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2021-10-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-a8537db9be664b74a314f9935ebb51f72025-08-04T17:04:01ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922021-10-0159560861410.47360/1995-4484-2021-608-6142750Microscopic polyangiitis: Modern concepts and treatment optionsI. T. Murkamilov0K. A. Aitbaev1V. V. Fomin2I. O. Kudaibergenova3F. A. Yusupov4Zh. A. Murkamilova5T. V. Beketova6I.K. Akhunbaev Kyrgyz State Medical AcademyScientific and Research Institute of Molecular Biology and MedicineI.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)I.K. Akhunbaev Kyrgyz State Medical AcademyOsh State UniversityB.N. Yeltsin Kyrgyz-Russian Slavic UniversityV.A. Nasonova Research Institute of RheumatologyThe article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is very common and pulmonary capillaritis often occurs. MPA can cause rapidly progressive damage to organ systems. The modern possibilities of MPA treatment, primarily anti-B cell therapy with rituximab, are discussed.https://rsp.mediar-press.net/rsp/article/view/3082systemic vasculitisancamicroscopic polyangiitisglomerulonephritisalveolitismyeloperoxidaseproteinase 3glucocorticosteroidsrituximabcytostatics |
| spellingShingle | I. T. Murkamilov K. A. Aitbaev V. V. Fomin I. O. Kudaibergenova F. A. Yusupov Zh. A. Murkamilova T. V. Beketova Microscopic polyangiitis: Modern concepts and treatment options Научно-практическая ревматология systemic vasculitis anca microscopic polyangiitis glomerulonephritis alveolitis myeloperoxidase proteinase 3 glucocorticosteroids rituximab cytostatics |
| title | Microscopic polyangiitis: Modern concepts and treatment options |
| title_full | Microscopic polyangiitis: Modern concepts and treatment options |
| title_fullStr | Microscopic polyangiitis: Modern concepts and treatment options |
| title_full_unstemmed | Microscopic polyangiitis: Modern concepts and treatment options |
| title_short | Microscopic polyangiitis: Modern concepts and treatment options |
| title_sort | microscopic polyangiitis modern concepts and treatment options |
| topic | systemic vasculitis anca microscopic polyangiitis glomerulonephritis alveolitis myeloperoxidase proteinase 3 glucocorticosteroids rituximab cytostatics |
| url | https://rsp.mediar-press.net/rsp/article/view/3082 |
| work_keys_str_mv | AT itmurkamilov microscopicpolyangiitismodernconceptsandtreatmentoptions AT kaaitbaev microscopicpolyangiitismodernconceptsandtreatmentoptions AT vvfomin microscopicpolyangiitismodernconceptsandtreatmentoptions AT iokudaibergenova microscopicpolyangiitismodernconceptsandtreatmentoptions AT fayusupov microscopicpolyangiitismodernconceptsandtreatmentoptions AT zhamurkamilova microscopicpolyangiitismodernconceptsandtreatmentoptions AT tvbeketova microscopicpolyangiitismodernconceptsandtreatmentoptions |