Longitudinal profiling of hormone receptor positive, HER2 negative metastatic breast cancer through droplet digital PCR-based circulating tumor DNA fragmentomics

Longitudinal profiling of hormone receptor positive, HER2 negative metastatic breast cancer through droplet digital PCR-based circulating tumor DNA fragmentomics

Background: In the context of hormone receptor positive, HER2 negative Metastatic breast cancer (MBC), CDK 4/6 inhibitors (CDK4/6i) combined with endocrine therapy represent the standard first-line treatment, improving Progression-Free Survival (PFS) and Overall Survival (OS). Despite these benefits...

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Main Authors: Lorenzo Foffano, Alessandra Franzoni, Elisabetta Molteni, Fabiola Giudici, Arianna Dri, Debora Basile, Linda Cucciniello, Silvia Buriolla, Claudia Noto, Stefania Russo, Elena Nascimbeni, Silvia Bolzonello, Brenno Pastò, Serena Della Rossa, Lorenzo Allegri, Marta Bonotto, Alessandro Marco Minisini, Barbara Belletti, Giuseppe Damante, Lorenzo Gerratana, Fabio Puglisi
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Translational Oncology
Subjects:
Metastatic breast cancer
Liquid biopsy
Fragmentomics
Circulating tumor DNA
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001871
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