A genetic safeguard for eliminating target genes in synthetic probiotics in a gut environment

Summary: To meet the emerging demand for constraining engineered probiotic activities, many biocontainment studies explore strategies that involve killing engineered microbes, which often create basal levels of cytotoxicity that hamper cell fitness and performance. Here, we explored a circuit design...

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Bibliographic Details
Main Authors: Nhu Nguyen, Miaomiao Wang, Lin Li, Clement T.Y. Chan
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422501288X
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