Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients
Abstract Background Due to limited inpatient care resources and high healthcare expenditures, understanding factors that affect lengths of stay (LOS) is highly relevant. We aimed to investigate associations between metabolic disturbances and LOS in a psychiatric hospital and to identify other clin...
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Cambridge University Press
2025-01-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933825100369/type/journal_article |
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| author | Nermine Laaboub Setareh Ranjbar Séverine Crettol Nicolas Ansermot Frederik Vandenberghe Carole Grandjean Marianna Piras Julien Elowe Martin Preisig Armin Von Gunten Philippe Conus Chin Bin Eap |
| author_facet | Nermine Laaboub Setareh Ranjbar Séverine Crettol Nicolas Ansermot Frederik Vandenberghe Carole Grandjean Marianna Piras Julien Elowe Martin Preisig Armin Von Gunten Philippe Conus Chin Bin Eap |
| author_sort | Nermine Laaboub |
| collection | DOAJ |
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Abstract
Background
Due to limited inpatient care resources and high healthcare expenditures, understanding factors that affect lengths of stay (LOS) is highly relevant. We aimed to investigate associations between metabolic disturbances and LOS in a psychiatric hospital and to identify other clinical and sociodemographic LOS predictors.
Methods
Patients admitted to one of the units of the general psychiatric or psychogeriatric departments between January 1, 2007 and December 31, 2020, were included. Metabolic disturbances (i.e., the metabolic syndrome and its five components) were defined using the International Diabetes Federation definition. Cox frailty regression models with time-varying coefficients were used to investigate the association between metabolic disturbances and LOS. Hazard ratios (HR) >1 and HR < 1 indicated the relative likelihood of shorter and extended LOS, respectively.
Results
A total of 7,771 patients for 16,959 hospital stays throughout 14 years of follow-up were included. Central obesity (HR = 0.82; 95% confidence interval [CI] = [0.76–0.89]), hyperglycemia (HR = 0.83; 95% CI = [0.78–0.89]), hypertriglyceridemia (HR = 0.87; 95% CI = [0.80–0.92]), and the metabolic syndrome (HR = 0.76; 95% CI = [0.70–0.82]) were associated with an increased risk of extended LOS in the psychiatric hospital, while underweight (HR = 1.30, 95% CI = [1.09–1.56]) and HDL hypocholesterolemia (HR = 1.10, 95% CI = [1.03–1.18]) were associated with a higher likelihood of shorter LOS. In first-episode psychosis patients, hypertriglyceridemia (HR = 0.82; 95% CI = [0.67–0.99]) and hypertension (HR = 0.76, 95% CI = [0.58–0.99]) were associated with extended LOS when considering all stays, while no association was found when considering the first stay per patient.
Conclusion
Future studies should determine whether better metabolic monitoring and treatment of metabolic disturbances can contribute to reducing LOS.
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| format | Article |
| id | doaj-art-a68da9a122f8442b80c1f6c1802c534d |
| institution | Matheson Library |
| issn | 0924-9338 1778-3585 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
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| series | European Psychiatry |
| spelling | doaj-art-a68da9a122f8442b80c1f6c1802c534d2025-07-18T09:18:05ZengCambridge University PressEuropean Psychiatry0924-93381778-35852025-01-016810.1192/j.eurpsy.2025.10036Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patientsNermine Laaboub0https://orcid.org/0000-0001-8029-2418Setareh Ranjbar1https://orcid.org/0000-0002-0238-2976Séverine Crettol2https://orcid.org/0000-0003-3790-7194Nicolas Ansermot3https://orcid.org/0000-0001-8350-9416Frederik Vandenberghe4https://orcid.org/0000-0002-8964-2047Carole Grandjean5https://orcid.org/0009-0002-0460-9182Marianna Piras6https://orcid.org/0009-0001-5579-0199Julien Elowe7https://orcid.org/0000-0002-9538-331XMartin Preisig8https://orcid.org/0000-0001-5689-4259Armin Von Gunten9Philippe Conus10Chin Bin Eap11https://orcid.org/0000-0002-5439-0230Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, https://ror.org/05a353079 Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandCenter for Psychiatric Epidemiology and Psychopathology, Department of Psychiatry, https://ror.org/05a353079Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandUnit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, https://ror.org/05a353079 Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandUnit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, https://ror.org/05a353079 Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandUnit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, https://ror.org/05a353079 Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandUnit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, https://ror.org/05a353079 Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandUnit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, https://ror.org/05a353079 Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandService of Adult Psychiatry North-West, Department of Psychiatry, https://ror.org/05a353079Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandCenter for Psychiatric Epidemiology and Psychopathology, Department of Psychiatry, https://ror.org/05a353079Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandService of Old Age Psychiatry, Department of Psychiatry, https://ror.org/05a353079Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandService of General Psychiatry, Department of Psychiatry, https://ror.org/05a353079Lausanne University Hospital, University of Lausanne, Prilly, SwitzerlandUnit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric Neuroscience, Department of Psychiatry, https://ror.org/05a353079 Lausanne University Hospital, University of Lausanne, Prilly, Switzerland Les Toises Psychiatry and Psychotherapy Center, Lausanne, Switzerland University of Lausanne, Lausanne, Switzerland Abstract Background Due to limited inpatient care resources and high healthcare expenditures, understanding factors that affect lengths of stay (LOS) is highly relevant. We aimed to investigate associations between metabolic disturbances and LOS in a psychiatric hospital and to identify other clinical and sociodemographic LOS predictors. Methods Patients admitted to one of the units of the general psychiatric or psychogeriatric departments between January 1, 2007 and December 31, 2020, were included. Metabolic disturbances (i.e., the metabolic syndrome and its five components) were defined using the International Diabetes Federation definition. Cox frailty regression models with time-varying coefficients were used to investigate the association between metabolic disturbances and LOS. Hazard ratios (HR) >1 and HR < 1 indicated the relative likelihood of shorter and extended LOS, respectively. Results A total of 7,771 patients for 16,959 hospital stays throughout 14 years of follow-up were included. Central obesity (HR = 0.82; 95% confidence interval [CI] = [0.76–0.89]), hyperglycemia (HR = 0.83; 95% CI = [0.78–0.89]), hypertriglyceridemia (HR = 0.87; 95% CI = [0.80–0.92]), and the metabolic syndrome (HR = 0.76; 95% CI = [0.70–0.82]) were associated with an increased risk of extended LOS in the psychiatric hospital, while underweight (HR = 1.30, 95% CI = [1.09–1.56]) and HDL hypocholesterolemia (HR = 1.10, 95% CI = [1.03–1.18]) were associated with a higher likelihood of shorter LOS. In first-episode psychosis patients, hypertriglyceridemia (HR = 0.82; 95% CI = [0.67–0.99]) and hypertension (HR = 0.76, 95% CI = [0.58–0.99]) were associated with extended LOS when considering all stays, while no association was found when considering the first stay per patient. Conclusion Future studies should determine whether better metabolic monitoring and treatment of metabolic disturbances can contribute to reducing LOS. https://www.cambridge.org/core/product/identifier/S0924933825100369/type/journal_articlelengths of staymetabolic disturbancesmetabolic syndromepsychiatry |
| spellingShingle | Nermine Laaboub Setareh Ranjbar Séverine Crettol Nicolas Ansermot Frederik Vandenberghe Carole Grandjean Marianna Piras Julien Elowe Martin Preisig Armin Von Gunten Philippe Conus Chin Bin Eap Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients European Psychiatry lengths of stay metabolic disturbances metabolic syndrome psychiatry |
| title | Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients |
| title_full | Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients |
| title_fullStr | Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients |
| title_full_unstemmed | Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients |
| title_short | Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients |
| title_sort | metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital results from a swiss psychiatric cohort and first episode psychosis patients |
| topic | lengths of stay metabolic disturbances metabolic syndrome psychiatry |
| url | https://www.cambridge.org/core/product/identifier/S0924933825100369/type/journal_article |
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