Metformin pretreatment ameliorates busulfan-induced liver endothelial toxicity during haematopoietic stem cell transplantation.

Metformin pretreatment ameliorates busulfan-induced liver endothelial toxicity during haematopoietic stem cell transplantation.

The success of Haematopoietic cell transplantation (HCT) is often limited by regimen-related toxicity (RRT) caused by conditioning regimen drugs. Among different conditioning drugs, busulfan (Bu) and treosulfan (Treo), although widely used in HCT, exhibit different toxicity profiles, the mechanism o...

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Main Authors: Balaji Balakrishnan, Raveen Stephen Stallon Illangeswaran, Bharathi Murugan Rajamani, Arun Kumar Arunachalam, Aswin Anand Pai, Ezhilpavai Mohanan, Alok Srivastava, Vikram Mathews, Poonkuzhali Balasubramanian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0293311&type=printable
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