Research progress of left-right asymmetry development in vertebrates
In vertebrates, it is a remarkable feature that the internal organs and nervous system are asymmetrically distributed along the left-right axis. As same as the anterior-posterior and dorsal-ventral axes, left-right asymmetry is established progressively during the early developmental stage. Left-rig...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhejiang University Press
2020-12-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
| Subjects: | |
| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2020.03.040 |
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| Summary: | In vertebrates, it is a remarkable feature that the internal organs and nervous system are asymmetrically distributed along the left-right axis. As same as the anterior-posterior and dorsal-ventral axes, left-right asymmetry is established progressively during the early developmental stage. Left-right asymmetry development is induced by the conserved Nodal-Pitx2 signal. The concrete process includes the breaking of the symmetry, the establishment and maintenance of asymmetric signal, and the position of the eventual organ. The recent progress in left-right asymmetry development was reviewed. And recent researches have explored the establishment of left-right axis using model organisms such as mouse, zebrafish, Xenopus, etc., which help us deeply understand this developmental process. |
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| ISSN: | 1008-9209 2097-5155 |