A Modular Biomimetic Preclinical Platform to Elucidate the Interaction Between Cancer Cells and the Bone Metastatic Niche

A Modular Biomimetic Preclinical Platform to Elucidate the Interaction Between Cancer Cells and the Bone Metastatic Niche

Breast cancer (BC) frequently metastasizes to bone, leading to poor patient prognosis. The infiltration of cancer cells in bone impairs its homeostasis, triggering a pathological interaction between tumors and resident cells. Preclinical models able to mimic the bone microenvironment are needed to a...

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Bibliographic Details
Main Authors: Claudia Cocchi, Massimiliano Dapporto, Ania Naila Guerrieri, Chiara Liverani, Marta Tavoni, Chiara Bellotti, Chiara Spadazzi, Anna Tampieri, Marco Gambarotti, Giacomo Miserocchi, Simone Sprio, Enrico Lucarelli, Michele Iafisco, Toni Ibrahim, Alessandro De Vita, Laura Mercatali
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Journal of Functional Biomaterials
Subjects:
bone metastasis
breast cancer
preclinical platform
tricalcium phosphate cements
osteoclasts
osteoblasts
Online Access:https://www.mdpi.com/2079-4983/16/6/220
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