Prospects for the use of sialylated immunoglobulins in the treatment of different diseases
The central role of glycosylation has been well confirmed in numerous studies. In particular, a change in the glycosylation profile of antibodies is observed in infectious diseases, autoimmune disorders and cancer. The analysis of antibody glycosylation can lead to a promising improvement of existin...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2020-06-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/270 |
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| _version_ | 1839591849797353472 |
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| author | Yu. V. Markina A. M. Markin I. A. Sobenin A. N. Orekhov |
| author_facet | Yu. V. Markina A. M. Markin I. A. Sobenin A. N. Orekhov |
| author_sort | Yu. V. Markina |
| collection | DOAJ |
| description | The central role of glycosylation has been well confirmed in numerous studies. In particular, a change in the glycosylation profile of antibodies is observed in infectious diseases, autoimmune disorders and cancer. The analysis of antibody glycosylation can lead to a promising improvement of existing strategies for the disease diagnosis. Specific changes in immunoglobulin glycan molecules can be used in the targeted therapy of multiple diseases, emphasizing the importance of glycans in antibody effector function. Altogether, use of sialylated immunoglobulins may contribute to the next breakthrough in the development of therapeutic drugs and vaccines of the next generation. |
| format | Article |
| id | doaj-art-a679228e4f5d4cea8bacb78e29cb5ea2 |
| institution | Matheson Library |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2020-06-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-a679228e4f5d4cea8bacb78e29cb5ea22025-08-03T12:59:24ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412020-06-015211211810.23946/2500-0764-2020-5-2-112-118209Prospects for the use of sialylated immunoglobulins in the treatment of different diseasesYu. V. Markina0A. M. Markin1I. A. Sobenin2A. N. Orekhov3Research Institute of Human MorphologyResearch Institute of Human MorphologyNational Medical Cardiology Research CenterResearch Institute of Human Morphology; Research Institute of Pathology and PathophysiologyThe central role of glycosylation has been well confirmed in numerous studies. In particular, a change in the glycosylation profile of antibodies is observed in infectious diseases, autoimmune disorders and cancer. The analysis of antibody glycosylation can lead to a promising improvement of existing strategies for the disease diagnosis. Specific changes in immunoglobulin glycan molecules can be used in the targeted therapy of multiple diseases, emphasizing the importance of glycans in antibody effector function. Altogether, use of sialylated immunoglobulins may contribute to the next breakthrough in the development of therapeutic drugs and vaccines of the next generation.https://fcm.kemsmu.ru/jour/article/view/270glycansimmunoglobulinsantibodiesinflammationsialylation |
| spellingShingle | Yu. V. Markina A. M. Markin I. A. Sobenin A. N. Orekhov Prospects for the use of sialylated immunoglobulins in the treatment of different diseases Фундаментальная и клиническая медицина glycans immunoglobulins antibodies inflammation sialylation |
| title | Prospects for the use of sialylated immunoglobulins in the treatment of different diseases |
| title_full | Prospects for the use of sialylated immunoglobulins in the treatment of different diseases |
| title_fullStr | Prospects for the use of sialylated immunoglobulins in the treatment of different diseases |
| title_full_unstemmed | Prospects for the use of sialylated immunoglobulins in the treatment of different diseases |
| title_short | Prospects for the use of sialylated immunoglobulins in the treatment of different diseases |
| title_sort | prospects for the use of sialylated immunoglobulins in the treatment of different diseases |
| topic | glycans immunoglobulins antibodies inflammation sialylation |
| url | https://fcm.kemsmu.ru/jour/article/view/270 |
| work_keys_str_mv | AT yuvmarkina prospectsfortheuseofsialylatedimmunoglobulinsinthetreatmentofdifferentdiseases AT ammarkin prospectsfortheuseofsialylatedimmunoglobulinsinthetreatmentofdifferentdiseases AT iasobenin prospectsfortheuseofsialylatedimmunoglobulinsinthetreatmentofdifferentdiseases AT anorekhov prospectsfortheuseofsialylatedimmunoglobulinsinthetreatmentofdifferentdiseases |