Informativeness of markers of systemic inflammation in patients with stable ischemic heart disease: influence of depressive symptoms and restenosis in anamnesis
Objective: the aim of the study was to investigate laboratory markers of inflammation in patients with stable ischemic heart disease, to estimate their interrelation with symptoms of depression. Matherials and methods: 46 men aged from 46 to 75 years hospitalized for the conservative (n = 20) and su...
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2018-03-01
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| Series: | Медицинский вестник Юга России |
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| Online Access: | https://www.medicalherald.ru/jour/article/view/661 |
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| author | I. N. Orekhova D. N. Ivanchenko N. P. Dorofeeva V. Y. Martirosov S. V. Shlyk |
| author_facet | I. N. Orekhova D. N. Ivanchenko N. P. Dorofeeva V. Y. Martirosov S. V. Shlyk |
| author_sort | I. N. Orekhova |
| collection | DOAJ |
| description | Objective: the aim of the study was to investigate laboratory markers of inflammation in patients with stable ischemic heart disease, to estimate their interrelation with symptoms of depression. Matherials and methods: 46 men aged from 46 to 75 years hospitalized for the conservative (n = 20) and surgical (n = 26) treatment of ischemic heart disease participated in the study. An evaluation of inflammatory markers (absolute quantity of leukocytes and neutrophils, monocyte/HDL ratio and neutrophil/lymphocyte ratio) was performed. Depressive symptoms were measured using the CES-D scale. Conclusions: symptoms of depression were found in 8 patients (17,37%). 13% of them had symptoms of mild depression, 4,37% - symptoms of severe depression. The monocyte/HDL ratio was significantly higher in patients with ischemic heart disease comparing to healthy individuals. The monocyte/HDL ratio was significantly increased in patients with depressive symptoms, previously implanted stent, restenosis of the coronary stent in anamnesis. Level of leukocytes was higher during the early period after the procedure of percutaneous coronary intervention with stenting and in patients with stent restenosis. Number of neutrophils and the neutrophil/lymphocyte ratio were significantly higher in patients with depression symptoms, during the early period after stent implantation and also with previous restenosis of the stent. Systemic inflammation estimated using routine laboratory tests was significantly higher in both patients with complicated ischemic heart disease, and with symptoms of depressive disorder. Routine laboratory indicators can be informative in assessing inflammation in patients with ischemic heart disease. Symptoms of depression and stent restenosis can be followed by increased inflammatory markers. |
| format | Article |
| id | doaj-art-a8454e35a04f4b0d96bcc6ecf67e4b56 |
| institution | Matheson Library |
| issn | 2219-8075 2618-7876 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj-art-a8454e35a04f4b0d96bcc6ecf67e4b562025-07-03T16:13:39ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762018-03-0191707910.21886/2219-8075-2018-9-1-70-79439Informativeness of markers of systemic inflammation in patients with stable ischemic heart disease: influence of depressive symptoms and restenosis in anamnesisI. N. Orekhova0D. N. Ivanchenko1N. P. Dorofeeva2V. Y. Martirosov3S. V. Shlyk4Rostov State Medical University, Rostov-on-DonRostov State Medical University, Rostov-on-DonRostov State Medical University, Rostov-on-DonRostov State Medical University, Rostov-on-DonRostov State Medical University, Rostov-on-DonObjective: the aim of the study was to investigate laboratory markers of inflammation in patients with stable ischemic heart disease, to estimate their interrelation with symptoms of depression. Matherials and methods: 46 men aged from 46 to 75 years hospitalized for the conservative (n = 20) and surgical (n = 26) treatment of ischemic heart disease participated in the study. An evaluation of inflammatory markers (absolute quantity of leukocytes and neutrophils, monocyte/HDL ratio and neutrophil/lymphocyte ratio) was performed. Depressive symptoms were measured using the CES-D scale. Conclusions: symptoms of depression were found in 8 patients (17,37%). 13% of them had symptoms of mild depression, 4,37% - symptoms of severe depression. The monocyte/HDL ratio was significantly higher in patients with ischemic heart disease comparing to healthy individuals. The monocyte/HDL ratio was significantly increased in patients with depressive symptoms, previously implanted stent, restenosis of the coronary stent in anamnesis. Level of leukocytes was higher during the early period after the procedure of percutaneous coronary intervention with stenting and in patients with stent restenosis. Number of neutrophils and the neutrophil/lymphocyte ratio were significantly higher in patients with depression symptoms, during the early period after stent implantation and also with previous restenosis of the stent. Systemic inflammation estimated using routine laboratory tests was significantly higher in both patients with complicated ischemic heart disease, and with symptoms of depressive disorder. Routine laboratory indicators can be informative in assessing inflammation in patients with ischemic heart disease. Symptoms of depression and stent restenosis can be followed by increased inflammatory markers.https://www.medicalherald.ru/jour/article/view/661depressioninflammationleukocytesischemic heart diseasepercutaneous coronary interventionrestenosis |
| spellingShingle | I. N. Orekhova D. N. Ivanchenko N. P. Dorofeeva V. Y. Martirosov S. V. Shlyk Informativeness of markers of systemic inflammation in patients with stable ischemic heart disease: influence of depressive symptoms and restenosis in anamnesis Медицинский вестник Юга России depression inflammation leukocytes ischemic heart disease percutaneous coronary intervention restenosis |
| title | Informativeness of markers of systemic inflammation in patients with stable ischemic heart disease: influence of depressive symptoms and restenosis in anamnesis |
| title_full | Informativeness of markers of systemic inflammation in patients with stable ischemic heart disease: influence of depressive symptoms and restenosis in anamnesis |
| title_fullStr | Informativeness of markers of systemic inflammation in patients with stable ischemic heart disease: influence of depressive symptoms and restenosis in anamnesis |
| title_full_unstemmed | Informativeness of markers of systemic inflammation in patients with stable ischemic heart disease: influence of depressive symptoms and restenosis in anamnesis |
| title_short | Informativeness of markers of systemic inflammation in patients with stable ischemic heart disease: influence of depressive symptoms and restenosis in anamnesis |
| title_sort | informativeness of markers of systemic inflammation in patients with stable ischemic heart disease influence of depressive symptoms and restenosis in anamnesis |
| topic | depression inflammation leukocytes ischemic heart disease percutaneous coronary intervention restenosis |
| url | https://www.medicalherald.ru/jour/article/view/661 |
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