The Effect of a Traditional Product, Hazelnut-Zante Currant Mixture, on an Animal Model of Autism
Background and objectives: Autism spectrum disorder (ASD) is a complicated disorder. Hazelnut and Zante can be of great importance in controlling autism due to their high antioxidant and anti-inflammatory capacities. Methods: Zante currant was mixed with distilled water and condensed. Hazelnut and h...
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| Format: | Article |
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Iranian Society of Pharmacognosy
2025-07-01
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| Series: | Research Journal of Pharmacognosy |
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| Online Access: | https://www.rjpharmacognosy.ir/article_221692_0ec502bc9c03b624e06178dc7a2927dd.pdf |
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| author | Neda Orouji Mohammad-Reza Zarrindast Mitra-Sadat Sadat-Shirazi Amir Hossein Memari Mehrdad Karimi Arman Zargaran* |
| author_facet | Neda Orouji Mohammad-Reza Zarrindast Mitra-Sadat Sadat-Shirazi Amir Hossein Memari Mehrdad Karimi Arman Zargaran* |
| author_sort | Neda Orouji |
| collection | DOAJ |
| description | Background and objectives: Autism spectrum disorder (ASD) is a complicated disorder. Hazelnut and Zante can be of great importance in controlling autism due to their high antioxidant and anti-inflammatory capacities. Methods: Zante currant was mixed with distilled water and condensed. Hazelnut and honey were added afterwards. The mixture was diluted with distilled water to obtain the final product hazelnut-Zante currant mixture. Twenty-four female rats were used, with pregnant rats divided into two groups: one receiving saline and designated as non-autistic rats, and the other receiving sodium valproate and designated as autistic rats. Offspring from both groups were further divided into subgroups, receiving either tap water or hazelnut-Zante currant mixture from postnatal day 30 to 65. Social interaction and elevated plus maze tests were conducted to assess the sociability and anxiety-like behavior. The prefrontal cortex (PFC) and amygdala were collected for analysis. Results: Administering hazelnut-Zante currant mixture for one month significantly improved sociability and reduced anxiety-like behavior in autistic animals. Autistic rats exhibited elevated levels of aspartate, glutamate, interleukin 1-β, and tumor necrosis factor α (TNF-α) in the brain, along with decreased superoxide dismutase (SOD) levels in the PFC and amygdala. The result did not show notable changes in SOD, interleukin 1-β, and TNF-α levels in either the amygdala or prefrontal cortex. Conclusions: Our findings suggest that this herbal mixture could serve as a promising non-pharmacological candidate for alleviating the behavioral symptoms of ASD. |
| format | Article |
| id | doaj-art-a76b972c8e4e4faabc3f301f3ca9866e |
| institution | Matheson Library |
| issn | 2345-4458 2345-5977 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Iranian Society of Pharmacognosy |
| record_format | Article |
| series | Research Journal of Pharmacognosy |
| spelling | doaj-art-a76b972c8e4e4faabc3f301f3ca9866e2025-07-08T09:26:10ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772025-07-01123496610.22127/rjp.2025.485802.2639221692The Effect of a Traditional Product, Hazelnut-Zante Currant Mixture, on an Animal Model of AutismNeda Orouji0Mohammad-Reza Zarrindast1Mitra-Sadat Sadat-Shirazi2Amir Hossein Memari3Mehrdad Karimi4Arman Zargaran*5Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.Sport Medicine Research Center, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Science, Tehran, Iran.Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.Background and objectives: Autism spectrum disorder (ASD) is a complicated disorder. Hazelnut and Zante can be of great importance in controlling autism due to their high antioxidant and anti-inflammatory capacities. Methods: Zante currant was mixed with distilled water and condensed. Hazelnut and honey were added afterwards. The mixture was diluted with distilled water to obtain the final product hazelnut-Zante currant mixture. Twenty-four female rats were used, with pregnant rats divided into two groups: one receiving saline and designated as non-autistic rats, and the other receiving sodium valproate and designated as autistic rats. Offspring from both groups were further divided into subgroups, receiving either tap water or hazelnut-Zante currant mixture from postnatal day 30 to 65. Social interaction and elevated plus maze tests were conducted to assess the sociability and anxiety-like behavior. The prefrontal cortex (PFC) and amygdala were collected for analysis. Results: Administering hazelnut-Zante currant mixture for one month significantly improved sociability and reduced anxiety-like behavior in autistic animals. Autistic rats exhibited elevated levels of aspartate, glutamate, interleukin 1-β, and tumor necrosis factor α (TNF-α) in the brain, along with decreased superoxide dismutase (SOD) levels in the PFC and amygdala. The result did not show notable changes in SOD, interleukin 1-β, and TNF-α levels in either the amygdala or prefrontal cortex. Conclusions: Our findings suggest that this herbal mixture could serve as a promising non-pharmacological candidate for alleviating the behavioral symptoms of ASD.https://www.rjpharmacognosy.ir/article_221692_0ec502bc9c03b624e06178dc7a2927dd.pdfanxietyautism spectrum disorderpersian medicinesocial interaction |
| spellingShingle | Neda Orouji Mohammad-Reza Zarrindast Mitra-Sadat Sadat-Shirazi Amir Hossein Memari Mehrdad Karimi Arman Zargaran* The Effect of a Traditional Product, Hazelnut-Zante Currant Mixture, on an Animal Model of Autism Research Journal of Pharmacognosy anxiety autism spectrum disorder persian medicine social interaction |
| title | The Effect of a Traditional Product, Hazelnut-Zante Currant Mixture, on an Animal Model of Autism |
| title_full | The Effect of a Traditional Product, Hazelnut-Zante Currant Mixture, on an Animal Model of Autism |
| title_fullStr | The Effect of a Traditional Product, Hazelnut-Zante Currant Mixture, on an Animal Model of Autism |
| title_full_unstemmed | The Effect of a Traditional Product, Hazelnut-Zante Currant Mixture, on an Animal Model of Autism |
| title_short | The Effect of a Traditional Product, Hazelnut-Zante Currant Mixture, on an Animal Model of Autism |
| title_sort | effect of a traditional product hazelnut zante currant mixture on an animal model of autism |
| topic | anxiety autism spectrum disorder persian medicine social interaction |
| url | https://www.rjpharmacognosy.ir/article_221692_0ec502bc9c03b624e06178dc7a2927dd.pdf |
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