Histiocytic neoplasms: modern aspects of pathogenesis, classification, diagnosis and treatment
Histiocytic cell tumors present as a difficult group of diseases in terms of differential diagnosis due to their rare frequency, heterogeneous clinical manifestations and ambiguous clinical course. Considering MAPK-signaling pathway mutations role (including BRAFV600E) in the pathogenesis of histioc...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-01-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/515 |
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| author | O. D. Gurieva T. T. Valiev A. I. Pavlovskaya |
| author_facet | O. D. Gurieva T. T. Valiev A. I. Pavlovskaya |
| author_sort | O. D. Gurieva |
| collection | DOAJ |
| description | Histiocytic cell tumors present as a difficult group of diseases in terms of differential diagnosis due to their rare frequency, heterogeneous clinical manifestations and ambiguous clinical course. Considering MAPK-signaling pathway mutations role (including BRAFV600E) in the pathogenesis of histiocytic cell tumors the importance of genetic studies in the diagnosis and choice of therapeutic strategy in these diseases increases. In the current issue modern classifications of histiocytic cell tumors, morphological and immunophenotypic features of histiocytic and dendritic cells, and the role of recurrent somatic mutations of the MAPK signaling pathway in the pathological histiocytic proliferation are presented. Particular attention is given to Langerhans cell histiocytosis, Erdheim–Chester disease and juvenile xanthogranuloma. Clinical and diagnostic characteristics of these diseases and therapeutic approaches are presented. |
| format | Article |
| id | doaj-art-a7cd28b4548c454b93dfd2c5c3373f02 |
| institution | Matheson Library |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2022-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-a7cd28b4548c454b93dfd2c5c3373f022025-08-04T13:57:51ZrusABV-pressОнкогематология1818-83462413-40232022-01-01171102510.17650/1818-8346-2022-17-1-10-25418Histiocytic neoplasms: modern aspects of pathogenesis, classification, diagnosis and treatmentO. D. Gurieva0T. T. Valiev1A. I. Pavlovskaya2N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaHistiocytic cell tumors present as a difficult group of diseases in terms of differential diagnosis due to their rare frequency, heterogeneous clinical manifestations and ambiguous clinical course. Considering MAPK-signaling pathway mutations role (including BRAFV600E) in the pathogenesis of histiocytic cell tumors the importance of genetic studies in the diagnosis and choice of therapeutic strategy in these diseases increases. In the current issue modern classifications of histiocytic cell tumors, morphological and immunophenotypic features of histiocytic and dendritic cells, and the role of recurrent somatic mutations of the MAPK signaling pathway in the pathological histiocytic proliferation are presented. Particular attention is given to Langerhans cell histiocytosis, Erdheim–Chester disease and juvenile xanthogranuloma. Clinical and diagnostic characteristics of these diseases and therapeutic approaches are presented.https://oncohematology.abvpress.ru/ongm/article/view/515histiocytic neoplasmlangerhans cell histiocytosiserdheim–chester diseasejuvenile xanthogranulomamapk signaling pathwaybrafv600e mutationdiagnosistreatment |
| spellingShingle | O. D. Gurieva T. T. Valiev A. I. Pavlovskaya Histiocytic neoplasms: modern aspects of pathogenesis, classification, diagnosis and treatment Онкогематология histiocytic neoplasm langerhans cell histiocytosis erdheim–chester disease juvenile xanthogranuloma mapk signaling pathway brafv600e mutation diagnosis treatment |
| title | Histiocytic neoplasms: modern aspects of pathogenesis, classification, diagnosis and treatment |
| title_full | Histiocytic neoplasms: modern aspects of pathogenesis, classification, diagnosis and treatment |
| title_fullStr | Histiocytic neoplasms: modern aspects of pathogenesis, classification, diagnosis and treatment |
| title_full_unstemmed | Histiocytic neoplasms: modern aspects of pathogenesis, classification, diagnosis and treatment |
| title_short | Histiocytic neoplasms: modern aspects of pathogenesis, classification, diagnosis and treatment |
| title_sort | histiocytic neoplasms modern aspects of pathogenesis classification diagnosis and treatment |
| topic | histiocytic neoplasm langerhans cell histiocytosis erdheim–chester disease juvenile xanthogranuloma mapk signaling pathway brafv600e mutation diagnosis treatment |
| url | https://oncohematology.abvpress.ru/ongm/article/view/515 |
| work_keys_str_mv | AT odgurieva histiocyticneoplasmsmodernaspectsofpathogenesisclassificationdiagnosisandtreatment AT ttvaliev histiocyticneoplasmsmodernaspectsofpathogenesisclassificationdiagnosisandtreatment AT aipavlovskaya histiocyticneoplasmsmodernaspectsofpathogenesisclassificationdiagnosisandtreatment |