Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS
Carbamazepine is the drug of first choice in the treatment of trigeminal neuralgia, epilepsy and other neurological diseases. Carbamazepine is known to have a narrow therapeutic range, and hereby the auto-induction of its metabolism with prolonged use cause the reduction of its therapeutic efficacy....
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| Format: | Article |
| Language: | Russian |
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Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)
2018-02-01
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| Series: | Регуляторные исследования и экспертиза лекарственных средств |
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| Online Access: | https://www.vedomostincesmp.ru/jour/article/view/60 |
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| author | T. A. Rodina E. S. Melnikov A. V. Sokolov A. B. Prokofiev V. V. Arkhipov G. V. Adamov D. L. Pozdnyakov Yu. V. Olefir |
| author_facet | T. A. Rodina E. S. Melnikov A. V. Sokolov A. B. Prokofiev V. V. Arkhipov G. V. Adamov D. L. Pozdnyakov Yu. V. Olefir |
| author_sort | T. A. Rodina |
| collection | DOAJ |
| description | Carbamazepine is the drug of first choice in the treatment of trigeminal neuralgia, epilepsy and other neurological diseases. Carbamazepine is known to have a narrow therapeutic range, and hereby the auto-induction of its metabolism with prolonged use cause the reduction of its therapeutic efficacy. Phenotyping of patients by the rate of carbamazepine metabolism allows to perform individual drug dose adjustment and to avoid the occurrence of adverse drug effects. In order to implement the mentioned approach, the method for simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide in human serum using HPLC-MS/MS was developed. |
| format | Article |
| id | doaj-art-a57a4b82be3345a3855edb58e05b5cd0 |
| institution | Matheson Library |
| issn | 3034-3062 3034-3453 |
| language | Russian |
| publishDate | 2018-02-01 |
| publisher | Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) |
| record_format | Article |
| series | Регуляторные исследования и экспертиза лекарственных средств |
| spelling | doaj-art-a57a4b82be3345a3855edb58e05b5cd02025-08-03T19:56:42ZrusFederal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)Регуляторные исследования и экспертиза лекарственных средств3034-30623034-34532018-02-0104202558Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MST. A. Rodina0E. S. Melnikov1A. V. Sokolov2A. B. Prokofiev3V. V. Arkhipov4G. V. Adamov5D. L. Pozdnyakov6Yu. V. Olefir7Federal State Budgetary Institution «Scientific Center for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation, The Moscow Department of Health I.V. Davydovsky City Clinical HospitalI.M. Sechenov First Moscow State Medical University, The Moscow Department of Health I.V. Davydovsky City Clinical HospitalFederal State Budgetary Institution «Scientific Center for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation, I.M. Sechenov First Moscow State Medical UniversityFederal State Budgetary Institution «Scientific Center for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation, I.M. Sechenov First Moscow State Medical University,The Moscow Department of Health I.V. Davydovsky City Clinical HospitalFederal State Budgetary Institution «Scientific Center for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation, I.M. Sechenov First Moscow State Medical University,The Moscow Department of Health I.V. Davydovsky City Clinical HospitalM. Sechenov First Moscow State Medical UniversityThe Moscow Department of Health I.V. Davydovsky City Clinical HospitalFederal State Budgetary Institution «Scientific Center for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationCarbamazepine is the drug of first choice in the treatment of trigeminal neuralgia, epilepsy and other neurological diseases. Carbamazepine is known to have a narrow therapeutic range, and hereby the auto-induction of its metabolism with prolonged use cause the reduction of its therapeutic efficacy. Phenotyping of patients by the rate of carbamazepine metabolism allows to perform individual drug dose adjustment and to avoid the occurrence of adverse drug effects. In order to implement the mentioned approach, the method for simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide in human serum using HPLC-MS/MS was developed.https://www.vedomostincesmp.ru/jour/article/view/60carbamazepinecarbamazepine-10,11-epoxydetherapeutic drug monitoringtrigeminal neuralgiahplc-ms/msкарбамазепинкарбамазепин-10,11-эпоксидтерапевтический лекарственный мониторингневралгия тройничного нервавэжх-мс/мс |
| spellingShingle | T. A. Rodina E. S. Melnikov A. V. Sokolov A. B. Prokofiev V. V. Arkhipov G. V. Adamov D. L. Pozdnyakov Yu. V. Olefir Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS Регуляторные исследования и экспертиза лекарственных средств carbamazepine carbamazepine-10,11-epoxyde therapeutic drug monitoring trigeminal neuralgia hplc-ms/ms карбамазепин карбамазепин-10,11-эпоксид терапевтический лекарственный мониторинг невралгия тройничного нерва вэжх-мс/мс |
| title | Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS |
| title_full | Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS |
| title_fullStr | Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS |
| title_full_unstemmed | Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS |
| title_short | Method of simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide by HPLC-MS/MS |
| title_sort | method of simultaneous determination of carbamazepine and carbamazepine 10 11 epoxide by hplc ms ms |
| topic | carbamazepine carbamazepine-10,11-epoxyde therapeutic drug monitoring trigeminal neuralgia hplc-ms/ms карбамазепин карбамазепин-10,11-эпоксид терапевтический лекарственный мониторинг невралгия тройничного нерва вэжх-мс/мс |
| url | https://www.vedomostincesmp.ru/jour/article/view/60 |
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