Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)
Introduction: The morbidity associated with left pancreatectomy (LP) is estimated at 20–25 % for major complications, with a mortality rate of 1–3 %. Diagnosing incidental pancreatic lesions, combined with an aging population and increased comorbidities, presents complex therapeutic challenges. This...
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2025-07-01
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| author | Belinda Sanchez-Pérez Candido F. Alcazar-Lopez Mario Serradilla-Martin Celia Villodres-Tudela Belen Hernández Julio Santoyo Santoyo Jose Manuel Ramia Juli Busquets Luis Secanella Nuria Peláez Maialen Alkorta Itziar De Ariño Hervas Mar Achalandabaso Boira Enrique Toledo Fernando Rotellar Pablo Martí-Cruchaga Miguel Ángel Gómez-Bravo Gonzalo Suárez Marina Garcés-Albir Luis Sabater Gabriel García Francisco Javier Alcalá Enrique Asensio David Pacheco Esteban Cugat Francisco Espín María Galófre Jorge Calvo Carmelo Loinaz M.I. García-Domingo Santiago Sánchez-Cabús Belén Martín Gerardo Blanco-Fernández Isabel Jaen-Torrejimeno Carlos Domingo del Pozo Carmen Payá Carmen González Sandra Ruiz Rafael López-Andújar Cristina Ballester Ana Belén Vico Natalia Zambudio Sergio Estévez Manuel Nogueira-Sixto José Ignacio Miota Belén Conde Miguel Ángel Suárez Jorge Roldán de la Rua Angelica Blanco Manuel González Pilar Elena González Betsabé Reyes Santiago López Ben Berta Tió Javier Mínguez García Inmaculada Lasa Unzúe Alberto Miyar Lorena Solar Fernando Burdio Benedetto Ielpo Alberto Carabias María Paloma Alfredo Escartín Fulthon Vela Elia Marqués Adelino Pérez Gloria Palomares Antonio Calvo José Tomás Castell María Jesús Castro M. Carmen Manzanares Enrique Artiguez Juan Luis Blas Luis Diez Alicia Calero Luis Muñoz Mario Rodríguez Daniel Aparicio-Lopez Juan J. Rubio-Garcia |
| author_facet | Belinda Sanchez-Pérez Candido F. Alcazar-Lopez Mario Serradilla-Martin Celia Villodres-Tudela Belen Hernández Julio Santoyo Santoyo Jose Manuel Ramia Juli Busquets Luis Secanella Nuria Peláez Maialen Alkorta Itziar De Ariño Hervas Mar Achalandabaso Boira Enrique Toledo Fernando Rotellar Pablo Martí-Cruchaga Miguel Ángel Gómez-Bravo Gonzalo Suárez Marina Garcés-Albir Luis Sabater Gabriel García Francisco Javier Alcalá Enrique Asensio David Pacheco Esteban Cugat Francisco Espín María Galófre Jorge Calvo Carmelo Loinaz M.I. García-Domingo Santiago Sánchez-Cabús Belén Martín Gerardo Blanco-Fernández Isabel Jaen-Torrejimeno Carlos Domingo del Pozo Carmen Payá Carmen González Sandra Ruiz Rafael López-Andújar Cristina Ballester Ana Belén Vico Natalia Zambudio Sergio Estévez Manuel Nogueira-Sixto José Ignacio Miota Belén Conde Miguel Ángel Suárez Jorge Roldán de la Rua Angelica Blanco Manuel González Pilar Elena González Betsabé Reyes Santiago López Ben Berta Tió Javier Mínguez García Inmaculada Lasa Unzúe Alberto Miyar Lorena Solar Fernando Burdio Benedetto Ielpo Alberto Carabias María Paloma Alfredo Escartín Fulthon Vela Elia Marqués Adelino Pérez Gloria Palomares Antonio Calvo José Tomás Castell María Jesús Castro M. Carmen Manzanares Enrique Artiguez Juan Luis Blas Luis Diez Alicia Calero Luis Muñoz Mario Rodríguez Daniel Aparicio-Lopez Juan J. Rubio-Garcia |
| author_sort | Belinda Sanchez-Pérez |
| collection | DOAJ |
| description | Introduction: The morbidity associated with left pancreatectomy (LP) is estimated at 20–25 % for major complications, with a mortality rate of 1–3 %. Diagnosing incidental pancreatic lesions, combined with an aging population and increased comorbidities, presents complex therapeutic challenges. This uncertainty raises the question of whether LP presents different morbidity and mortality profiles depending on the neoplasm type, potentially aiding decision-making. Objective: To compare postoperative outcomes by tumor type in a prospective series of LPs in Spain. Methods: The SPANDISPAN Project is a prospective, multicenter, observational study conducted in hepato-pancreato-biliary units from February 2022 to January 2023. A total of 311 patients from 41 Spanish centers participated. Patients were categorized by etiology: Adenocarcinoma (ADC), Intraductal Papillary Mucinous + Mucinous Cystic Neoplasms (IPMN + MCN), Neuroendocrine Tumors (NET), and Others. Pancreatic surgery-specific complications were defined by the International Study Group on Pancreatic Surgery (ISGPS). Results: Postoperative complications were similar overall and for Clavien-Dindo grade > II. No significant differences were observed in POPF, except that grade B/C was more frequent in NET (29.6 %, p < 0.039), mainly due to grade B (53.3 %). No differences were found in PPH or DGE, though the severity of hemorrhage differed significantly (p < 0.035), with grade B more common in Others and grade C in NET (66.7 %). Conclusion: No significant differences in complication rates were found based on etiology. Non-functioning NETs in elderly patients should be carefully assessed due to the increased severity of POPF, PPH, and reoperation rates. |
| format | Article |
| id | doaj-art-a5d45c8a84d948a08e13f83747ea2a4f |
| institution | Matheson Library |
| issn | 1015-9584 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj-art-a5d45c8a84d948a08e13f83747ea2a4f2025-06-27T05:49:56ZengElsevierAsian Journal of Surgery1015-95842025-07-0148741374143Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN)Belinda Sanchez-Pérez0Candido F. Alcazar-Lopez1Mario Serradilla-Martin2Celia Villodres-Tudela3Belen Hernández4Julio Santoyo Santoyo5Jose Manuel Ramia6Juli Busquets7Luis Secanella8Nuria Peláez9Maialen Alkorta10Itziar De Ariño Hervas11Mar Achalandabaso Boira12Enrique Toledo13Fernando Rotellar14Pablo Martí-Cruchaga15Miguel Ángel Gómez-Bravo16Gonzalo Suárez17Marina Garcés-Albir18Luis Sabater19Gabriel García20Francisco Javier Alcalá21Enrique Asensio22David Pacheco23Esteban Cugat24Francisco Espín25María Galófre26Jorge Calvo27Carmelo Loinaz28M.I. García-Domingo29Santiago Sánchez-Cabús30Belén Martín31Gerardo Blanco-Fernández32Isabel Jaen-Torrejimeno33Carlos Domingo del Pozo34Carmen Payá35Carmen González36Sandra Ruiz37Rafael López-Andújar38Cristina Ballester39Ana Belén Vico40Natalia Zambudio41Sergio Estévez42Manuel Nogueira-Sixto43José Ignacio Miota44Belén Conde45Miguel Ángel Suárez46Jorge Roldán de la Rua47Angelica Blanco48Manuel González49Pilar Elena González50Betsabé Reyes51Santiago López Ben52Berta Tió53Javier Mínguez García54Inmaculada Lasa Unzúe55Alberto Miyar56Lorena Solar57Fernando Burdio58Benedetto Ielpo59Alberto Carabias60María Paloma61Alfredo Escartín62Fulthon Vela63Elia Marqués64Adelino Pérez65Gloria Palomares66Antonio Calvo67José Tomás Castell68María Jesús Castro69M. Carmen Manzanares70Enrique Artiguez71Juan Luis Blas72Luis Diez73Alicia Calero74Luis Muñoz75Mario Rodríguez76Daniel Aparicio-Lopez77Juan J. Rubio-Garcia78Department of Surgery, Hospital Regional Universitario de Malaga, Malaga, Spain; Corresponding author.Deparment of Surgery, Hospital General Universitario Dr Balmis, Alicante, Spain; ISABIAL, Alicante, Spain; Miguel Hernández University, Alicante, SpainDepartment of Surgery, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria ibs. GRANADA, School of Medicine, University of Granada, Granada, SpainDeparment of Surgery, Hospital General Universitario Dr Balmis, Alicante, Spain; ISABIAL, Alicante, Spain; Miguel Hernández University, Alicante, SpainDepartment of Surgery, Hospital General Universitario de Elda, Alicante, SpainDepartment of Surgery, Hospital Regional Universitario de Malaga, Malaga, SpainDeparment of Surgery, Hospital General Universitario Dr Balmis, Alicante, Spain; ISABIAL, Alicante, Spain; Miguel Hernández University, Alicante, SpainHospital Universitario de Bellvitge, SpainHospital Universitario de Bellvitge, SpainHospital Universitario de Bellvitge, SpainHospital Universitario de Donostia, SpainHospital Universitario de Donostia, SpainHospital Universitario Marqués de Valdecilla, SpainHospital Universitario Marqués de Valdecilla, SpainClínica Universidad de Navarra, SpainClínica Universidad de Navarra, SpainHospital Universitario Virgen del Rocio, SpainHospital Universitario Virgen del Rocio, SpainHospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), SpainHospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), SpainHospital Insular de Gran Canaria, SpainHospital Insular de Gran Canaria, SpainHospital Universitario Rio Ortega, SpainHospital Universitario Rio Ortega, SpainHospital Universitario GermanTrias i Pujol, Spain; Hospital Mutua de Terrassa, SpainHospital Universitario GermanTrias i Pujol, SpainHospital Universitario GermanTrias i Pujol, SpainHospital Universitario Doce de Octubre, SpainHospital Universitario Doce de Octubre, SpainHospital Mutua de Terrassa, SpainHospital de la Santa Creu i Sant Pau, SpainHospital de la Santa Creu i Sant Pau, SpainHospital Universitario de Badajoz, SpainHospital Universitario de Badajoz, SpainHospital Universitario Doctor Peset, SpainHospital Universitario Doctor Peset, SpainHospital Universitario de Basurto, SpainHospital Universitario de Basurto, SpainCIBERehd, Instituto de Salud Carlos III, Madrid, Spain; Department of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, SpainDepartment of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, SpainHospitalUniversitario Virgen de las Nieves, SpainHospitalUniversitario Virgen de las Nieves, SpainComplejo Hospitalario Universitario de Vigo, SpainComplejo Hospitalario Universitario de Vigo, SpainHospital General Universitario de Albacete, SpainHospital General Universitario de Albacete, SpainHospital Universitario Virgen de la Victoria, SpainHospital Universitario Virgen de la Victoria, SpainHospital Universitario De A Coruña, SpainHospital Universitario De A Coruña, SpainHospital Universitario Nuestra Sra. de la Candelaria, SpainHospital Universitario Nuestra Sra. de la Candelaria, SpainHospital Universitario Josep Trueta, SpainHospital Universitario Josep Trueta, SpainHospital Universitario Príncipe de Asturias, SpainHospital Universitario Príncipe de Asturias, SpainHospital Universitario Central de Asturias, SpainHospital Universitario Central de Asturias, SpainHospital del Mar, SpainHospital del Mar, SpainHospital Universitario de Getafe, SpainHospital Universitario de Getafe, SpainHospital Universitario Arnau de Vilanova, SpainHospital Universitario Arnau de Vilanova, SpainHospital Universitario Infanta Leonor, SpainHospital Universitario Infanta Leonor, SpainHospital Universitario Morales Meseguer, SpainHospital Universitario Morales Meseguer, SpainClínica La Luz, SpainHospital Universitario de Bellvitge, Spain; Hospital Universitario de Donostia, Spain; Hospital Universitario Marqués de Valdecilla, Spain; Clínica Universidad de Navarra, Spain; Hospital Universitario Virgen del Rocio, Spain; Hospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), Spain; Hospital Insular de Gran Canaria, Spain; Hospital Universitario Rio Ortega, Spain; Hospital Universitario GermanTrias i Pujol, Spain; Hospital Universitario Doce de Octubre, Spain; Hospital Mutua de Terrassa, Spain; Hospital de la Santa Creu i Sant Pau, Spain; Hospital Universitario de Badajoz, Spain; Hospital Universitario Doctor Peset, Spain; Hospital Universitario de Basurto, Spain; Department of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; HospitalUniversitario Virgen de las Nieves, Spain; Complejo Hospitalario Universitario de Vigo, Spain; Hospital General Universitario de Albacete, Spain; Hospital Universitario Virgen de la Victoria, Spain; Hospital Universitario De A Coruña, Spain; Hospital Universitario Nuestra Sra. de la Candelaria, Spain; Hospital Universitario Josep Trueta, Spain; Hospital Universitario Príncipe de Asturias, Spain; Hospital Universitario Central de Asturias, Spain; Hospital del Mar, Spain; Hospital Universitario de Getafe, Spain; Hospital Universitario Arnau de Vilanova, Spain; Hospital Universitario Infanta Leonor, Spain; Hospital Universitario Morales Meseguer, Spain; Clínica La Luz, Spain; Hospital Universitario Miguel Servet, Zaragoza, Spain; Hospital Universitario, Hospital General Universitario Dr Balmis, Alicante, SpainHospital Universitario de Bellvitge, Spain; Hospital Universitario de Donostia, Spain; Hospital Universitario Marqués de Valdecilla, Spain; Clínica Universidad de Navarra, Spain; Hospital Universitario Virgen del Rocio, Spain; Hospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), Spain; Hospital Insular de Gran Canaria, Spain; Hospital Universitario Rio Ortega, Spain; Hospital Universitario GermanTrias i Pujol, Spain; Hospital Universitario Doce de Octubre, Spain; Hospital Mutua de Terrassa, Spain; Hospital de la Santa Creu i Sant Pau, Spain; Hospital Universitario de Badajoz, Spain; Hospital Universitario Doctor Peset, Spain; Hospital Universitario de Basurto, Spain; Department of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; HospitalUniversitario Virgen de las Nieves, Spain; Complejo Hospitalario Universitario de Vigo, Spain; Hospital General Universitario de Albacete, Spain; Hospital Universitario Virgen de la Victoria, Spain; Hospital Universitario De A Coruña, Spain; Hospital Universitario Nuestra Sra. de la Candelaria, Spain; Hospital Universitario Josep Trueta, Spain; Hospital Universitario Príncipe de Asturias, Spain; Hospital Universitario Central de Asturias, Spain; Hospital del Mar, Spain; Hospital Universitario de Getafe, Spain; Hospital Universitario Arnau de Vilanova, Spain; Hospital Universitario Infanta Leonor, Spain; Hospital Universitario Morales Meseguer, Spain; Clínica La Luz, Spain; Hospital Universitario Miguel Servet, Zaragoza, Spain; Hospital Universitario, Hospital General Universitario Dr Balmis, Alicante, SpainHospital Universitario de Bellvitge, Spain; Hospital Universitario de Donostia, Spain; Hospital Universitario Marqués de Valdecilla, Spain; Clínica Universidad de Navarra, Spain; Hospital Universitario Virgen del Rocio, Spain; Hospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), Spain; Hospital Insular de Gran Canaria, Spain; Hospital Universitario Rio Ortega, Spain; Hospital Universitario GermanTrias i Pujol, Spain; Hospital Universitario Doce de Octubre, Spain; Hospital Mutua de Terrassa, Spain; Hospital de la Santa Creu i Sant Pau, Spain; Hospital Universitario de Badajoz, Spain; Hospital Universitario Doctor Peset, Spain; Hospital Universitario de Basurto, Spain; Department of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; HospitalUniversitario Virgen de las Nieves, Spain; Complejo Hospitalario Universitario de Vigo, Spain; Hospital General Universitario de Albacete, Spain; Hospital Universitario Virgen de la Victoria, Spain; Hospital Universitario De A Coruña, Spain; Hospital Universitario Nuestra Sra. de la Candelaria, Spain; Hospital Universitario Josep Trueta, Spain; Hospital Universitario Príncipe de Asturias, Spain; Hospital Universitario Central de Asturias, Spain; Hospital del Mar, Spain; Hospital Universitario de Getafe, Spain; Hospital Universitario Arnau de Vilanova, Spain; Hospital Universitario Infanta Leonor, Spain; Hospital Universitario Morales Meseguer, Spain; Clínica La Luz, Spain; Hospital Universitario Miguel Servet, Zaragoza, Spain; Hospital Universitario, Hospital General Universitario Dr Balmis, Alicante, SpainHospital Universitario de Bellvitge, Spain; Hospital Universitario de Donostia, Spain; Hospital Universitario Marqués de Valdecilla, Spain; Clínica Universidad de Navarra, Spain; Hospital Universitario Virgen del Rocio, Spain; Hospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), Spain; Hospital Insular de Gran Canaria, Spain; Hospital Universitario Rio Ortega, Spain; Hospital Universitario GermanTrias i Pujol, Spain; Hospital Universitario Doce de Octubre, Spain; Hospital Mutua de Terrassa, Spain; Hospital de la Santa Creu i Sant Pau, Spain; Hospital Universitario de Badajoz, Spain; Hospital Universitario Doctor Peset, Spain; Hospital Universitario de Basurto, Spain; Department of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; HospitalUniversitario Virgen de las Nieves, Spain; Complejo Hospitalario Universitario de Vigo, Spain; Hospital General Universitario de Albacete, Spain; Hospital Universitario Virgen de la Victoria, Spain; Hospital Universitario De A Coruña, Spain; Hospital Universitario Nuestra Sra. de la Candelaria, Spain; Hospital Universitario Josep Trueta, Spain; Hospital Universitario Príncipe de Asturias, Spain; Hospital Universitario Central de Asturias, Spain; Hospital del Mar, Spain; Hospital Universitario de Getafe, Spain; Hospital Universitario Arnau de Vilanova, Spain; Hospital Universitario Infanta Leonor, Spain; Hospital Universitario Morales Meseguer, Spain; Clínica La Luz, Spain; Hospital Universitario Miguel Servet, Zaragoza, Spain; Hospital Universitario, Hospital General Universitario Dr Balmis, Alicante, SpainHospital Universitario de Bellvitge, Spain; Hospital Universitario de Donostia, Spain; Hospital Universitario Marqués de Valdecilla, Spain; Clínica Universidad de Navarra, Spain; Hospital Universitario Virgen del Rocio, Spain; Hospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), Spain; Hospital Insular de Gran Canaria, Spain; Hospital Universitario Rio Ortega, Spain; Hospital Universitario GermanTrias i Pujol, Spain; Hospital Universitario Doce de Octubre, Spain; Hospital Mutua de Terrassa, Spain; Hospital de la Santa Creu i Sant Pau, Spain; Hospital Universitario de Badajoz, Spain; Hospital Universitario Doctor Peset, Spain; Hospital Universitario de Basurto, Spain; Department of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; HospitalUniversitario Virgen de las Nieves, Spain; Complejo Hospitalario Universitario de Vigo, Spain; Hospital General Universitario de Albacete, Spain; Hospital Universitario Virgen de la Victoria, Spain; Hospital Universitario De A Coruña, Spain; Hospital Universitario Nuestra Sra. de la Candelaria, Spain; Hospital Universitario Josep Trueta, Spain; Hospital Universitario Príncipe de Asturias, Spain; Hospital Universitario Central de Asturias, Spain; Hospital del Mar, Spain; Hospital Universitario de Getafe, Spain; Hospital Universitario Arnau de Vilanova, Spain; Hospital Universitario Infanta Leonor, Spain; Hospital Universitario Morales Meseguer, Spain; Clínica La Luz, Spain; Hospital Universitario Miguel Servet, Zaragoza, Spain; Hospital Universitario, Hospital General Universitario Dr Balmis, Alicante, SpainHospital Universitario de Bellvitge, Spain; Hospital Universitario de Donostia, Spain; Hospital Universitario Marqués de Valdecilla, Spain; Clínica Universidad de Navarra, Spain; Hospital Universitario Virgen del Rocio, Spain; Hospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), Spain; Hospital Insular de Gran Canaria, Spain; Hospital Universitario Rio Ortega, Spain; Hospital Universitario GermanTrias i Pujol, Spain; Hospital Universitario Doce de Octubre, Spain; Hospital Mutua de Terrassa, Spain; Hospital de la Santa Creu i Sant Pau, Spain; Hospital Universitario de Badajoz, Spain; Hospital Universitario Doctor Peset, Spain; Hospital Universitario de Basurto, Spain; Department of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; HospitalUniversitario Virgen de las Nieves, Spain; Complejo Hospitalario Universitario de Vigo, Spain; Hospital General Universitario de Albacete, Spain; Hospital Universitario Virgen de la Victoria, Spain; Hospital Universitario De A Coruña, Spain; Hospital Universitario Nuestra Sra. de la Candelaria, Spain; Hospital Universitario Josep Trueta, Spain; Hospital Universitario Príncipe de Asturias, Spain; Hospital Universitario Central de Asturias, Spain; Hospital del Mar, Spain; Hospital Universitario de Getafe, Spain; Hospital Universitario Arnau de Vilanova, Spain; Hospital Universitario Infanta Leonor, Spain; Hospital Universitario Morales Meseguer, Spain; Clínica La Luz, Spain; Hospital Universitario Miguel Servet, Zaragoza, Spain; Hospital Universitario, Hospital General Universitario Dr Balmis, Alicante, SpainHospital Universitario de Bellvitge, Spain; Hospital Universitario de Donostia, Spain; Hospital Universitario Marqués de Valdecilla, Spain; Clínica Universidad de Navarra, Spain; Hospital Universitario Virgen del Rocio, Spain; Hospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), Spain; Hospital Insular de Gran Canaria, Spain; Hospital Universitario Rio Ortega, Spain; Hospital Universitario GermanTrias i Pujol, Spain; Hospital Universitario Doce de Octubre, Spain; Hospital Mutua de Terrassa, Spain; Hospital de la Santa Creu i Sant Pau, Spain; Hospital Universitario de Badajoz, Spain; Hospital Universitario Doctor Peset, Spain; Hospital Universitario de Basurto, Spain; Department of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; HospitalUniversitario Virgen de las Nieves, Spain; Complejo Hospitalario Universitario de Vigo, Spain; Hospital General Universitario de Albacete, Spain; Hospital Universitario Virgen de la Victoria, Spain; Hospital Universitario De A Coruña, Spain; Hospital Universitario Nuestra Sra. de la Candelaria, Spain; Hospital Universitario Josep Trueta, Spain; Hospital Universitario Príncipe de Asturias, Spain; Hospital Universitario Central de Asturias, Spain; Hospital del Mar, Spain; Hospital Universitario de Getafe, Spain; Hospital Universitario Arnau de Vilanova, Spain; Hospital Universitario Infanta Leonor, Spain; Hospital Universitario Morales Meseguer, Spain; Clínica La Luz, Spain; Hospital Universitario Miguel Servet, Zaragoza, Spain; Hospital Universitario, Hospital General Universitario Dr Balmis, Alicante, SpainHospital Universitario de Bellvitge, Spain; Hospital Universitario de Donostia, Spain; Hospital Universitario Marqués de Valdecilla, Spain; Clínica Universidad de Navarra, Spain; Hospital Universitario Virgen del Rocio, Spain; Hospital Clínico, University of Valencia, Biomedical Research Institute (INCLIVA), Spain; Hospital Insular de Gran Canaria, Spain; Hospital Universitario Rio Ortega, Spain; Hospital Universitario GermanTrias i Pujol, Spain; Hospital Universitario Doce de Octubre, Spain; Hospital Mutua de Terrassa, Spain; Hospital de la Santa Creu i Sant Pau, Spain; Hospital Universitario de Badajoz, Spain; Hospital Universitario Doctor Peset, Spain; Hospital Universitario de Basurto, Spain; Department of HPB Surgeryand Transplantation Unit, Division of General Surgery, Hospital La Fe and Hepatology, HBP Surgery and Transplants, IIS La Fe, Valencia, Spain; CIBERehd, Instituto de Salud Carlos III, Madrid, Spain; HospitalUniversitario Virgen de las Nieves, Spain; Complejo Hospitalario Universitario de Vigo, Spain; Hospital General Universitario de Albacete, Spain; Hospital Universitario Virgen de la Victoria, Spain; Hospital Universitario De A Coruña, Spain; Hospital Universitario Nuestra Sra. de la Candelaria, Spain; Hospital Universitario Josep Trueta, Spain; Hospital Universitario Príncipe de Asturias, Spain; Hospital Universitario Central de Asturias, Spain; Hospital del Mar, Spain; Hospital Universitario de Getafe, Spain; Hospital Universitario Arnau de Vilanova, Spain; Hospital Universitario Infanta Leonor, Spain; Hospital Universitario Morales Meseguer, Spain; Clínica La Luz, Spain; Hospital Universitario Miguel Servet, Zaragoza, Spain; Hospital Universitario, Hospital General Universitario Dr Balmis, Alicante, SpainHospital Universitario Miguel Servet, Zaragoza, SpainHospital Universitario, Hospital General Universitario Dr Balmis, Alicante, SpainIntroduction: The morbidity associated with left pancreatectomy (LP) is estimated at 20–25 % for major complications, with a mortality rate of 1–3 %. Diagnosing incidental pancreatic lesions, combined with an aging population and increased comorbidities, presents complex therapeutic challenges. This uncertainty raises the question of whether LP presents different morbidity and mortality profiles depending on the neoplasm type, potentially aiding decision-making. Objective: To compare postoperative outcomes by tumor type in a prospective series of LPs in Spain. Methods: The SPANDISPAN Project is a prospective, multicenter, observational study conducted in hepato-pancreato-biliary units from February 2022 to January 2023. A total of 311 patients from 41 Spanish centers participated. Patients were categorized by etiology: Adenocarcinoma (ADC), Intraductal Papillary Mucinous + Mucinous Cystic Neoplasms (IPMN + MCN), Neuroendocrine Tumors (NET), and Others. Pancreatic surgery-specific complications were defined by the International Study Group on Pancreatic Surgery (ISGPS). Results: Postoperative complications were similar overall and for Clavien-Dindo grade > II. No significant differences were observed in POPF, except that grade B/C was more frequent in NET (29.6 %, p < 0.039), mainly due to grade B (53.3 %). No differences were found in PPH or DGE, though the severity of hemorrhage differed significantly (p < 0.035), with grade B more common in Others and grade C in NET (66.7 %). Conclusion: No significant differences in complication rates were found based on etiology. Non-functioning NETs in elderly patients should be carefully assessed due to the increased severity of POPF, PPH, and reoperation rates.http://www.sciencedirect.com/science/article/pii/S1015958425011480Left pancreatectomyAdenocarcinomaNeuroendocrine tumorCystic lesionsPostoperative complication |
| spellingShingle | Belinda Sanchez-Pérez Candido F. Alcazar-Lopez Mario Serradilla-Martin Celia Villodres-Tudela Belen Hernández Julio Santoyo Santoyo Jose Manuel Ramia Juli Busquets Luis Secanella Nuria Peláez Maialen Alkorta Itziar De Ariño Hervas Mar Achalandabaso Boira Enrique Toledo Fernando Rotellar Pablo Martí-Cruchaga Miguel Ángel Gómez-Bravo Gonzalo Suárez Marina Garcés-Albir Luis Sabater Gabriel García Francisco Javier Alcalá Enrique Asensio David Pacheco Esteban Cugat Francisco Espín María Galófre Jorge Calvo Carmelo Loinaz M.I. García-Domingo Santiago Sánchez-Cabús Belén Martín Gerardo Blanco-Fernández Isabel Jaen-Torrejimeno Carlos Domingo del Pozo Carmen Payá Carmen González Sandra Ruiz Rafael López-Andújar Cristina Ballester Ana Belén Vico Natalia Zambudio Sergio Estévez Manuel Nogueira-Sixto José Ignacio Miota Belén Conde Miguel Ángel Suárez Jorge Roldán de la Rua Angelica Blanco Manuel González Pilar Elena González Betsabé Reyes Santiago López Ben Berta Tió Javier Mínguez García Inmaculada Lasa Unzúe Alberto Miyar Lorena Solar Fernando Burdio Benedetto Ielpo Alberto Carabias María Paloma Alfredo Escartín Fulthon Vela Elia Marqués Adelino Pérez Gloria Palomares Antonio Calvo José Tomás Castell María Jesús Castro M. Carmen Manzanares Enrique Artiguez Juan Luis Blas Luis Diez Alicia Calero Luis Muñoz Mario Rodríguez Daniel Aparicio-Lopez Juan J. Rubio-Garcia Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN) Asian Journal of Surgery Left pancreatectomy Adenocarcinoma Neuroendocrine tumor Cystic lesions Postoperative complication |
| title | Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN) |
| title_full | Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN) |
| title_fullStr | Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN) |
| title_full_unstemmed | Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN) |
| title_short | Does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy? A multicenter prospective snapshot study from the Spanish distal pancreatectomy project (SPANDISPAN) |
| title_sort | does the type of neoplasm influence the development of postoperative complications following distal pancreatectomy a multicenter prospective snapshot study from the spanish distal pancreatectomy project spandispan |
| topic | Left pancreatectomy Adenocarcinoma Neuroendocrine tumor Cystic lesions Postoperative complication |
| url | http://www.sciencedirect.com/science/article/pii/S1015958425011480 |
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